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Published in: Surgical Endoscopy 11/2009

01-11-2009

Symptomatic gallstones after sleeve gastrectomy

Authors: Vicky Ka Ming Li, Nestor Pulido, Pedro Martinez-Suartez, Patricio Fajnwaks, Hei Ying Jin, Samuel Szomstein, Raul J. Rosenthal

Published in: Surgical Endoscopy | Issue 11/2009

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Abstract

Background

Cholelithiasis is a common complication after bariatric surgery. Pure restrictive procedures such as sleeve gastrectomy and gastric banding theoretically should result in less gallstone formation because the food continues to follow the normal gastrointestinal transit, maintaining the enteric–endocrine reflex intact. To the authors’ knowledge, the literature has no studies that analyze the incidence of gallstone formation after sleeve gastrectomy. This study aimed to compare the rates of symptomatic gallstones between laparoscopic Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG).

Methods

A retrospective chart review of patients who underwent laparoscopic RYGBP and SG between 2004 and 2006 was performed. The patients with previous cholecystectomy, known gallstones with or without concomitant cholecystectomy, and previous weight-reduction operations were excluded from the analysis. The outcome measures were the numbers of patients who had experienced symptomatic and complicated gallstones. Using Cox regression analysis, comparisons was made between the patients with laparoscopic RYGBP (group A) and those with laparoscopic SG (group B).

Results

Groups A excluded 174 (26%) of 670 patients, and group B excluded 27 (34.2%) of 79 patients. The patients in group A had a significantly higher preoperative body mass index (BMI) than those in group B. Additionally, more group A than group B patients had a BMI exceeding 45 and more than a 25% loss of original weight. No significant difference in the development of symptomatic (8.7% vs. 3.8%; p = 0.296) or complicated (1.8% vs. 1.9%; p = 0.956) gallstones was noted between the two groups

