Skip to main content
Top
Published in: Journal of General Internal Medicine 2/2020

01-02-2020 | Care

Doubling Hepatitis C Virus Screening in Primary Care Using Advanced Electronic Health Record Tools—A Non-Randomized Controlled Trial

Authors: Leila Hojat, MD, Ann Avery, MD, Peter J. Greco, MD, David C. Kaelber, MD, PhD, MPH

Published in: Journal of General Internal Medicine | Issue 2/2020

Login to get access

Abstract

Background

Hepatitis C virus (HCV) infection is a major public health burden, affecting over 4 million people. The Centers for Disease Control and Prevention and the US Preventive Services Task Force guidelines recommend screening everyone born between 1945 and 1965, but screening rates remain low.

Objective

To determine whether bulk ordering and electronic messaging to patients improves guideline-based HCV screening rates.

Design

A non-randomized controlled trial of 1024 adults from November 2016 to March 2017.

Participants

Patients due for HCV screening with at least one primary care office visit in one of three primary care clinics and enrolled in the healthcare system’s tethered personal health record (tPHR).

Interventions

Control patients received normal care for HCV screening, consisting of passive HCV reminders to providers during face-to-face visits and passive HCV screening notification through the patient’s tPHR. Intervention patients received normal care and also had HCV antibody tests ordered for them and customized messages sent through their tPHR inviting them to go directly to the lab for HCV screening over a 12-week period.

Main Measures

Percentage/number of patients receiving HCV antibody tests during the intervention period. Percentage/number of intervention group patients receiving HCV screening with other blood work.

Key Results

In the intervention group, 33% (168 of 514) completed HCV testing, compared with 19% (97 of 510) of controls (OR 1.7, 95% CI 1.2–2.1). Bulk lab ordering appeared to have a large impact while bulk messaging appeared to have a less significant role.

Conclusions

Leveraging population analytics and bulk ordering in an electronic health record with bulk messaging to a tPHR directly engages patients in blood screening tests and can significantly improve completion. This methodology has a broad range of applications including many recommended screening or disease-specific testing. This bulk ordering and direct-to-patient messaging approach improves patient screening while decreasing provider/staff work.

