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BMC Cancer
Published in: BMC Cancer 1/2002

Open Access 01-12-2002 | Research article

Worldwide trends in mortality from biliary tract malignancies

Author: Tushar Patel

Published in: BMC Cancer | Issue 1/2002

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Abstract

Background

Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown. Although there is a marked global variation in prevalence, some recent studies have suggested an increase in mortality from intrahepatic cholangiocarcinoma in several regions of low endemicity. As the study of mortality trends may yield clues to possible etiological factors, we analyzed worldwide time trends in mortality from biliary tract malignancies.

Methods

Annual age-standardized rates for individual countries were compiled for deaths from biliary tract malignancies using the WHO database. These data were used to analyze gender and site-specific trends in mortality rates.

Results

An increasing trend for mortality from intrahepatic cholangiocarcinoma was noted in most countries. The average estimated annual percentage change (EAPC) in mortality rates for males was 6.9 ± 1.5, and for females was 5.1 ± 1.0. Increased mortality rates were observed in all geographic regions. Within Europe, increases were higher in Western Europe than in Central or Northern Europe. In contrast, mortality rates for extrahepatic biliary tract malignancies showed a decreasing trend in most countries, with an overall average EAPC of -0.3 ± 0.4 for males, but -1.3 ± 0.4 for females.

Conclusions

There has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies.
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Literature
1.
de Groen PC, Gores GJ, LaRusso NF, Gunderson LL, Nagorney DM: Biliary tract cancers. N. Engl. J. Med. 1999, 341: 1368-78. 10.1056/NEJM199910283411807.CrossRefPubMed
2.
Green A, Uttaravichien T, Bhudhisawasdi V, Chartbanchachai W, Elkins DB, Marieng EO, et al: Cholangiocarcinoma in north east Thailand. A hospital-based study. Trop. Geogr. Med. 1991, 43: 193-8.PubMed
3.
Haswell-Elkins MR, Mairiang E, Mairiang P, Chaiyakum J, Chamadol N, Loapaiboon V, et al: Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand. Int. J. Cancer. 1994, 59: 505-9.CrossRefPubMed
4.
Flavell DJ: Liver-fluke infection as an aetiological factor in bile-duct carcinoma of man. Trans. R. Soc. Trop. Med. Hyg. 1981, 75: 814-24.CrossRefPubMed
5.
Parkin DM, Ohshima H, Srivatanakul P, Vatanasapt V: Cholangiocarcinoma: epidemiology, mechanisms of carcinogenesis and prevention. Cancer Epidemiol. Biomarkers Prev. 1993, 2: 537-44.PubMed
6.
Patel T: Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology. 2001, 33: 1353-7. 10.1053/jhep.2001.25087.CrossRefPubMed
7.
Taylor-Robinson SD, Toledano MB, Arora S, Keegan TJ, Hargreaves S, Beck A, et al: Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968–1998. Gut. 2001, 48: 816-20. 10.1136/gut.48.6.816.CrossRefPubMedPubMedCentral
8.
Hsing AW, Gao YT, Devesa SS, Jin F, Fraumeni JF: Rising incidence of biliary tract cancers in Shanghai, China. Int. J. Cancer. 1998, 75: 368-70. 10.1002/(SICI)1097-0215(19980130)75:3<368::AID-IJC7>3.0.CO;2-0.CrossRefPubMed
9.
Kaczynski J, Hansson G, Wallerstedt S: Incidence, etiologic aspects and clinicopathologic features in intrahepatic cholangiocellular carcinoma – a study of 51 cases from a low-endemicity area. Acta Oncol. 1998, 37: 77-83. 10.1080/028418698423212.CrossRefPubMed
10.
11.
Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg L, Edwards BK: SEER Cancer Statistics Review, 1973–1997. Bethesda, MD, National Cancer Institute. 2000
12.
Lazaridis KA, Wiesner RH, Porayko MK, Ludwig J, LaRusso NF: Primary Sclerosing Cholangitis. In: Schiff's Diseases of the Liver. Edited by: Schiff ER, Sorrell M, Maddrey WA. 1999, Philadelphia: Lippincott-Raven, 649-69. 8
13.
Kobayashi M, Ikeda K, Saitoh S, Suzuki F, Tsubota A, Suzuki Y, et al: Incidence of primary cholangiocellular carcinoma of the liver in japanese patients with hepatitis C virus-related cirrhosis. Cancer. 2000, 88: 2471-7. 10.1002/1097-0142(20000601)88:11<2471::AID-CNCR7>3.3.CO;2-K.CrossRefPubMed
14.
Strom BL, Hibberd PL, Soper KA, Stolley PD, Nelson WL: International variations in epidemiology of cancers of the extrahepatic biliary tract. Cancer Res. 1985, 45: 5165-8.PubMed
Metadata
Title
Worldwide trends in mortality from biliary tract malignancies
Author
Tushar Patel
Publication date
01-12-2002
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2002
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-2-10

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