Skip to main content
Top
Published in: Obesity Surgery 9/2017

01-09-2017 | Original Contributions

Gallstone Disease After Laparoscopic Sleeve Gastrectomy in an Asian Population—What Proportion of Gallstones Actually Becomes Symptomatic?

Authors: Muhammed Yaser Hasan, Davide Lomanto, Lee Leng Loh, Jimmy Bok Yan So, Asim Shabbir

Published in: Obesity Surgery | Issue 9/2017

Login to get access

Abstract

Background

Despite evidence on gallstone disease after laparoscopic sleeve gastrectomy (LSG), there is an existing lack of consensus on practice guidelines, i.e., surveillance and stone-lowering prophylaxis. Available evidence also has a racial bias as western reports predominate current data. Considering the growing popularity of LSG in Asia and the unique Asian anthropometrics, we have attempted to provide a regional perspective by reviewing our LSG database to investigate the epidemiology of this complication.

Methods

One hundred two morbidly obese cases were retrospectively reviewed. Abdominal ultrasounds were conducted preoperatively and at 12-month post-op. No gallstone-lowering prophylaxis was used. Outcome measure was the incidence of new gallstone formation at 1 year and the rate of symptomatic stones during the follow-up period.

Results

Mean age was 43 years (range 20–68) with average initial BMI of 41.68 kg/m2. Preoperative gallstones were present in 14 (13.7%) cases. At 12-month post-op, 24 (27.5%) patients with no previous gallstone disease developed new stones. Within the mean follow-up period of 28.4 months, only one case (0.9%) developed gallstone complication requiring a cholecystectomy. We found no statistical difference in demographics, BMI variables (initial BMI, ΔBMI at 6 months and 1 year), and comorbidities between patients with new gallstone and those without stones.

