Skip to main content
Top
Published in: Journal of General Internal Medicine 12/2017

01-12-2017 | Original Research

Hospitalization Risk and Potentially Inappropriate Medications among Medicare Home Health Nursing Patients

Authors: Matthew C. Lohman, PhD, Brandi P. Cotton, PhD, Alexandra B. Zagaria, BA, Yuhua Bao, PhD, Rebecca L. Greenberg, MS, Karen L. Fortuna, PhD, Martha L. Bruce, PhD

Published in: Journal of General Internal Medicine | Issue 12/2017

Login to get access

Abstract

Background

Hospitalizations and potentially inappropriate medication (PIM) use are significant and costly issues among older home health patients, yet little is known about the prevalence of PIM use in home health or the relationship between PIM use and hospitalization risk in this population.

Objective

To describe the prevalence of PIM use and association with hospitalization among Medicare home health patients.

Design

Cross-sectional analysis using data from 132 home health agencies in the US.

Subjects

Medicare beneficiaries starting home health nursing services between 2013 and 2014 (n = 87,780).

Main Measures

Prevalence of individual and aggregate PIM use at start of care, measured using the 2012 Beers criteria. Relative risk (RR) of 30-day hospitalization or re-hospitalization associated with individual and aggregate PIM use, compared to no PIM use.

Key Results

In total, 30,168 (34.4%) patients were using at least one PIM, with 5969 (6.8%) taking at least two PIMs according to the Beers list. The most common types of PIMs were those affecting the brain or spinal cord, analgesics, and medications with anticholinergic properties. With the exception of nonsteroidal anti-inflammatory drugs (NSAIDs), PIM use across all classes was associated with elevated risk (10–33%) of hospitalization compared to non-use. Adjusting for demographic and clinical characteristics, patients using at least one PIM (excluding NSAIDs) had a 13% greater risk (RR = 1.13, 95% CI: 1.09, 1.17) of being hospitalized than patients using no PIMs, while patients using at least two PIMs had 21% greater risk (RR = 1.21, 95% CI: 1.12, 1.30). Similar associations were found between PIMs and re-hospitalization risk among patients referred to home health from a hospital.

