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Published in: Journal of General Internal Medicine 2/2019

01-02-2019 | Original Research

Rising Mortality Rate of Cervical Cancer in Younger Women in Urban China

Authors: Min Wei, MD, Wei Zhou, MS, Yongyi Bi, PhD, Hong Wang, PhD, Yu Liu, PhD, Zhi-Jiang Zhang, PhD

Published in: Journal of General Internal Medicine | Issue 2/2019

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Abstract

Background

In recent decades, much effort has been made in China to reduce the burden of cervical cancer.

Objective

Our study’s purpose was to examine trends of cervical cancer mortality in each 5-year age group for urban and rural Chinese women, respectively.

Designs

Retrospective analysis of cervical cancer mortality from 1987 to 2015 from the World Health Organization Cancer Mortality Database and China Health Statistical Yearbooks.

Participants

Chinese women.

Main Measures

Trends were examined using annual percent change (APC) and average annual percent change (AAPC) via Joinpoint regression models for each 5-year age group in urban and rural areas, respectively.

Results

In urban China, mortality rate of cervical cancer increased significantly among urban women aged 25–54 years (AAPC 2.12~5.49%), in contrast to a decline trend among urban women older than 60 years (AAPC − 3.61~− 5.35%). In rural China, cervical cancer rates declined in all age groups, but the magnitude was smaller in women aged 30–54 years (AAPC − 0.59~− 2.20%) compared to women older than 55 years (AAPC − 3.06~− 4.33%).

