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01-12-2020 | Osteoporosis | Review

A systematic review of the Irish osteoporotic vertebral fracture literature

Authors: Eva McCabe, Ammar Ibrahim, Rajneet Singh, Michael Kelly, Catherine Armstrong, Fiona Heaney, Diane Bergin, John P. McCabe, John J. Carey

Published in: Archives of Osteoporosis | Issue 1/2020

Abstract

Introduction

Vertebral fractures (VF) are the most common osteoporotic fracture. They are associated with significant morbidity and mortality and are an important predictor of future fractures. The epidemiology of VF in Ireland is limited and a greater understanding of their scale and impact is needed. Therefore, we conducted a systematic review of publications on osteoporotic VF in Ireland.

Methods

Systematic searches were conducted using PubMed, Medline, Embase, Scopus and Cochrane electronic databases to identify eligible publications from Ireland addressing osteoporotic VF.

Results

Twenty studies met the inclusion criteria out of 1558 citations. All studies were published since 2000. Data was obtained on 182,771 patients with fractures. Nine studies included more than 100 subjects and three included more than 1000. Females accounted for 70% with an overall mean age of 65.2 years (30–94). There was significant heterogeneity in study design, methods and outcome measures including the following: use of administrative claims data on public hospital admissions, surgical and medical interventions, the impact of a fracture liaison service and the osteoporosis economic burden. The prevalence of VF was difficult to ascertain due to definitions used and differences in the study populations. Only two studies systematically reviewed spine imaging using blinded assessors and validated diagnostic criteria to assess the prevalence of fractures in patient cohorts.

Conclusions

Several studies show that VF are common when addressed systematically and the prevalence may be rising. However, there is a deficit of large studies systematically addressing the epidemiology and their importance in Ireland.

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Title: A systematic review of the Irish osteoporotic vertebral fracture literature
Authors: Eva McCabe
Ammar Ibrahim
Rajneet Singh
Michael Kelly
Catherine Armstrong
Fiona Heaney
Diane Bergin
John P. McCabe
John J. Carey
Publication date: 01-12-2020
Publisher: Springer London
Keywords: Osteoporosis
Osteoporosis
Published in: Archives of Osteoporosis / Issue 1/2020
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-020-0704-0

At a glance: The STEP trials

Springer Medicine

A systematic review of the Irish osteoporotic vertebral fracture literature

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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