Skip to main content
Top
Published in: Journal of General Internal Medicine 4/2015

01-04-2015 | Original Research

Gender, Race, and Variation in the Evaluation of Microscopic Hematuria Among Medicare Beneficiaries

Authors: Jeffrey C. Bassett, MD, MPH, JoAnn Alvarez, MA, Tatsuki Koyama, PhD, Matthew Resnick, MD, Chaochen You, MD, Shenghua Ni, PhD, David F. Penson, MD, MPH, Daniel A. Barocas, MD, MPH

Published in: Journal of General Internal Medicine | Issue 4/2015

Login to get access

ABSTRACT

BACKGROUND

Female gender and black race are associated with delayed diagnosis and inferior survival in patients with bladder cancer.

OBJECTIVE

We aimed to determine the association between gender, race, and evaluation of microscopic hematuria (an early sign of bladder cancer).

DESIGN AND PARTICIPANTS

This was a cohort study using a 5 % random sample of fee-for-service Medicare beneficiaries diagnosed with incident hematuria (International Classification of Diseases, Ninth Revision [ICD-9] code 599.7x) between January 2009 and June 2010 in a primary care setting. Beneficiaries with pre-existing explanatory diagnoses or genitourinary procedures were excluded.

MAIN MEASURES

The main endpoint was completeness of the hematuria evaluation in the 180 days after diagnosis. Evaluations were categorized as complete, incomplete, or absent based on receipt of relevant diagnostic procedures and imaging studies.

KEY RESULTS

In all, 9,211 beneficiaries met the study criteria. Hematuria evaluations were complete in 14 %, incomplete in 21 %, and absent in 65 % of subjects. Compared to males, females were less likely to have a procedure (26 vs. 12 %), imaging (41 vs. 30 %), and a complete evaluation (22 vs. 10 %) (p < 0.001 for each comparison). Receipt of a complete evaluation did not differ by race. Controlling for baseline characteristics, a complete evaluation was less likely in white women (OR, 0.40 [95 % CI, 0.35–0.46]) and black women (OR, 0.46 [95 % CI, 0.29–0.70]) compared to white men; no difference was found between black and white men.