Conclusions

There was no significant difference in symptomatic or complicated gallstone disease between the patients treated with laparoscopic SG and those treated with laparoscopic RYGBP. Routine prophylactic cholecystectomy should not be recommended for weight reduction during laparoscopic SG.
Literature
1.
go back to reference Villegas L, Schneider B, Provost D, Chang C, Scott D, Sims T, Hill L, Hynan L, Jones D (2004) Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg 14:206–211CrossRefPubMed Villegas L, Schneider B, Provost D, Chang C, Scott D, Sims T, Hill L, Hynan L, Jones D (2004) Is routine cholecystectomy required during laparoscopic gastric bypass? Obes Surg 14:206–211CrossRefPubMed
2.
go back to reference Brandao I, de Oliveira C, Adami Chaim E, da Silva BB (2003) Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg 13:625–628CrossRef Brandao I, de Oliveira C, Adami Chaim E, da Silva BB (2003) Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery. Obes Surg 13:625–628CrossRef
3.
go back to reference Shiffman ML, Sugerman HJ, Kellum JM, Brewer WH, Moore EW (1991) Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol 86:1000–1005PubMed Shiffman ML, Sugerman HJ, Kellum JM, Brewer WH, Moore EW (1991) Gallstone formation after rapid weight loss: a prospective study in patients undergoing gastric bypass surgery for treatment of morbid obesity. Am J Gastroenterol 86:1000–1005PubMed
4.
go back to reference Dhabuwala A, Cannan RJ, Stubbs RS (2000) Improvement in comorbidities following weight loss from gastric bypass surgery. Obes Surg 10:428–435CrossRefPubMed Dhabuwala A, Cannan RJ, Stubbs RS (2000) Improvement in comorbidities following weight loss from gastric bypass surgery. Obes Surg 10:428–435CrossRefPubMed
5.
go back to reference Portenier DD, Grant JP, Blackwood HS, Pryor A, McMahon RL, Demaria E (2007) Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass. Surg Obes Relat Dis 3:476–479CrossRefPubMed Portenier DD, Grant JP, Blackwood HS, Pryor A, McMahon RL, Demaria E (2007) Expectant management of the asymptomatic gallbladder at Roux-en-Y gastric bypass. Surg Obes Relat Dis 3:476–479CrossRefPubMed
6.
go back to reference Bennion LJ, Grundy SM (1992) Risk factors for the development of cholelithiasis in man (second of two parts). N Engl J Med 307:798–800 Bennion LJ, Grundy SM (1992) Risk factors for the development of cholelithiasis in man (second of two parts). N Engl J Med 307:798–800
7.
go back to reference Diehl AK (1991) Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am 20:1–19PubMed Diehl AK (1991) Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am 20:1–19PubMed
8.
go back to reference Jorgensen T (1989) Gallstones in a Danish population: relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitus. Gut 30:528–534CrossRefPubMed Jorgensen T (1989) Gallstones in a Danish population: relation to weight, physical activity, smoking, coffee consumption, and diabetes mellitus. Gut 30:528–534CrossRefPubMed
10.
go back to reference Heaton KW, Braddon FEM, Mountford RA, Hughes AO, Emmett PM (1991) Symptomatic and silent gallstones in the community. Gut 32:316–320CrossRefPubMed Heaton KW, Braddon FEM, Mountford RA, Hughes AO, Emmett PM (1991) Symptomatic and silent gallstones in the community. Gut 32:316–320CrossRefPubMed
11.
go back to reference Stampfer MJ, Maclure KM, Colditz GA, Manson JE, Willett WC (1992) Risk of symptomatic gallstones in women with severe obesity. Am J Clin Nutr 55:652–658PubMed Stampfer MJ, Maclure KM, Colditz GA, Manson JE, Willett WC (1992) Risk of symptomatic gallstones in women with severe obesity. Am J Clin Nutr 55:652–658PubMed
12.
go back to reference AI-Jiffry BO, Shaffer EA, Saccone GT, Downey P, Kow L, Toouli J (2003) Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity. Can J Gastroenterol 17:169–174 AI-Jiffry BO, Shaffer EA, Saccone GT, Downey P, Kow L, Toouli J (2003) Changes in gallbladder motility and gallstone formation following laparoscopic gastric banding for morbid obesity. Can J Gastroenterol 17:169–174
13.
go back to reference Kiewiet RM, Durian MF, van Leersum M, Hesp FLEM, van Vliet ACM (2006) Gallstone formation after weight loss following gastric banding in morbidly obese Dutch patients. Obes Surg 16:592–596CrossRefPubMed Kiewiet RM, Durian MF, van Leersum M, Hesp FLEM, van Vliet ACM (2006) Gallstone formation after weight loss following gastric banding in morbidly obese Dutch patients. Obes Surg 16:592–596CrossRefPubMed
14.
go back to reference O’Brien PE, Dixon JB (2003) A rational approach to cholelithiasis in bariatric surgery. Arch Surg 138:908–912CrossRefPubMed O’Brien PE, Dixon JB (2003) A rational approach to cholelithiasis in bariatric surgery. Arch Surg 138:908–912CrossRefPubMed
15.
go back to reference Rubino F, Gagner M, Gentileschi P, Kini S, Fukuyama S, Feng J, Diamond E (2004) The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg 240:236–242CrossRefPubMed Rubino F, Gagner M, Gentileschi P, Kini S, Fukuyama S, Feng J, Diamond E (2004) The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg 240:236–242CrossRefPubMed