Conclusions

Given the high prevalence of PIM use and the association between PIMs and hospitalization risk, home health episodes represent opportunities to substantially reduce PIM use among older adults and prevent adverse outcomes. Efforts to address medication use during home health episodes, hospitalizations, and care transitions are justified.
Literature
3.
go back to reference Fortinsky RH, Madigan EA, Sheehan TJ, Tullai-McGuinness S, Kleppinger A. Risk factors for hospitalization in a national sample of medicare home health care patients. J Appl Gerontol. 2014;33(4):474–93.CrossRefPubMed Fortinsky RH, Madigan EA, Sheehan TJ, Tullai-McGuinness S, Kleppinger A. Risk factors for hospitalization in a national sample of medicare home health care patients. J Appl Gerontol. 2014;33(4):474–93.CrossRefPubMed
4.
go back to reference American Geriatrics Society. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31.CrossRef American Geriatrics Society. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60(4):616–31.CrossRef
5.
go back to reference Chutka DS, Takahashi PY, Hoel RW. Inappropriate medications for elderly patients. Mayo Clin Proc. 2004;79(1):122–39.CrossRefPubMed Chutka DS, Takahashi PY, Hoel RW. Inappropriate medications for elderly patients. Mayo Clin Proc. 2004;79(1):122–39.CrossRefPubMed
6.
go back to reference McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56(2):163–84.CrossRefPubMed McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56(2):163–84.CrossRefPubMed
7.
go back to reference Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem. 2010;17(6):571–84.CrossRefPubMed Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem. 2010;17(6):571–84.CrossRefPubMed
8.
go back to reference Nguyen JK, Fouts MM, Kotabe SE, Lo E. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother. 2006;4(1):36–41.CrossRefPubMed Nguyen JK, Fouts MM, Kotabe SE, Lo E. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother. 2006;4(1):36–41.CrossRefPubMed
9.
go back to reference Huang AR, Mallet L, Rochefort CM, Eguale T, Buckeridge DL, Tamblyn R. Medication-related falls in the elderly: causative factors and preventive strategies. Drugs Aging. 2012;29(5):359–76.CrossRefPubMed Huang AR, Mallet L, Rochefort CM, Eguale T, Buckeridge DL, Tamblyn R. Medication-related falls in the elderly: causative factors and preventive strategies. Drugs Aging. 2012;29(5):359–76.CrossRefPubMed
10.
go back to reference Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, et al. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int. 2012;12(3):425–30.CrossRefPubMed Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, et al. Polypharmacy as a risk for fall occurrence in geriatric outpatients. Geriatr Gerontol Int. 2012;12(3):425–30.CrossRefPubMed
11.
go back to reference Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, et al. A drug burden index to define the functional burden of medications in older people. Arch Intern Med. 2007;167(8):781–7.CrossRefPubMed Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, et al. A drug burden index to define the functional burden of medications in older people. Arch Intern Med. 2007;167(8):781–7.CrossRefPubMed
12.
go back to reference Tinetti ME, Han L, Lee DS, McAvay GJ, Peduzzi P, Gross CP, et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med. 2014;174(4):588–95.CrossRefPubMedPubMedCentral Tinetti ME, Han L, Lee DS, McAvay GJ, Peduzzi P, Gross CP, et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med. 2014;174(4):588–95.CrossRefPubMedPubMedCentral
13.
go back to reference Wong J, Marr P, Kwan D, Meiyappan S, Adcock L. Identification of inappropriate medication use in elderly patients with frequent emergency department visits. Can Pharm J (Ott). 2014;147(4):248–56.CrossRef Wong J, Marr P, Kwan D, Meiyappan S, Adcock L. Identification of inappropriate medication use in elderly patients with frequent emergency department visits. Can Pharm J (Ott). 2014;147(4):248–56.CrossRef
14.
go back to reference Beijer HJ, de Blaey CJ. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci. 2002;24(2):46–54.CrossRefPubMed Beijer HJ, de Blaey CJ. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci. 2002;24(2):46–54.CrossRefPubMed
15.