CONCLUSIONS

Women are less likely than men to undergo a complete and timely hematuria evaluation, a finding likely relevant to women’s more advanced stage at bladder cancer diagnosis. System-level process improvement between providers of urologic and primary care in the evaluation of hematuria may benefit women harboring malignancy.
Appendix
Available only for authorised users
Literature
2.
go back to reference Mohr DN, Offord KP, Owen RA, Melton LJ 3rd. Asymptomatic microhematuria and urologic disease. A population-based study. JAMA. 1986;256(2):224–9.CrossRefPubMed Mohr DN, Offord KP, Owen RA, Melton LJ 3rd. Asymptomatic microhematuria and urologic disease. A population-based study. JAMA. 1986;256(2):224–9.CrossRefPubMed
3.
go back to reference Mariani AJ, Mariani MC, Macchioni C, Stams UK, Hariharan A, Moriera A. The significance of adult hematuria: 1,000 hematuria evaluations including a risk-benefit and cost-effectiveness analysis. J Urol. 1989;141(2):350–5.PubMed Mariani AJ, Mariani MC, Macchioni C, Stams UK, Hariharan A, Moriera A. The significance of adult hematuria: 1,000 hematuria evaluations including a risk-benefit and cost-effectiveness analysis. J Urol. 1989;141(2):350–5.PubMed
4.
go back to reference Messing EM, Young TB, Hunt VB, Wehbie JM, Rust P. Urinary tract cancers found by homescreening with hematuria dipsticks in healthy men over 50 years of age. Cancer. 1989;64(11):2361–7.CrossRefPubMed Messing EM, Young TB, Hunt VB, Wehbie JM, Rust P. Urinary tract cancers found by homescreening with hematuria dipsticks in healthy men over 50 years of age. Cancer. 1989;64(11):2361–7.CrossRefPubMed
5.
go back to reference Sultana SR, Goodman CM, Byrne DJ, Baxby K. Microscopic haematuria: urological investigation using a standard protocol. Br J Urol. 1996;78(5):691–696. discussion 697–8.CrossRefPubMed Sultana SR, Goodman CM, Byrne DJ, Baxby K. Microscopic haematuria: urological investigation using a standard protocol. Br J Urol. 1996;78(5):691–696. discussion 697–8.CrossRefPubMed
6.
go back to reference Khadra MH, Pickard RS, Charlton M, Powell PH, Neal DE. A prospective analysis of 1,930 patients with hematuria to evaluate current diagnostic practice. J Urol. 2000;163(2):524–7.CrossRefPubMed Khadra MH, Pickard RS, Charlton M, Powell PH, Neal DE. A prospective analysis of 1,930 patients with hematuria to evaluate current diagnostic practice. J Urol. 2000;163(2):524–7.CrossRefPubMed
7.
go back to reference Grossfeld GD, Litwin MS, Wolf JS Jr, et al. Evaluation of asymptomatic microscopic hematuria in adults: the American Urological Association best practice policy-part II: patient evaluation, cytology, voided markers, imaging, cystoscopy, nephrology evaluation, and follow-up. Urology. 2001;57(4):604–10.CrossRefPubMed Grossfeld GD, Litwin MS, Wolf JS Jr, et al. Evaluation of asymptomatic microscopic hematuria in adults: the American Urological Association best practice policy-part II: patient evaluation, cytology, voided markers, imaging, cystoscopy, nephrology evaluation, and follow-up. Urology. 2001;57(4):604–10.CrossRefPubMed
8.
go back to reference Davis R, Jones JS, Barocas DA, et al. Diagnosis, evaluation and follow-up of asymptomatic microhematuria (AMH) in adults: AUA guideline. J Urol. 2012;188(6 Suppl):2473–81.CrossRefPubMed Davis R, Jones JS, Barocas DA, et al. Diagnosis, evaluation and follow-up of asymptomatic microhematuria (AMH) in adults: AUA guideline. J Urol. 2012;188(6 Suppl):2473–81.CrossRefPubMed
9.
go back to reference Buteau A, Seideman CA, Svatek RS, et al. What is evaluation of hematuria by primary care physicians? Use of electronic medical records to assess practice patterns with intermediate follow-up. Urol Oncol. 2014;32(2):128–34.CrossRefPubMed Buteau A, Seideman CA, Svatek RS, et al. What is evaluation of hematuria by primary care physicians? Use of electronic medical records to assess practice patterns with intermediate follow-up. Urol Oncol. 2014;32(2):128–34.CrossRefPubMed
10.
