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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2020

01-12-2020 | Magnetic Resonance Imaging | Original Article

Correlation of bone mineral density with MRI T2* values in quantitative analysis of lumbar osteoporosis

Authors: Hui-Zhao Wu, Xiao-Fei Zhang, Shu-Man Han, Lei Cao, Jin-Xu Wen, Wen-Juan Wu, Bu-Lang Gao

Published in: Archives of Osteoporosis | Issue 1/2020

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Abstract

Summary

We found that the MRI T2* value is moderately negatively correlated with the bone mineral density assessed with quantitative computed tomography in evaluating osteoporosis in postmenopausal women and may have some potential in assessing severity of lumbar osteoporosis for scientific research.

Purpose

To investigate the T2* quantitative measurement in magnetic resonance imaging (MRI) and its correlation with the bone mineral density (BMD) values evaluated with quantitative computed tomography (QCT) in women with postmenopausal lumbar vertebrae osteoporosis.

Materials and methods

Eighty-seven postmenopausal women were enrolled who had MRI scanning with T1WI, T2WI, and T2* mapping sequences and QCT evaluation of BMD. The T2* value and the BMD were assessed in lumbar vertebral bodies 2–4. Based on the BMD values, the patients were divided into three groups: normal, osteopenia, and osteoporosis.

Results

The inter- and intra-observer intraclass correlation coefficients (ICCs) for T2* were 0.91 (0.87–0.94, 95% CI) and 0.93 (0.88–0.95, 95% CI), respectively. The inter- and intra-observer ICCs for the BMD value were 0.89 (0.83–0.92, 95% CI) and 0.91 (0.86–0.93, 95% CI), respectively. The differences of the T2* values and BMD among the three groups were statistically significant (P < 0.05). The BMD value was greater in the normal group (145.02 ± 18.94 mg/cm3) than the other two groups (97.90 ± 16.18 mg/cm3 for osteopenia and 59.09 ± 18.71 mg/cm3 for osteoporosis). The normal group had a significantly (P < 0.05) smaller T2* value than the other two groups (8.39 ± 4.17 ms in the normal group versus 12.25 ± 3.36 ms in the osteopenia or 15.54 ± 4.9 ms in the osteoporosis). A significant (P < 0.05) difference also existed in the T2* value between the osteopenia and the osteoporosis groups. The correlations of the T2* values with BMD values were significantly (P < 0.05) negative after adjusting for age (r = − 0.33, − 0.45, and − 0.51 for normal, osteopenia, and osteoporosis, respectively).

Conclusion

The MRI T2*value is moderately negatively correlated with the bone mineral density assessed with quantitative computed tomography in evaluating osteoporosis in postmenopausal women and may have some potential in assessing severity of lumbar osteoporosis for scientific research.
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Metadata
Title
Correlation of bone mineral density with MRI T2* values in quantitative analysis of lumbar osteoporosis
Authors
Hui-Zhao Wu
Xiao-Fei Zhang
Shu-Man Han
Lei Cao
Jin-Xu Wen
Wen-Juan Wu
Bu-Lang Gao
Publication date
01-12-2020
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2020
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-020-0682-2

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