Trial Registration

MetroHealth IRB16-00776 (ClinicalTrials.​gov)
Literature
1.
go back to reference Hofmeister MG, Rosenthal EM, Barker LK, et al. Estimating prevalence of hepatitis C virus infection in the United States, 2013–2016. Hepatology 2019;69:1020–31.CrossRef Hofmeister MG, Rosenthal EM, Barker LK, et al. Estimating prevalence of hepatitis C virus infection in the United States, 2013–2016. Hepatology 2019;69:1020–31.CrossRef
2.
go back to reference Klevens RM, Hu DJ, Jiles R, Holmberg SD. Evolving epidemiology of hepatitis C virus in the United States. Clin Infect Dis 2012;55 Suppl 1:S3–9.CrossRef Klevens RM, Hu DJ, Jiles R, Holmberg SD. Evolving epidemiology of hepatitis C virus in the United States. Clin Infect Dis 2012;55 Suppl 1:S3–9.CrossRef
3.
go back to reference Ly KN, Xing J, Klevens RM, Jiles RB, Ward JW, Holmberg SD. The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. Ann Intern Med 2012;156:271–8.CrossRef Ly KN, Xing J, Klevens RM, Jiles RB, Ward JW, Holmberg SD. The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. Ann Intern Med 2012;156:271–8.CrossRef
4.
go back to reference Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965. MMWR Recomm Rep 2012;61:1–32.PubMed Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965. MMWR Recomm Rep 2012;61:1–32.PubMed
5.
go back to reference Moyer VA. Screening for hepatitis C virus infection in adults: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine 2013;159:349–57.CrossRef Moyer VA. Screening for hepatitis C virus infection in adults: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine 2013;159:349–57.CrossRef
6.
go back to reference Easterbrook P, Johnson C, Figueroa C, Baggaley R. HIV and hepatitis testing: global progress, challenges, and future directions. AIDS Rev 2016;18:3–14.PubMed Easterbrook P, Johnson C, Figueroa C, Baggaley R. HIV and hepatitis testing: global progress, challenges, and future directions. AIDS Rev 2016;18:3–14.PubMed
7.
go back to reference Sarkar S, Esserman DA, Skanderson M, Levin FL, Justice AC, Lim JK. Disparities in hepatitis C testing in U.S. veterans born 1945–1965. J Hepatol 2016;65:259–65.CrossRef Sarkar S, Esserman DA, Skanderson M, Levin FL, Justice AC, Lim JK. Disparities in hepatitis C testing in U.S. veterans born 1945–1965. J Hepatol 2016;65:259–65.CrossRef
8.
go back to reference Rayment M, Thornton A, Mandalia S, et al. HIV testing in non-traditional settings – the HINTS Study: a multi-centre observational study of feasibility and acceptability. PLoS ONE 2012;7:e39530.CrossRef Rayment M, Thornton A, Mandalia S, et al. HIV testing in non-traditional settings – the HINTS Study: a multi-centre observational study of feasibility and acceptability. PLoS ONE 2012;7:e39530.CrossRef
9.
go back to reference Rumble C, Pevalin DJ, O’Moore E. Routine testing for blood-borne viruses in prisons: a systematic review. Eur J Public Health 2015;25:1078–88.CrossRef Rumble C, Pevalin DJ, O’Moore E. Routine testing for blood-borne viruses in prisons: a systematic review. Eur J Public Health 2015;25:1078–88.CrossRef
10.
go back to reference O’Connell S, Lillis D, Cotter A, et al. Opt-out panel testing for HIV, hepatitis B and hepatitis C in an urban emergency department: a pilot study. PLoS One 2016;11:e0150546.CrossRef O’Connell S, Lillis D, Cotter A, et al. Opt-out panel testing for HIV, hepatitis B and hepatitis C in an urban emergency department: a pilot study. PLoS One 2016;11:e0150546.CrossRef
11.
go back to reference Turner BJ, Taylor BS, Hanson JT, et al. Implementing hospital-based baby boomer hepatitis C virus screening and linkage to care: strategies, results, and costs. J Hosp Med 2015;10:510–6.CrossRef Turner BJ, Taylor BS, Hanson JT, et al. Implementing hospital-based baby boomer hepatitis C virus screening and linkage to care: strategies, results, and costs. J Hosp Med 2015;10:510–6.CrossRef
12.
go back to reference Rayment M, Rae C, Ghooloo F, et al. Routine HIV testing in the emergency department: tough lessons in sustainability. HIV Med 2013;14 Suppl 3:6–9.CrossRef Rayment M, Rae C, Ghooloo F, et al. Routine HIV testing in the emergency department: tough lessons in sustainability. HIV Med 2013;14 Suppl 3:6–9.CrossRef
13.
go back to reference Roehrs A, da Costa CA, Righi RdR, de Oliveira KSF. Personal health records: a systematic literature review. J Med Internet Res 2017;19:e13.CrossRef Roehrs A, da Costa CA, Righi RdR, de Oliveira KSF. Personal health records: a systematic literature review. J Med Internet Res 2017;19:e13.CrossRef
14.
go back to reference Bar-Shain DS, Stager MM, Runkle AP, Leon JB, Kaelber DC. Direct messaging to parents/guardians to improve adolescent immunizations. J Adolesc Health 2015;56:S21–6.CrossRef Bar-Shain DS, Stager MM, Runkle AP, Leon JB, Kaelber DC. Direct messaging to parents/guardians to improve adolescent immunizations. J Adolesc Health 2015;56:S21–6.CrossRef
15.
go back to reference Shea S, DuMouchel W, Bahamonde L. A meta-analysis of 16 randomized controlled trials to evaluate computer-based clinical reminder systems for preventive care in the ambulatory setting. J Am Med Inform Assoc 1996;3:399–409.CrossRef Shea S, DuMouchel W, Bahamonde L. A meta-analysis of 16 randomized controlled trials to evaluate computer-based clinical reminder systems for preventive care in the ambulatory setting. J Am Med Inform Assoc 1996;3:399–409.CrossRef
16.
go back to reference Arditi C, Rege-Walther M, Wyatt JC, Durieux P, Burnand B. Computer-generated reminders delivered on paper to healthcare professionals; effects on professional practice and health care outcomes. Cochrane Database Syst Rev 2012;12:Cd001175.PubMed Arditi C, Rege-Walther M, Wyatt JC, Durieux P, Burnand B. Computer-generated reminders delivered on paper to healthcare professionals; effects on professional practice and health care outcomes. Cochrane Database Syst Rev 2012;12:Cd001175.PubMed
17.
go back to reference Aspinall EJ, Doyle JS, Corson S, et al. Targeted hepatitis C antibody testing interventions: a systematic review and meta-analysis. Eur J Epidemiol 2015;30:115–29.CrossRef Aspinall EJ, Doyle JS, Corson S, et al. Targeted hepatitis C antibody testing interventions: a systematic review and meta-analysis. Eur J Epidemiol 2015;30:115–29.CrossRef
18.
go back to reference Sidlow R, Msaouel P. Improving hepatitis C virus screening rates in primary care: a targeted intervention using the electronic health record. J Healthc Qual 2015;37:319–23.CrossRef Sidlow R, Msaouel P. Improving hepatitis C virus screening rates in primary care: a targeted intervention using the electronic health record. J Healthc Qual 2015;37:319–23.CrossRef
19.
go back to reference Burke RC, Sepkowitz KA, Bernstein KT, et al. Why don’t physicians test for HIV? A review of the US literature. Aids 2007;21:1617–24.CrossRef Burke RC, Sepkowitz KA, Bernstein KT, et al. Why don’t physicians test for HIV? A review of the US literature. Aids 2007;21:1617–24.CrossRef
20.
go back to reference El Khoury AC, Klimack WK, Wallace C, Razavi H. Economic burden of hepatitis C-associated diseases in the United States. J Viral Hepat 2012;19:153–60.CrossRef El Khoury AC, Klimack WK, Wallace C, Razavi H. Economic burden of hepatitis C-associated diseases in the United States. J Viral Hepat 2012;19:153–60.CrossRef
21.
go back to reference Panneer N, Lontok E, Branson BM, et al. HIV and hepatitis C virus infection in the United States: whom and how to test. Clin Infect Dis 2014;59:875–82.CrossRef Panneer N, Lontok E, Branson BM, et al. HIV and hepatitis C virus infection in the United States: whom and how to test. Clin Infect Dis 2014;59:875–82.CrossRef
Metadata
Title
Doubling Hepatitis C Virus Screening in Primary Care Using Advanced Electronic Health Record Tools—A Non-Randomized Controlled Trial
Authors
Leila Hojat, MD
Ann Avery, MD
Peter J. Greco, MD
David C. Kaelber, MD, PhD, MPH
Publication date
01-02-2020
Publisher
Springer US
Keywords
Care
Hepatitis C
Published in
Journal of General Internal Medicine / Issue 2/2020
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-019-05536-z

Other articles of this Issue 2/2020

Journal of General Internal Medicine 2/2020 Go to the issue