go back to reference Friedlander DF, Resnick MJ, You C, et al. Variation in the Intensity of Hematuria Evaluation: A Target for Primary Care Quality Improvement. Am J Med. Jan 28 2014. Friedlander DF, Resnick MJ, You C, et al. Variation in the Intensity of Hematuria Evaluation: A Target for Primary Care Quality Improvement. Am J Med. Jan 28 2014.
11.
go back to reference Elias K, Svatek RS, Gupta S, Ho R, Lotan Y. High-risk patients with hematuria are not evaluated according to guideline recommendations. Cancer. 2010;116(12):2954–9.CrossRefPubMedCentralPubMed Elias K, Svatek RS, Gupta S, Ho R, Lotan Y. High-risk patients with hematuria are not evaluated according to guideline recommendations. Cancer. 2010;116(12):2954–9.CrossRefPubMedCentralPubMed
12.
go back to reference Hollenbeck BK, Dunn RL, Ye Z, et al. Delays in diagnosis and bladder cancer mortality. Cancer. 2010;116(22):5235–42.CrossRefPubMed Hollenbeck BK, Dunn RL, Ye Z, et al. Delays in diagnosis and bladder cancer mortality. Cancer. 2010;116(22):5235–42.CrossRefPubMed
13.
go back to reference Cohn JA, Vekhter B, Lyttle C, Steinberg GD, Large MC. Sex disparities in diagnosis of bladder cancer after initial presentation with hematuria: A nationwide claims-based investigation. Cancer. 2014;120(4):555–61.CrossRefPubMedCentralPubMed Cohn JA, Vekhter B, Lyttle C, Steinberg GD, Large MC. Sex disparities in diagnosis of bladder cancer after initial presentation with hematuria: A nationwide claims-based investigation. Cancer. 2014;120(4):555–61.CrossRefPubMedCentralPubMed
14.
go back to reference Klabunde CN, Potosky AL, Legler JM, Warren JL. Development of a comorbidity index using physician claims data. J Clin Epidemiol. 2000;53(12):1258–67.CrossRefPubMed Klabunde CN, Potosky AL, Legler JM, Warren JL. Development of a comorbidity index using physician claims data. J Clin Epidemiol. 2000;53(12):1258–67.CrossRefPubMed
15.
go back to reference Krieger N. Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. Am J Public Health. 1992;82(5):703–10.CrossRefPubMedCentralPubMed Krieger N. Overcoming the absence of socioeconomic data in medical records: validation and application of a census-based methodology. Am J Public Health. 1992;82(5):703–10.CrossRefPubMedCentralPubMed
16.
go back to reference Krieger N, Williams DR, Moss NE. Measuring social class in US public health research: concepts, methodologies, and guidelines. Annu Rev Public Health. 1997;18:341–78.CrossRefPubMed Krieger N, Williams DR, Moss NE. Measuring social class in US public health research: concepts, methodologies, and guidelines. Annu Rev Public Health. 1997;18:341–78.CrossRefPubMed
18.
go back to reference Prout GR Jr, Wesley MN, Greenberg RS, et al. Bladder cancer: race differences in extent of disease at diagnosis. Cancer. 2000;89(6):1349–58.CrossRefPubMed Prout GR Jr, Wesley MN, Greenberg RS, et al. Bladder cancer: race differences in extent of disease at diagnosis. Cancer. 2000;89(6):1349–58.CrossRefPubMed
19.
go back to reference Cardenas-Turanzas M, Cooksley C, Pettaway CA, Sabichi A, Grossman HB, Elting L. Comparative outcomes of bladder cancer. Obstet Gynecol. 2006;108(1):169–75.CrossRefPubMed Cardenas-Turanzas M, Cooksley C, Pettaway CA, Sabichi A, Grossman HB, Elting L. Comparative outcomes of bladder cancer. Obstet Gynecol. 2006;108(1):169–75.CrossRefPubMed
20.
go back to reference Lee CT, Dunn RL, Williams C, Underwood W 3rd. Racial disparity in bladder cancer: trends in tumor presentation at diagnosis. J Urol. Sep. 2006;176(3):927–933. discussion 933–24.CrossRef Lee CT, Dunn RL, Williams C, Underwood W 3rd. Racial disparity in bladder cancer: trends in tumor presentation at diagnosis. J Urol. Sep. 2006;176(3):927–933. discussion 933–24.CrossRef
21.
go back to reference Mallin K, David KA, Carroll PR, Milowsky MI, Nanus DM. Transitional cell carcinoma of the bladder: racial and gender disparities in survival (1993 to 2002), stage and grade (1993 to 2007). J Urol. May. 2011;185(5):1631–6.CrossRef Mallin K, David KA, Carroll PR, Milowsky MI, Nanus DM. Transitional cell carcinoma of the bladder: racial and gender disparities in survival (1993 to 2002), stage and grade (1993 to 2007). J Urol. May. 2011;185(5):1631–6.CrossRef