Conclusion

Our results match western data in that gallstone formation is common after LSG though incidence of complicated stones is small. This is despite not using gallstone-lowering prophylaxis. The low conversion rate also questions the relevance of surveillance screening, as most patients with new gallstones remain asymptomatic at least in the short-term follow-up.
Literature
1.
go back to reference Zachariah SK et al. Laparoscopic sleeve gastrectomy for morbid obesity: 5 years experience from an Asian center of excellence. Obes Surg. 2013;23(7):939–46.CrossRefPubMed Zachariah SK et al. Laparoscopic sleeve gastrectomy for morbid obesity: 5 years experience from an Asian center of excellence. Obes Surg. 2013;23(7):939–46.CrossRefPubMed
2.
go back to reference Pok EH et al. Laparoscopic sleeve gastrectomy in Asia: long term outcome and revisional surgery. Asian J Surg. 2016;39(1):21–8.CrossRefPubMed Pok EH et al. Laparoscopic sleeve gastrectomy in Asia: long term outcome and revisional surgery. Asian J Surg. 2016;39(1):21–8.CrossRefPubMed
3.
4.
go back to reference Sioka E, Zacharoulis D, Zachari E, et al, Complicated gallstones after laparoscopic sleeve gastrectomy. J Obes, 2014. 468203 Sioka E, Zacharoulis D, Zachari E, et al, Complicated gallstones after laparoscopic sleeve gastrectomy. J Obes, 2014. 468203
5.
go back to reference Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin N Am. 1991;20(1):1–19. Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin N Am. 1991;20(1):1–19.
6.
go back to reference Shiffman ML et al. Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol. 1991;86(8):1000–5.PubMed Shiffman ML et al. Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol. 1991;86(8):1000–5.PubMed
7.
go back to reference Shiffman ML et al. Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. Gastroenterology. 1993;105(4):1200–8.CrossRefPubMed Shiffman ML et al. Gallbladder mucin, arachidonic acid, and bile lipids in patients who develop gallstones during weight reduction. Gastroenterology. 1993;105(4):1200–8.CrossRefPubMed
8.
go back to reference Shiffman ML et al. Gallstones in patients with morbid obesity. Relationship to body weight, weight loss and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord. 1993;17(3):153–8.PubMed Shiffman ML et al. Gallstones in patients with morbid obesity. Relationship to body weight, weight loss and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord. 1993;17(3):153–8.PubMed
9.
go back to reference Al-Jiffry BO et al. Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity. Can J Gastroenterol. 2003;17(3):169–74.CrossRefPubMed Al-Jiffry BO et al. Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity. Can J Gastroenterol. 2003;17(3):169–74.CrossRefPubMed
10.
go back to reference Deurenberg-Yap M et al. Relationships between indices of obesity and its co-morbidities in multi-ethnic Singapore. Int J Obes Relat Metab Disord. 2001;25(10):1554–62.CrossRefPubMed Deurenberg-Yap M et al. Relationships between indices of obesity and its co-morbidities in multi-ethnic Singapore. Int J Obes Relat Metab Disord. 2001;25(10):1554–62.CrossRefPubMed
11.
go back to reference Consultation, W.H.O.E. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63.CrossRef Consultation, W.H.O.E. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63.CrossRef
12.
go back to reference Li VK et al. Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk factors comparing gastric bypass, gastric banding, and sleeve gastrectomy. Surg Endosc. 2009;23(7):1640–4.CrossRefPubMed Li VK et al. Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk factors comparing gastric bypass, gastric banding, and sleeve gastrectomy. Surg Endosc. 2009;23(7):1640–4.CrossRefPubMed
13.
go back to reference Dhabuwala A, Cannan RJ, Stubbs RS. Improvement in co-morbidities following weight loss from gastric bypass surgery. Obes Surg. 2000;10(5):428–35.CrossRefPubMed Dhabuwala A, Cannan RJ, Stubbs RS. Improvement in co-morbidities following weight loss from gastric bypass surgery. Obes Surg. 2000;10(5):428–35.CrossRefPubMed
14.
go back to reference Iglezias Brandao de Oliveira C, Adami Chaim E, da Silva BB. Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg. 2003;13(4):625–8.CrossRefPubMed Iglezias Brandao de Oliveira C, Adami Chaim E, da Silva BB. Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg. 2003;13(4):625–8.CrossRefPubMed
15.
go back to reference Villegas L et al. Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg. 2004;14(2):206–11.CrossRefPubMed Villegas L et al. Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg. 2004;14(2):206–11.CrossRefPubMed
16.
go back to reference Kiewiet RM et al. Gallstone formation after weight loss following gastric banding in morbidly obese Dutch patients. Obes Surg. 2006;16(5):592–6.CrossRefPubMed Kiewiet RM et al. Gallstone formation after weight loss following gastric banding in morbidly obese Dutch patients. Obes Surg. 2006;16(5):592–6.CrossRefPubMed
17.
go back to reference O’Brien PE, Dixon JB. A rational approach to cholelithiasis in bariatric surgery: its application to the laparoscopically placed adjustable gastric band. Arch Surg. 2003;138(8):908–12.CrossRefPubMed O’Brien PE, Dixon JB. A rational approach to cholelithiasis in bariatric surgery: its application to the laparoscopically placed adjustable gastric band. Arch Surg. 2003;138(8):908–12.CrossRefPubMed
18.
go back to reference Adams LB et al. Randomized, prospective comparison of ursodeoxycholic acid for the prevention of gallstones after sleeve gastrectomy. Obes Surg. 2016;26(5):990–4.CrossRefPubMed Adams LB et al. Randomized, prospective comparison of ursodeoxycholic acid for the prevention of gallstones after sleeve gastrectomy. Obes Surg. 2016;26(5):990–4.CrossRefPubMed
19.
go back to reference Tsirline VB et al. How frequently and when do patients undergo cholecystectomy after bariatric surgery? Surg Obes Relat Dis. 2014;10(2):313–21.CrossRefPubMed Tsirline VB et al. How frequently and when do patients undergo cholecystectomy after bariatric surgery? Surg Obes Relat Dis. 2014;10(2):313–21.CrossRefPubMed
20.
go back to reference Hamad GG et al. Elective cholecystectomy during laparoscopic Roux-en-Y gastric bypass: is it worth the wait? Obes Surg. 2003;13(1):76–81.CrossRefPubMed Hamad GG et al. Elective cholecystectomy during laparoscopic Roux-en-Y gastric bypass: is it worth the wait? Obes Surg. 2003;13(1):76–81.CrossRefPubMed
21.
go back to reference Worni M et al. Cholecystectomy concomitant with laparoscopic gastric bypass: a trend analysis of the nationwide inpatient sample from 2001 to 2008. Obes Surg. 2012;22(2):220–9.CrossRefPubMed Worni M et al. Cholecystectomy concomitant with laparoscopic gastric bypass: a trend analysis of the nationwide inpatient sample from 2001 to 2008. Obes Surg. 2012;22(2):220–9.CrossRefPubMed
22.
go back to reference Uy MC et al. Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg. 2008;18(12):1532–8.CrossRefPubMed Uy MC et al. Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis. Obes Surg. 2008;18(12):1532–8.CrossRefPubMed
23.
go back to reference Benarroch-Gampel J et al. Cost-effectiveness analysis of cholecystectomy during Roux-en-Y gastric bypass for morbid obesity. Surgery. 2012;152(3):363–75.CrossRefPubMedPubMedCentral Benarroch-Gampel J et al. Cost-effectiveness analysis of cholecystectomy during Roux-en-Y gastric bypass for morbid obesity. Surgery. 2012;152(3):363–75.CrossRefPubMedPubMedCentral
Metadata
Title
Gallstone Disease After Laparoscopic Sleeve Gastrectomy in an Asian Population—What Proportion of Gallstones Actually Becomes Symptomatic?
Authors
Muhammed Yaser Hasan
Davide Lomanto
Lee Leng Loh
Jimmy Bok Yan So
Asim Shabbir
Publication date
01-09-2017
Publisher
Springer US
Published in
Obesity Surgery / Issue 9/2017
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-017-2657-y

Other articles of this Issue 9/2017

Obesity Surgery 9/2017 Go to the issue