Conclusion

Mortality rate of cervical cancer is rising at an alarming rate in younger women in urban China. Timely intervention is required for these vulnerable populations.
Appendix
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Literature
1.
go back to reference Torre LA, Islami F, Siegel RL, Ward EM, Jemal A. Global Cancer in Women: Burden and Trends. Cancer Epidemiol Biomark Prev 2017; 26: 444–457.CrossRef Torre LA, Islami F, Siegel RL, Ward EM, Jemal A. Global Cancer in Women: Burden and Trends. Cancer Epidemiol Biomark Prev 2017; 26: 444–457.CrossRef
2.
go back to reference Fidler MM, Gupta S, Soerjomataram I, Ferlay J, Steliarova-Foucher E, Bray F. Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study. Lancet Oncol 2017; 18(12): 1579–1589. Fidler MM, Gupta S, Soerjomataram I, Ferlay J, Steliarova-Foucher E, Bray F. Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study. Lancet Oncol 2017; 18(12): 1579–1589.
3.
go back to reference Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin 2016; 66: 115–132.CrossRefPubMed Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin 2016; 66: 115–132.CrossRefPubMed
4.
go back to reference Qiao YL, Sellors JW, Eder PS, et al. A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China. Lancet Oncol 2008; 9: 929–936.CrossRefPubMed Qiao YL, Sellors JW, Eder PS, et al. A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China. Lancet Oncol 2008; 9: 929–936.CrossRefPubMed
5.
go back to reference Zhao FH, Lin MJ, Chen F, et al. Performance of high-risk human papillomavirus DNA testing as a primary screen for cervical cancer: a pooled analysis of individual patient data from 17 population-based studies from China. Lancet Oncol 2010; 11: 1160–1171.CrossRefPubMedPubMedCentral Zhao FH, Lin MJ, Chen F, et al. Performance of high-risk human papillomavirus DNA testing as a primary screen for cervical cancer: a pooled analysis of individual patient data from 17 population-based studies from China. Lancet Oncol 2010; 11: 1160–1171.CrossRefPubMedPubMedCentral
6.
go back to reference Pan QJ, Hu SY, Zhang X, et al. Pooled analysis of the performance of liquid-based cytology in population-based cervical cancer screening studies in China. Cancer Cytopathol 2013; 121: 473–482.CrossRefPubMedPubMedCentral Pan QJ, Hu SY, Zhang X, et al. Pooled analysis of the performance of liquid-based cytology in population-based cervical cancer screening studies in China. Cancer Cytopathol 2013; 121: 473–482.CrossRefPubMedPubMedCentral
7.
go back to reference Dong L, Wang MZ, Zhao XL, et al. Human papillomavirus viral load as a useful triage tool for non-16/18 high-risk human papillomavirus positive women: A prospective screening cohort study. Gynecol Oncol 2018; 148(1): 103–110. Dong L, Wang MZ, Zhao XL, et al. Human papillomavirus viral load as a useful triage tool for non-16/18 high-risk human papillomavirus positive women: A prospective screening cohort study. Gynecol Oncol 2018; 148(1): 103–110.
8.
go back to reference Zheng B, Yang H, Li Z, et al. HPV test results and histological follow-up results of patients with LSIL Cervical Cytology from the Largest CAP-certified laboratory in China. J Cancer 2017; 8: 2436–2441.CrossRefPubMedPubMedCentral Zheng B, Yang H, Li Z, et al. HPV test results and histological follow-up results of patients with LSIL Cervical Cytology from the Largest CAP-certified laboratory in China. J Cancer 2017; 8: 2436–2441.CrossRefPubMedPubMedCentral
9.
go back to reference Lv XL, Hou M, Duan XJ. Correlation analysis between the parameters of contrast-enhanced ultrasonography in evaluating cervical cancer metastasis and expression of E-cadherin. Oncol Lett 2017; 14: 4641–4646.CrossRefPubMedPubMedCentral Lv XL, Hou M, Duan XJ. Correlation analysis between the parameters of contrast-enhanced ultrasonography in evaluating cervical cancer metastasis and expression of E-cadherin. Oncol Lett 2017; 14: 4641–4646.CrossRefPubMedPubMedCentral
10.
go back to reference Wei L, Gan Q, Ji T. Cervical cancer histology image identification method based on texture and lesion area features. Comput Assist Surg (Abingdon) 2017; 22: 186–199.CrossRef Wei L, Gan Q, Ji T. Cervical cancer histology image identification method based on texture and lesion area features. Comput Assist Surg (Abingdon) 2017; 22: 186–199.CrossRef
11.
