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Journal of Gastrointestinal Surgery

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01-01-2010 | Original Article

Tumor Relapse after Pancreatic Cancer Resection is Detected Earlier by 18-FDG PET than by CT

Authors: Cosimo Sperti, Claudio Pasquali, Sergio Bissoli, Franca Chierichetti, Guido Liessi, Sergio Pedrazzoli

Published in: Journal of Gastrointestinal Surgery | Issue 1/2010

Abstract

Introduction

Pancreatic cancer recurrence is often difficult to detect by conventional imaging. Our aim was to evaluate the impact of fluorodeoxyglucose-positron emission tomography (FDG-PET) in the diagnosis of recurrent pancreatic cancer.

Methods

One-hundred thirty-eight patients were followed after resection for pancreatic cancer. Sixty-six underwent only CT and were excluded. Seventy-two patients also had FDG-PET. Recurrent patients were divided in two groups: group-1, CT positive and group 2, CT non diagnostic, FDG-PET positive. Characteristics and survival curves of the two groups were compared. Significance was set at p < 0.05.

Results

Overall, tumors recurred in 63 of 72 (87.5%) patients; two patients had a second cancer resected, thanks to FDG-PET. Tumor relapse was detected by CT in 35 patients and by FDG-PET in 61. Prognostic factors were similar in groups 1 and 2. Five out of 35 group 1 patients underwent surgery (two R0, two bypass, and one exploratory). Ten out of 28 group 2 patients underwent surgery (four R0, two R2, two bypass, and two exploratory). FDG-PET influenced treatment strategies in 32 of 72 patients (44.4%). Group 2 patients survived longer (P = 0.09), but the difference was not significant. Disease-free survival was similar in groups 1 and 2.

Conclusion

Tumor relapse is detected earlier by FDG-PET than by CT. FDG-PET can help select the best candidates for surgical exploration, although the real benefit is still to be defined. It influences treatment strategies in a significant percentage of patients. An earlier diagnosis did not influence survival due to the lack of effective therapies.

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Title: Tumor Relapse after Pancreatic Cancer Resection is Detected Earlier by 18-FDG PET than by CT
Authors: Cosimo Sperti
Claudio Pasquali
Sergio Bissoli
Franca Chierichetti
Guido Liessi
Sergio Pedrazzoli
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 1/2010
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-009-1010-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tumor Relapse after Pancreatic Cancer Resection is Detected Earlier by 18-FDG PET than by CT

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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