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Journal of Gastrointestinal Surgery

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01-04-2011 | Original Article

Prognostic Value of Cirrhosis for Intrahepatic Cholangiocarcinoma After Surgical Treatment

Authors: Ya-yong Li, Hao Li, Pin Lv, Gang Liu, Xiao-rong Li, Bu-ning Tian, Dao-jin Chen

Published in: Journal of Gastrointestinal Surgery | Issue 4/2011

Abstract

Background

The surgical outcome and prognostic factors of intrahepatic cholangiocarcinoma are not fully understood. This study aimed to establish the clinical significance of cirrhosis for prognosis in patients with intrahepatic cholangiocarcinoma after surgery.

Methods

One hundred fifteen patients with intrahepatic cholangiocarcinoma who underwent surgical resection between December 2001 and January 2008 were retrospectively analyzed. The prognostic significance of clinicopathologic factors including cirrhosis was assessed by univariate and multivariate analyses.

Results

Thirty-two of the 115 patients (28%) had liver cirrhosis. Complete tumor removal (R0 resection) was performed in 42 patients (75%). Overall median survival time was 21 months, with 1-, 3-, and 5-year actuarial survival rates of 68%, 27%, and 17%, respectively. There was a significant difference in survival between patients with cirrhosis and those without cirrhosis (P = 0.027). Univariate analysis showed that cirrhosis, vascular invasion, hepatic duct invasion, lymph node metastasis, positive surgical margin (R1), and TNM stage were significantly associated with poor survival. Multivariate analysis showed that cirrhosis, positive surgical margin, and lymph node metastases were related to survival, with hazard ratios of 2.49, 3.53, and 4.16, respectively.

Conclusions

Cirrhosis is an independent factor for poor prognosis in intrahepatic cholangiocarcinoma after surgery.

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Title: Prognostic Value of Cirrhosis for Intrahepatic Cholangiocarcinoma After Surgical Treatment
Authors: Ya-yong Li
Hao Li
Pin Lv
Gang Liu
Xiao-rong Li
Bu-ning Tian
Dao-jin Chen
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 4/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1419-8

At a glance: The STEP trials

Springer Medicine

Prognostic Value of Cirrhosis for Intrahepatic Cholangiocarcinoma After Surgical Treatment

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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