go back to reference Li X, Wang L, Li Y, Song P. The Value of Diffusion-Weighted Imaging in Combination With Conventional Magnetic Resonance Imaging for Improving Tumor Detection for Early Cervical Carcinoma Treated With Fertility-Sparing Surgery. Int J Gynecol Cancer 2017; 27: 1761–1768.CrossRefPubMed Li X, Wang L, Li Y, Song P. The Value of Diffusion-Weighted Imaging in Combination With Conventional Magnetic Resonance Imaging for Improving Tumor Detection for Early Cervical Carcinoma Treated With Fertility-Sparing Surgery. Int J Gynecol Cancer 2017; 27: 1761–1768.CrossRefPubMed
12.
go back to reference Zhang ZJ, Li S. The prognostic value of metformin for cancer patients with concurrent diabetes: a systematic review and meta-analysis. Diabetes Obes Metab 2014; 16: 707–710.CrossRefPubMed Zhang ZJ, Li S. The prognostic value of metformin for cancer patients with concurrent diabetes: a systematic review and meta-analysis. Diabetes Obes Metab 2014; 16: 707–710.CrossRefPubMed
13.
go back to reference Wu SG, Zhang WW, Sun JY, Li FY, He ZY, Zhou J. Multimodal treatment including hysterectomy improves survival in patients with locally advanced cervical cancer: A population-based, propensity score-matched analysis. Int J Surg 2017; 48: 122–127.CrossRefPubMed Wu SG, Zhang WW, Sun JY, Li FY, He ZY, Zhou J. Multimodal treatment including hysterectomy improves survival in patients with locally advanced cervical cancer: A population-based, propensity score-matched analysis. Int J Surg 2017; 48: 122–127.CrossRefPubMed
14.
go back to reference Qi YX, Liu K, Yin J, Li L. Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI. J Cell Biochem 2018; 119(4): 3017–3029. Qi YX, Liu K, Yin J, Li L. Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI. J Cell Biochem 2018; 119(4): 3017–3029.
15.
go back to reference Lei H, Gui D, He Y. Short- and long-term outcomes of laparoscopic radical hysterectomy for obese patients with cervical cancer. J BUON 2017; 22: 958–965.PubMed Lei H, Gui D, He Y. Short- and long-term outcomes of laparoscopic radical hysterectomy for obese patients with cervical cancer. J BUON 2017; 22: 958–965.PubMed
16.
go back to reference Zhang ZJ, Bi Y, Li S, et al. Reduced risk of lung cancer with metformin therapy in diabetic patients: a systematic review and meta-analysis. Am J Epidemiol 2014; 180: 11–14.CrossRefPubMed Zhang ZJ, Bi Y, Li S, et al. Reduced risk of lung cancer with metformin therapy in diabetic patients: a systematic review and meta-analysis. Am J Epidemiol 2014; 180: 11–14.CrossRefPubMed
17.
go back to reference Zhang ZJ, Zheng ZJ, Kan H, et al. Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis. Diabetes Care 2011; 34: 2323–2328.CrossRefPubMedPubMedCentral Zhang ZJ, Zheng ZJ, Kan H, et al. Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis. Diabetes Care 2011; 34: 2323–2328.CrossRefPubMedPubMedCentral
18.
go back to reference Zhang ZJ, Zheng ZJ, Shi R, Su Q, Jiang Q, Kip KE. Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab 2012; 97: 2347–2353.CrossRefPubMed Zhang ZJ, Zheng ZJ, Shi R, Su Q, Jiang Q, Kip KE. Metformin for liver cancer prevention in patients with type 2 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab 2012; 97: 2347–2353.CrossRefPubMed
19.
go back to reference Women’s health in rural China. Lancet 2009; 374: 358. Women’s health in rural China. Lancet 2009; 374: 358.
20.
go back to reference Li WJ, Xu HX, Chen ZH, Xu WD, Wu YJ. Characteristics of carcinogenic human papillomavirus infection in Suzhou: Epidemiology, vaccine evaluation, and associated diseases. J Med Virol 2017; 89: 895–901.CrossRefPubMed Li WJ, Xu HX, Chen ZH, Xu WD, Wu YJ. Characteristics of carcinogenic human papillomavirus infection in Suzhou: Epidemiology, vaccine evaluation, and associated diseases. J Med Virol 2017; 89: 895–901.CrossRefPubMed
21.
go back to reference Xu HH, Lin A, Chen YH, et al. Prevalence characteristics of cervical human papillomavirus (HPV) genotypes in the Taizhou area, China: a cross-sectional study of 37 967 women from the general population. BMJ Open 2017; 7: e014135.CrossRefPubMedPubMedCentral Xu HH, Lin A, Chen YH, et al. Prevalence characteristics of cervical human papillomavirus (HPV) genotypes in the Taizhou area, China: a cross-sectional study of 37 967 women from the general population. BMJ Open 2017; 7: e014135.CrossRefPubMedPubMedCentral
22.
go back to reference Liu X, Bi Y, Wang H, et al. Different Trends of Mortality from Colorectal Cancer between Age Groups in China: An Age-Period-Cohort and Joinpoint Analysis. Public Health 2018; 166: 45–52. Liu X, Bi Y, Wang H, et al. Different Trends of Mortality from Colorectal Cancer between Age Groups in China: An Age-Period-Cohort and Joinpoint Analysis. Public Health 2018; 166: 45–52.
