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Journal of General Internal Medicine
Published in: Journal of General Internal Medicine 1/2020

01-01-2020 | Concise Research Report

Extended-Release Formulation and Medication Adherence

Authors: John A. Romley, PhD, Zhiwen Xie, MA, Tommy Chiou, BA, Dana Goldman, PhD, Anne L. Peters, MD

Published in: Journal of General Internal Medicine | Issue 1/2020

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Excerpt

Suboptimal adherence to chronic medications undermines treatment effectiveness and costs the USA as much as $289 billion annually.1 Prescription of extended-release (XR) formulations may offer a partial solution, as past studies have found that XR formulations can improve adherence.2 However, the majority of past studies have analyzed adherence to XR formulations only in the context of specific medications and short-term time frames (< 1 year).3, 4 This study investigates the effects of XR on long-term (≥ 1 year) adherence across 15 chronic medications, as well as the influence of cost-sharing on XR usage. …
Literature
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Viswanathan M, Golin CE, Jones CD, et al. Interventions to improve adherence to self-administered medications for chronic diseases in the united states: a systematic review. Ann Intern Med. 2012;157(11):785–795.CrossRef
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Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med. 2008;31(3):213–224.CrossRef
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Wang L, Sun X, Du L, et al. Effects and patient compliance of sustained-release versus immediate-release glipizides in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. J Evid Based Med. 2011;4(4):232–241.CrossRef
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Adler LD, Nierenberg AA. Review of Medication Adherence in Children and Adults with ADHD. Postgrad Med. 2010;122(1):184–191.CrossRef
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Sperber CM, Samarasinghe SR, Lomax GP. An upper and lower bound of the medication possession ratio. Patient Prefer Adherence. 2017;11:1469CrossRef
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Choudhry NK, Avorn J, Glynn RJ, et al. Full coverage for preventive medications after myocardial infarction. N Engl J Med. 2011;365(22):2088–2097.CrossRef
Metadata
Title
Extended-Release Formulation and Medication Adherence
Authors
John A. Romley, PhD
Zhiwen Xie, MA
Tommy Chiou, BA
Dana Goldman, PhD
Anne L. Peters, MD
Publication date
01-01-2020
Publisher
Springer US
Published in
Journal of General Internal Medicine / Issue 1/2020
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-019-05275-1

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