16.
go back to reference Kellum JM, Kuemmerle JF, O’Dorisio TM, Rayford P, Martin D, Engle K, Wolf L, Sugerman HJ (1990) Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplasty. Ann Surg 211:763–771CrossRefPubMed Kellum JM, Kuemmerle JF, O’Dorisio TM, Rayford P, Martin D, Engle K, Wolf L, Sugerman HJ (1990) Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplasty. Ann Surg 211:763–771CrossRefPubMed
17.
18.
go back to reference Shiffman ML, Sugerman HJ, Kellum JH, Brewer WH, Moore EW (1993) Gallstones in patients with morbid obesity: relationship to body weight, weight loss, and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord 17:153–158PubMed Shiffman ML, Sugerman HJ, Kellum JH, Brewer WH, Moore EW (1993) Gallstones in patients with morbid obesity: relationship to body weight, weight loss, and gallbladder bile cholesterol solubility. Int J Obes Relat Metab Disord 17:153–158PubMed
19.
go back to reference Miller K, Hell E, Lang B, Lengauer E (2003) Gallstone formation prophylaxis after gastric restrictive procedured for weight loss: a randomized double-blind placebo-controlled trial. Ann Surg 238:697–702CrossRefPubMed Miller K, Hell E, Lang B, Lengauer E (2003) Gallstone formation prophylaxis after gastric restrictive procedured for weight loss: a randomized double-blind placebo-controlled trial. Ann Surg 238:697–702CrossRefPubMed
20.
go back to reference Scott DJ, Villegas L, Sims TL (2003) Intraoperative ultrasound and prophylactic ursodiol for gallstone prevention following laparoscopic gastric bypass. Surg Endosc 17:1796–1802CrossRefPubMed Scott DJ, Villegas L, Sims TL (2003) Intraoperative ultrasound and prophylactic ursodiol for gallstone prevention following laparoscopic gastric bypass. Surg Endosc 17:1796–1802CrossRefPubMed
21.
go back to reference Ammori BJ, Vezakis A, Davides D, Martin IG, Larvin M, McMahon MJ (2001) laparoscopic cholecystectomy in morbidly obese patients. Surg Endosc 15:1136–1139 Ammori BJ, Vezakis A, Davides D, Martin IG, Larvin M, McMahon MJ (2001) laparoscopic cholecystectomy in morbidly obese patients. Surg Endosc 15:1136–1139
22.
go back to reference Fobi M, Lee H, Igwe D, Felaphy B, James E, Stanczyk M, Fobi N (2002) Prophylatic cholecystectomy with gastric bypass operation: incidence of gallbladder disease. Obes Surg 12:350–353CrossRefPubMed Fobi M, Lee H, Igwe D, Felaphy B, James E, Stanczyk M, Fobi N (2002) Prophylatic cholecystectomy with gastric bypass operation: incidence of gallbladder disease. Obes Surg 12:350–353CrossRefPubMed
23.
go back to reference Fakhry SM, Herbst CA, Buckwalter JA (1987) Cholecystectomy in morbidly obese patients. Am Surg 53:26–28PubMed Fakhry SM, Herbst CA, Buckwalter JA (1987) Cholecystectomy in morbidly obese patients. Am Surg 53:26–28PubMed
24.
25.
go back to reference Erlinger S (2000) Gallstones in obesity and weight loss. Eur J Gastroenterol Hepatol 12:1347–1352CrossRefPubMed Erlinger S (2000) Gallstones in obesity and weight loss. Eur J Gastroenterol Hepatol 12:1347–1352CrossRefPubMed
26.
go back to reference Yang H, Peterson GM, Roth MP, Schoenfield LJ, Marks JW (1992) Risk factors for gallstones formation during rapid loss of weight. Dig Dis Sci 37:912–918CrossRefPubMed Yang H, Peterson GM, Roth MP, Schoenfield LJ, Marks JW (1992) Risk factors for gallstones formation during rapid loss of weight. Dig Dis Sci 37:912–918CrossRefPubMed
27.
go back to reference Samuel I, Mason EE, Renquist KE, Huang YH, Zimmerman MB, Jamal M (2006) Bariatric surgery trends: an 18-year report from the International Bariatric Surgery Registry. Am J Surg 192:657–662CrossRefPubMed Samuel I, Mason EE, Renquist KE, Huang YH, Zimmerman MB, Jamal M (2006) Bariatric surgery trends: an 18-year report from the International Bariatric Surgery Registry. Am J Surg 192:657–662CrossRefPubMed
28.
go back to reference Mark SS, John JC, Francis HS, Marleen MM, Barbara S, William T, Gary SD (1988) Ultrasound evaluation of cholelithiasis in the morbidly obese. Abdom Imaging 13:345–346 Mark SS, John JC, Francis HS, Marleen MM, Barbara S, William T, Gary SD (1988) Ultrasound evaluation of cholelithiasis in the morbidly obese. Abdom Imaging 13:345–346
29.
go back to reference Oria HE (1998) Pitfalls in the diagnosis of gallbladder disease in clinically severe obesity. Obes Surg 8:444–451CrossRefPubMed Oria HE (1998) Pitfalls in the diagnosis of gallbladder disease in clinically severe obesity. Obes Surg 8:444–451CrossRefPubMed
Metadata
Title
Symptomatic gallstones after sleeve gastrectomy
Authors
Vicky Ka Ming Li
Nestor Pulido
Pedro Martinez-Suartez
Patricio Fajnwaks
Hei Ying Jin
Samuel Szomstein
Raul J. Rosenthal
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
Surgical Endoscopy / Issue 11/2009
Print ISSN: 0930-2794
Electronic ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-009-0422-6

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