go back to reference Bao Y, Shao H, Bishop TF, Schackman BR, Bruce ML. Inappropriate medication in a national sample of US elderly patients receiving home health care. J Gen Intern Med. 2012;27(3):304–10.CrossRefPubMed Bao Y, Shao H, Bishop TF, Schackman BR, Bruce ML. Inappropriate medication in a national sample of US elderly patients receiving home health care. J Gen Intern Med. 2012;27(3):304–10.CrossRefPubMed
16.
go back to reference Goulding MR. Inappropriate medication prescribing for elderly ambulatory care patients. Arch Intern Med. 2004;164(3):305–12.CrossRefPubMed Goulding MR. Inappropriate medication prescribing for elderly ambulatory care patients. Arch Intern Med. 2004;164(3):305–12.CrossRefPubMed
17.
go back to reference Viswanathan H, Bharmal M, Thomas J, 3rd. Prevalence and correlates of potentially inappropriate prescribing among ambulatory older patients in the year 2001: comparison of three explicit criteria. Clin Ther. 2005;27(1):88–99.CrossRefPubMed Viswanathan H, Bharmal M, Thomas J, 3rd. Prevalence and correlates of potentially inappropriate prescribing among ambulatory older patients in the year 2001: comparison of three explicit criteria. Clin Ther. 2005;27(1):88–99.CrossRefPubMed
18.
go back to reference Lau DT, Kasper JD, Potter DE, Lyles A. Potentially inappropriate medication prescriptions among elderly nursing home residents: their scope and associated resident and facility characteristics. Health Serv Res. 2004;39(5):1257–76.CrossRefPubMedPubMedCentral Lau DT, Kasper JD, Potter DE, Lyles A. Potentially inappropriate medication prescriptions among elderly nursing home residents: their scope and associated resident and facility characteristics. Health Serv Res. 2004;39(5):1257–76.CrossRefPubMedPubMedCentral
19.
go back to reference Wimmer BC, Cross AJ, Jokanovic N, Wiese MD, George J, Johnell K, et al. Clinical Outcomes Associated with Medication Regimen Complexity in Older People: A Systematic Review. J Am Geriatr Soc. 2017;65(4):747–53.CrossRefPubMed Wimmer BC, Cross AJ, Jokanovic N, Wiese MD, George J, Johnell K, et al. Clinical Outcomes Associated with Medication Regimen Complexity in Older People: A Systematic Review. J Am Geriatr Soc. 2017;65(4):747–53.CrossRefPubMed
20.
go back to reference Lang A, Macdonald M, Marck P, Toon L, Griffin M, Easty T, et al. Seniors managing multiple medications: using mixed methods to view the home care safety lens. BMC Health Serv Res. 2015;15:548.CrossRefPubMedPubMedCentral Lang A, Macdonald M, Marck P, Toon L, Griffin M, Easty T, et al. Seniors managing multiple medications: using mixed methods to view the home care safety lens. BMC Health Serv Res. 2015;15:548.CrossRefPubMedPubMedCentral
21.
go back to reference Olson CH, Dierich M, Westra BL. Automation of a high risk medication regime algorithm in a home health care population. J Biomed Inform. 2014;51:60–71.CrossRefPubMed Olson CH, Dierich M, Westra BL. Automation of a high risk medication regime algorithm in a home health care population. J Biomed Inform. 2014;51:60–71.CrossRefPubMed
24.
go back to reference Covinsky KE, Palmer RM, Fortinsky RH, Counsell SR, Stewart AL, Kresevic D, et al. Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age. J Am Geriatr Soc 2003;51(4):451–8.CrossRefPubMed Covinsky KE, Palmer RM, Fortinsky RH, Counsell SR, Stewart AL, Kresevic D, et al. Loss of independence in activities of daily living in older adults hospitalized with medical illnesses: increased vulnerability with age. J Am Geriatr Soc 2003;51(4):451–8.CrossRefPubMed
25.
go back to reference Mudge AM, O’Rourke P, Denaro CP. Timing and risk factors for functional changes associated with medical hospitalization in older patients. J Gerontol A Biol Sci Med Sci. 2010;65(8):866–72.CrossRefPubMed Mudge AM, O’Rourke P, Denaro CP. Timing and risk factors for functional changes associated with medical hospitalization in older patients. J Gerontol A Biol Sci Med Sci. 2010;65(8):866–72.CrossRefPubMed
26.
go back to reference Patient Protection and Affordable Care Act. Sect. 3025. 2010. Patient Protection and Affordable Care Act. Sect. 3025. 2010.
29.
go back to reference Naylor MD, Aiken LH, Kurtzman ET, Olds DM, Hirschman KB. The care span: The importance of transitional care in achieving health reform. Health Aff (Millwood). 2011;30(4):746–54.CrossRef Naylor MD, Aiken LH, Kurtzman ET, Olds DM, Hirschman KB. The care span: The importance of transitional care in achieving health reform. Health Aff (Millwood). 2011;30(4):746–54.CrossRef