22.
go back to reference Mungan NA, Aben KK, Schoenberg MP, et al. Gender differences in stage-adjusted bladder cancer survival. Urology. 2000;55(6):876–80.CrossRefPubMed Mungan NA, Aben KK, Schoenberg MP, et al. Gender differences in stage-adjusted bladder cancer survival. Urology. 2000;55(6):876–80.CrossRefPubMed
23.
go back to reference Scosyrev E, Noyes K, Feng C, Messing E. Sex and racial differences in bladder cancer presentation and mortality in the US. Cancer. 2009;115(1):68–74.CrossRefPubMed Scosyrev E, Noyes K, Feng C, Messing E. Sex and racial differences in bladder cancer presentation and mortality in the US. Cancer. 2009;115(1):68–74.CrossRefPubMed
24.
go back to reference Institute of Medicine. Coverage Matters: Insurance and Health Care. Washington: National Academies Press; 2001. Institute of Medicine. Coverage Matters: Insurance and Health Care. Washington: National Academies Press; 2001.
25.
go back to reference Institute of Medicine. Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care. Washington: National Academies Press; 2002. Institute of Medicine. Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care. Washington: National Academies Press; 2002.
26.
go back to reference Prout GR Jr, Wesley MN, McCarron PG, et al. Survival experience of black patients and white patients with bladder carcinoma. Cancer. 2004;100(3):621–30.CrossRefPubMed Prout GR Jr, Wesley MN, McCarron PG, et al. Survival experience of black patients and white patients with bladder carcinoma. Cancer. 2004;100(3):621–30.CrossRefPubMed
27.
go back to reference Bach PB, Schrag D, Brawley OW, Galaznik A, Yakren S, Begg CB. Survival of blacks and whites after a cancer diagnosis. JAMA. 2002;287(16):2106–13.CrossRefPubMed Bach PB, Schrag D, Brawley OW, Galaznik A, Yakren S, Begg CB. Survival of blacks and whites after a cancer diagnosis. JAMA. 2002;287(16):2106–13.CrossRefPubMed
28.
go back to reference Taub DA, Hollenbeck BK, Cooper KL, et al. Racial disparities in resource utilization for cystectomy. Urology. 2006;67(2):288–93.CrossRefPubMed Taub DA, Hollenbeck BK, Cooper KL, et al. Racial disparities in resource utilization for cystectomy. Urology. 2006;67(2):288–93.CrossRefPubMed
29.
go back to reference Konety BR, Allareddy V, Carroll PR. Factors affecting outcomes after radical cystectomy in African Americans. Cancer. 2007;109(3):542–8.CrossRefPubMed Konety BR, Allareddy V, Carroll PR. Factors affecting outcomes after radical cystectomy in African Americans. Cancer. 2007;109(3):542–8.CrossRefPubMed
30.
go back to reference Barocas DA, Alvarez J, Koyama T, et al. Racial variation in the quality of surgical care for bladder cancer. Cancer. 2014;120(7):1018–25.CrossRefPubMed Barocas DA, Alvarez J, Koyama T, et al. Racial variation in the quality of surgical care for bladder cancer. Cancer. 2014;120(7):1018–25.CrossRefPubMed
31.
go back to reference Konety BR, Joslyn SA. Factors influencing aggressive therapy for bladder cancer: an analysis of data from the SEER program. J Urol. 2003;170(5):1765–71.CrossRefPubMed Konety BR, Joslyn SA. Factors influencing aggressive therapy for bladder cancer: an analysis of data from the SEER program. J Urol. 2003;170(5):1765–71.CrossRefPubMed
32.
go back to reference Fedeli U, Fedewa SA, Ward EM. Treatment of muscle invasive bladder cancer: evidence from the National Cancer Database, 2003 to 2007. J Urol. 2011;185(1):72–8.CrossRefPubMed Fedeli U, Fedewa SA, Ward EM. Treatment of muscle invasive bladder cancer: evidence from the National Cancer Database, 2003 to 2007. J Urol. 2011;185(1):72–8.CrossRefPubMed
33.
go back to reference Franks P, Zwanziger J, Mooney C, Sorbero M. Variations in primary care physician referral rates. Health Serv Res. 1999;34(1 Pt 2):323–9.PubMedCentralPubMed Franks P, Zwanziger J, Mooney C, Sorbero M. Variations in primary care physician referral rates. Health Serv Res. 1999;34(1 Pt 2):323–9.PubMedCentralPubMed
