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Journal of General Internal Medicine
Published in: Journal of General Internal Medicine 1/2022

01-01-2022 | Myalgie | Concise Research Report

Impact of Metformin on Statin Persistence: a Post Hoc Analysis of a Large Randomized Controlled Trial

Authors: Byron Cheon, MS, Ambuj Kumar, MD, MPH, Athanasios Tsalatsanis, PhD, Kevin Cowart, PharmD, MPH, Ronald R. Magness, PhD, Srinivas M. Tipparaju, PhD, Nicholas W. Carris, PharmD

Published in: Journal of General Internal Medicine | Issue 1/2022

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Excerpt

Optimal cardiovascular disease (CVD) risk reduction is impaired by statin-associated muscle symptoms (SAMS).1‐3 Severe muscle reactions are well accounted for, yet mild-to-moderate myalgia is common and difficult to track. No valid SAMS therapies exist, and management requires trial-and-error with different statins until one is tolerated.1 …
Literature
1.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139:e1046-e1081.PubMed
2.
Zhang H, Plutzky J, Skentzos S, et al. Discontinuation of statins in routine care settings: a cohort study. Ann Intern Med 2013;158(7):526-34.CrossRef
3.
Carris NW, Tipparaju SM, Magness DJ, et al. Pleiotropic effects of metformin to rescue statin-induced muscle injury and insulin resistance: A proposed mechanism and potential clinical implications. Med Hypotheses 2017;107:39-44.CrossRef
4.
Carris NW, Tsalatsanis A, Tipparaju SM, et al. Metformin's impact on statin-associated muscle symptoms: An analysis of ACCORD study data and research materials from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center. Diabetes Obes Metab 2018;20:1994-9.CrossRef
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Ginsberg HN, Elam MB, Lovato LC, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010;362:1563-74.CrossRef
6.
Soric MM, Moorman JM, Boyle JA, Dengler-Crish CM. Prevalence and Predictors of Metformin Prescribing in Adults with Type 2 Diabetes Mellitus: A National Cross-Sectional Study. Pharmacotherapy. 2016;36:715-722.CrossRef
Metadata
Title
Impact of Metformin on Statin Persistence: a Post Hoc Analysis of a Large Randomized Controlled Trial
Authors
Byron Cheon, MS
Ambuj Kumar, MD, MPH
Athanasios Tsalatsanis, PhD
Kevin Cowart, PharmD, MPH
Ronald R. Magness, PhD
Srinivas M. Tipparaju, PhD
Nicholas W. Carris, PharmD
Publication date
01-01-2022
Publisher
Springer International Publishing
Published in
Journal of General Internal Medicine / Issue 1/2022
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-020-06344-6

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