30.
go back to reference Jack BW, Chetty VK, Anthony D, Greenwald JL, Sanchez GM, Johnson AE, et al. A reengineered hospital discharge program to decrease rehospitalization: a randomized trial. Ann Intern Med. 2009;150(3):178–87.CrossRefPubMedPubMedCentral Jack BW, Chetty VK, Anthony D, Greenwald JL, Sanchez GM, Johnson AE, et al. A reengineered hospital discharge program to decrease rehospitalization: a randomized trial. Ann Intern Med. 2009;150(3):178–87.CrossRefPubMedPubMedCentral
31.
go back to reference Koehler BE, Richter KM, Youngblood L, Cohen BA, Prengler ID, Cheng D, et al. Reduction of 30-day postdischarge hospital readmission or emergency department (ED) visit rates in high-risk elderly medical patients through delivery of a targeted care bundle. J Hosp Med. 2009;4(4):211–8.CrossRefPubMed Koehler BE, Richter KM, Youngblood L, Cohen BA, Prengler ID, Cheng D, et al. Reduction of 30-day postdischarge hospital readmission or emergency department (ED) visit rates in high-risk elderly medical patients through delivery of a targeted care bundle. J Hosp Med. 2009;4(4):211–8.CrossRefPubMed
32.
go back to reference Zillich AJ, Snyder ME, Frail CK, Lewis JL, Deshotels D, Dunham P, et al. A randomized, controlled pragmatic trial of telephonic medication therapy management to reduce hospitalization in home health patients. Health Serv Res. 2014;49(5):1537–54.CrossRefPubMedPubMedCentral Zillich AJ, Snyder ME, Frail CK, Lewis JL, Deshotels D, Dunham P, et al. A randomized, controlled pragmatic trial of telephonic medication therapy management to reduce hospitalization in home health patients. Health Serv Res. 2014;49(5):1537–54.CrossRefPubMedPubMedCentral
34.
go back to reference Lohman MC, Scherer EA, Whiteman KL, Greenberg RL, Bruce ML. Factors Associated With Accelerated Hospitalization and Re-hospitalization Among Medicare Home Health Patients. J Gerontol A Biol Sci Med Sci. 2017. Lohman MC, Scherer EA, Whiteman KL, Greenberg RL, Bruce ML. Factors Associated With Accelerated Hospitalization and Re-hospitalization Among Medicare Home Health Patients. J Gerontol A Biol Sci Med Sci. 2017.
36.
go back to reference Kroenke K, Spitzer RL, Williams JB. The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care. 2003;41(11):1284–92.CrossRefPubMed Kroenke K, Spitzer RL, Williams JB. The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care. 2003;41(11):1284–92.CrossRefPubMed
37.
go back to reference Bruce ML, Lohman MC, Greenberg RL, Bao Y, Raue PJ. Integrating Depression Care Management into Medicare Home Health Reduces Risk of 30- and 60-Day Hospitalization: The Depression Care for Patients at Home Cluster-Randomized Trial. J Am Geriatr Soc. 2016;64(11):2196–203.CrossRefPubMedPubMedCentral Bruce ML, Lohman MC, Greenberg RL, Bao Y, Raue PJ. Integrating Depression Care Management into Medicare Home Health Reduces Risk of 30- and 60-Day Hospitalization: The Depression Care for Patients at Home Cluster-Randomized Trial. J Am Geriatr Soc. 2016;64(11):2196–203.CrossRefPubMedPubMedCentral
39.
go back to reference Cannon KT, Choi MM, Zuniga MA. Potentially inappropriate medication use in elderly patients receiving home health care: a retrospective data analysis. Am J Geriatr Pharmacother. 2006;4(2):134–43.CrossRefPubMed Cannon KT, Choi MM, Zuniga MA. Potentially inappropriate medication use in elderly patients receiving home health care: a retrospective data analysis. Am J Geriatr Pharmacother. 2006;4(2):134–43.CrossRefPubMed
40.
go back to reference Miller GE, Sarpong EM, Davidoff AJ, Yang EY, Brandt NJ, Fick DM. Determinants of Potentially Inappropriate Medication Use among Community-Dwelling Older Adults. Health Serv Res. 2016. Miller GE, Sarpong EM, Davidoff AJ, Yang EY, Brandt NJ, Fick DM. Determinants of Potentially Inappropriate Medication Use among Community-Dwelling Older Adults. Health Serv Res. 2016.
41.
go back to reference Gallagher PF, Barry PJ, Ryan C, Hartigan I, O’Mahony D. Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers’ Criteria. Age Ageing. 2008;37(1):96–101.CrossRefPubMed Gallagher PF, Barry PJ, Ryan C, Hartigan I, O’Mahony D. Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers’ Criteria. Age Ageing. 2008;37(1):96–101.CrossRefPubMed
42.