23.
go back to reference Wang L, Yu C, Liu Y, et al. Lung Cancer Mortality Trends in China from 1988 to 2013: New Challenges and Opportunities for the Government. Int J Environ Res Public Health 2016; 13: 1025. Wang L, Yu C, Liu Y, et al. Lung Cancer Mortality Trends in China from 1988 to 2013: New Challenges and Opportunities for the Government. Int J Environ Res Public Health 2016; 13: 1025.
25.
go back to reference Miao J, Wu X. Urbanization, socioeconomic status and health disparity in China. Health Place 2016; 42: 87–95.CrossRefPubMed Miao J, Wu X. Urbanization, socioeconomic status and health disparity in China. Health Place 2016; 42: 87–95.CrossRefPubMed
26.
27.
go back to reference Shen Y, Gong JM, Li YQ, et al. Epidemiology and genotype distribution of human papillomavirus (HPV) in women of Henan Province, China. Clin Chim Acta 2013; 415: 297–301.CrossRefPubMed Shen Y, Gong JM, Li YQ, et al. Epidemiology and genotype distribution of human papillomavirus (HPV) in women of Henan Province, China. Clin Chim Acta 2013; 415: 297–301.CrossRefPubMed
28.
go back to reference Wang R, Guo XL, Wisman GB, et al. Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China. BMC Infect Dis 2015; 15: 257.CrossRefPubMedPubMedCentral Wang R, Guo XL, Wisman GB, et al. Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China. BMC Infect Dis 2015; 15: 257.CrossRefPubMedPubMedCentral
30.
go back to reference Jing L, Zhong X, Zhong Z, et al. Prevalence of human papillomavirus infection in Guangdong Province, China: a population-based survey of 78,355 women. Sex Transm Dis 2014; 41: 732–738.CrossRefPubMed Jing L, Zhong X, Zhong Z, et al. Prevalence of human papillomavirus infection in Guangdong Province, China: a population-based survey of 78,355 women. Sex Transm Dis 2014; 41: 732–738.CrossRefPubMed
31.
go back to reference Chen Z, Wang Q, Ding X, Li Q, Zhong R, Ren H. Characteristics of HPV prevalence in Sichuan Province, China. Int J Gynaecol Obstet 2015; 131: 277–280.CrossRefPubMed Chen Z, Wang Q, Ding X, Li Q, Zhong R, Ren H. Characteristics of HPV prevalence in Sichuan Province, China. Int J Gynaecol Obstet 2015; 131: 277–280.CrossRefPubMed
32.
go back to reference Huang T, Liu Y, Li Y, et al. Evaluation on the persistence of anti-HPV immune responses to the quadrivalent HPV vaccine in Chinese females and males: Up to 3.5years of follow-up. Vaccine 2018; 36: 1368–1374.CrossRefPubMed Huang T, Liu Y, Li Y, et al. Evaluation on the persistence of anti-HPV immune responses to the quadrivalent HPV vaccine in Chinese females and males: Up to 3.5years of follow-up. Vaccine 2018; 36: 1368–1374.CrossRefPubMed
33.
go back to reference Zou H, Meng X, Jia T, et al. Awareness and acceptance of human papillomavirus (HPV) vaccination among males attending a major sexual health clinic in Wuxi, China: A cross-sectional study. Hum Vaccin Immunother 2016; 12: 1551–1559.CrossRefPubMed Zou H, Meng X, Jia T, et al. Awareness and acceptance of human papillomavirus (HPV) vaccination among males attending a major sexual health clinic in Wuxi, China: A cross-sectional study. Hum Vaccin Immunother 2016; 12: 1551–1559.CrossRefPubMed
34.
go back to reference Zou H, Wang W, Ma Y, et al. How university students view human papillomavirus (HPV) vaccination: A cross-sectional study in Jinan, China. Hum Vaccin Immunother 2016; 12: 39–46.CrossRefPubMed Zou H, Wang W, Ma Y, et al. How university students view human papillomavirus (HPV) vaccination: A cross-sectional study in Jinan, China. Hum Vaccin Immunother 2016; 12: 39–46.CrossRefPubMed
35.
go back to reference Wang Z, Wang J, Fang Y, et al. Parental acceptability of HPV vaccination for boys and girls aged 9-13years in China - A population-based study. Vaccine 2018; 36: 2657–2665.CrossRefPubMed Wang Z, Wang J, Fang Y, et al. Parental acceptability of HPV vaccination for boys and girls aged 9-13years in China - A population-based study. Vaccine 2018; 36: 2657–2665.CrossRefPubMed
Metadata
Title
Rising Mortality Rate of Cervical Cancer in Younger Women in Urban China
Authors
Min Wei, MD
Wei Zhou, MS
Yongyi Bi, PhD
Hong Wang, PhD
Yu Liu, PhD
Zhi-Jiang Zhang, PhD
Publication date
01-02-2019
Publisher
Springer US
Published in
Journal of General Internal Medicine / Issue 2/2019
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-018-4732-z

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