34.
go back to reference Franks P, Williams GC, Zwanziger J, Mooney C, Sorbero M. Why do physicians vary so widely in their referral rates? J Gen Intern Med. 2000;15(3):163–8.CrossRefPubMedCentralPubMed Franks P, Williams GC, Zwanziger J, Mooney C, Sorbero M. Why do physicians vary so widely in their referral rates? J Gen Intern Med. 2000;15(3):163–8.CrossRefPubMedCentralPubMed
35.
36.
go back to reference Johnson EK, Daignault S, Zhang Y, Lee CT. Patterns of hematuria referral to urologists: does a gender disparity exist? Urology. 2008;72(3):498–502. discussion 502–493.CrossRefPubMed Johnson EK, Daignault S, Zhang Y, Lee CT. Patterns of hematuria referral to urologists: does a gender disparity exist? Urology. 2008;72(3):498–502. discussion 502–493.CrossRefPubMed
37.
go back to reference Lyratzopoulos G, Abel GA, McPhail S, Neal RD, Rubin GP. Gender inequalities in the promptness of diagnosis of bladder and renal cancer after symptomatic presentation: evidence from secondary analysis of an English primary care audit survey. BMJ Open. 2013;3(6). Lyratzopoulos G, Abel GA, McPhail S, Neal RD, Rubin GP. Gender inequalities in the promptness of diagnosis of bladder and renal cancer after symptomatic presentation: evidence from secondary analysis of an English primary care audit survey. BMJ Open. 2013;3(6).
38.
go back to reference Miller DC, Murtagh DS, Suh RS, et al. Regional collaboration to improve radiographic staging practices among men with early stage prostate cancer. J Urol. 2011;186(3):844–9.CrossRefPubMed Miller DC, Murtagh DS, Suh RS, et al. Regional collaboration to improve radiographic staging practices among men with early stage prostate cancer. J Urol. 2011;186(3):844–9.CrossRefPubMed
39.
go back to reference Burks FN, Liu AB, Suh RS, et al. Understanding the use of immediate intravesical chemotherapy for patients with bladder cancer. J Urol. 2012;188(6):2108–13.CrossRefPubMed Burks FN, Liu AB, Suh RS, et al. Understanding the use of immediate intravesical chemotherapy for patients with bladder cancer. J Urol. 2012;188(6):2108–13.CrossRefPubMed
40.
go back to reference Barocas DA, Liu A, Burks FN, et al. Practice based collaboration to improve the use of immediate intravesical therapy after resection of nonmuscle invasive bladder cancer. J Urol. 2013;190(6):2011–16.CrossRefPubMed Barocas DA, Liu A, Burks FN, et al. Practice based collaboration to improve the use of immediate intravesical therapy after resection of nonmuscle invasive bladder cancer. J Urol. 2013;190(6):2011–16.CrossRefPubMed
41.
go back to reference Loo RK, Lieberman SF, Slezak JM, et al. Stratifying risk of urinary tract malignant tumors in patients with asymptomatic microscopic hematuria. Mayo Clin Proc. 2013;88(2):129–38.CrossRefPubMed Loo RK, Lieberman SF, Slezak JM, et al. Stratifying risk of urinary tract malignant tumors in patients with asymptomatic microscopic hematuria. Mayo Clin Proc. 2013;88(2):129–38.CrossRefPubMed
42.
go back to reference Lillie-Blanton M, Brodie M, Rowland D, Altman D, McIntosh M. Race, ethnicity, and the health care system: public perceptions and experiences. Med Care Res Rev. 2000;57(Suppl 1):218–35.CrossRefPubMed Lillie-Blanton M, Brodie M, Rowland D, Altman D, McIntosh M. Race, ethnicity, and the health care system: public perceptions and experiences. Med Care Res Rev. 2000;57(Suppl 1):218–35.CrossRefPubMed
43.
Metadata
Title
Gender, Race, and Variation in the Evaluation of Microscopic Hematuria Among Medicare Beneficiaries
Authors
Jeffrey C. Bassett, MD, MPH
JoAnn Alvarez, MA
Tatsuki Koyama, PhD
Matthew Resnick, MD
Chaochen You, MD
Shenghua Ni, PhD
David F. Penson, MD, MPH
Daniel A. Barocas, MD, MPH
Publication date
01-04-2015
Publisher
Springer US
Published in
Journal of General Internal Medicine / Issue 4/2015
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-014-3116-2

Other articles of this Issue 4/2015

Journal of General Internal Medicine 4/2015 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.