go back to reference Budnitz DS, Shehab N, Kegler SR, Richards CL. Medication use leading to emergency department visits for adverse drug events in older adults. Ann Intern Med. 2007;147(11):755–65.CrossRefPubMed Budnitz DS, Shehab N, Kegler SR, Richards CL. Medication use leading to emergency department visits for adverse drug events in older adults. Ann Intern Med. 2007;147(11):755–65.CrossRefPubMed
44.
go back to reference Ni Chroinin D, Neto HM, Xiao D, Sandhu A, Brazel C, Farnham N, et al. Potentially inappropriate medications (PIMs) in older hospital in-patients: Prevalence, contribution to hospital admission and documentation of rationale for continuation. Australas J Ageing. 2016;35(4):262–5.CrossRefPubMed Ni Chroinin D, Neto HM, Xiao D, Sandhu A, Brazel C, Farnham N, et al. Potentially inappropriate medications (PIMs) in older hospital in-patients: Prevalence, contribution to hospital admission and documentation of rationale for continuation. Australas J Ageing. 2016;35(4):262–5.CrossRefPubMed
45.
go back to reference Brody AA, Gibson B, Tresner-Kirsch D, Kramer H, Thraen I, Coarr ME, et al. High prevalence of medication discrepancies between home health referrals and Centers for Medicare and Medicaid Services home health certification and plan of care and their potential to affect safety of vulnerable elderly adults. J Am Geriatr Soc. 2016;64(11):e166-e70.CrossRefPubMed Brody AA, Gibson B, Tresner-Kirsch D, Kramer H, Thraen I, Coarr ME, et al. High prevalence of medication discrepancies between home health referrals and Centers for Medicare and Medicaid Services home health certification and plan of care and their potential to affect safety of vulnerable elderly adults. J Am Geriatr Soc. 2016;64(11):e166-e70.CrossRefPubMed
46.
go back to reference Brown EL, Raue PJ, Mlodzianowski AE, Meyers BS, Greenberg RL, Bruce ML. Transition to home care: quality of mental health, pharmacy, and medical history information. Int J Psychiatry Med. 2006;36(3):339–49.CrossRefPubMed Brown EL, Raue PJ, Mlodzianowski AE, Meyers BS, Greenberg RL, Bruce ML. Transition to home care: quality of mental health, pharmacy, and medical history information. Int J Psychiatry Med. 2006;36(3):339–49.CrossRefPubMed
47.
go back to reference Delate T, Chester EA, Stubbings TW, Barnes CA. Clinical outcomes of a home-based medication reconciliation program after discharge from a skilled nursing facility. Pharmacotherapy. 2008;28(4):444–52.CrossRefPubMed Delate T, Chester EA, Stubbings TW, Barnes CA. Clinical outcomes of a home-based medication reconciliation program after discharge from a skilled nursing facility. Pharmacotherapy. 2008;28(4):444–52.CrossRefPubMed
48.
go back to reference Setter SM, Corbett CF, Neumiller JJ, Gates BJ, Sclar DA, Sonnett TE. Effectiveness of a pharmacist-nurse intervention on resolving medication discrepancies for patients transitioning from hospital to home health care. Am J Health Syst Pharm. 2009;66(22):2027–31.CrossRefPubMed Setter SM, Corbett CF, Neumiller JJ, Gates BJ, Sclar DA, Sonnett TE. Effectiveness of a pharmacist-nurse intervention on resolving medication discrepancies for patients transitioning from hospital to home health care. Am J Health Syst Pharm. 2009;66(22):2027–31.CrossRefPubMed
49.
go back to reference Siegler EL, Murtaugh CM, Rosati RJ, Clark A, Ruchlin HS, Sobolewski S, et al. Improving the transition to home healthcare by rethinking the purpose and structure of the CMS 485: first steps. Home Health Care Serv Q. 2006;25(3–4):27–38.CrossRefPubMed Siegler EL, Murtaugh CM, Rosati RJ, Clark A, Ruchlin HS, Sobolewski S, et al. Improving the transition to home healthcare by rethinking the purpose and structure of the CMS 485: first steps. Home Health Care Serv Q. 2006;25(3–4):27–38.CrossRefPubMed
Metadata
Title
Hospitalization Risk and Potentially Inappropriate Medications among Medicare Home Health Nursing Patients
Authors
Matthew C. Lohman, PhD
Brandi P. Cotton, PhD
Alexandra B. Zagaria, BA
Yuhua Bao, PhD
Rebecca L. Greenberg, MS
Karen L. Fortuna, PhD
Martha L. Bruce, PhD
Publication date
01-12-2017
Publisher
Springer US
Published in
Journal of General Internal Medicine / Issue 12/2017
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-017-4157-0

Other articles of this Issue 12/2017

Journal of General Internal Medicine 12/2017 Go to the issue