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01-01-2010 | Original Article

Airway Infection Predisposes to Peristomal Infection after Percutaneous Endoscopic Gastrostomy with High Concordance Between Sputum and Wound Isolates

Authors: Chiao-Hsiung Chuang, Kuei-Hsiang Hung, Jen-Ru Chen, Chiung-Yu Chen, Ai-Wen Kao, Wei-Lun Chang, Jiunn-Jong Wu, Bor-Shyang Sheu

Published in: Journal of Gastrointestinal Surgery | Issue 1/2010

Abstract

Background

Peristomal infection is common after percutaneous endoscopic gastrostomy. This study aims to evaluate the correlation between airway and peristomal infected pathogens.

Methods

Before the procedure, sputum cultures were prospectively performed for the patients with airway symptoms. All the patients received prophylactic antibiotics. Once peristomal infection occurred, the wound cultures were obtained to analyze the antibiotic susceptibilities of the pathogens. The paired isolates, with concordance between sputum and wound cultures, were validated for their clone identity using pulsed-field gel electrophoresis.

Results

One hundred twelve patients were enrolled, and 30 patients had peristomal infection. The 31 patients with airway pathogens had a 10-fold higher risk of peristomal infection than the other 81 without airway pathogens (95% CI, 3.85–26.4, p < 0.001). Among patients collected with paired isolates from wound and sputum, 85% had concordant microorganism species. In the paired concordant isolates, 94% had indistinguishable antibiogram, and nearly 90% were clonally identical in pulsed-field gel electrophoresis.

Conclusions

Patients with airway infection have an increased risk of peristomal infection after percutaneous endoscopic gastrostomy. Concerning the high concordance between infected wound and sputum isolates of such patients, the selection of appropriate prophylactic antibiotics could be individual to cover the microorganisms isolated from sputum.

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Title: Airway Infection Predisposes to Peristomal Infection after Percutaneous Endoscopic Gastrostomy with High Concordance Between Sputum and Wound Isolates
Authors: Chiao-Hsiung Chuang
Kuei-Hsiang Hung
Jen-Ru Chen
Chiung-Yu Chen
Ai-Wen Kao
Wei-Lun Chang
Jiunn-Jong Wu
Bor-Shyang Sheu
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 1/2010
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-009-1058-5

At a glance: The STEP trials

Springer Medicine

Airway Infection Predisposes to Peristomal Infection after Percutaneous Endoscopic Gastrostomy with High Concordance Between Sputum and Wound Isolates

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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