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01-05-2020 | Coronavirus | Special Report

Ultra-high-resolution computed tomography can demonstrate alveolar collapse in novel coronavirus (COVID-19) pneumonia

Authors: Tae Iwasawa, Midori Sato, Takafumi Yamaya, Yozo Sato, Yoshinori Uchida, Hideya Kitamura, Eri Hagiwara, Shigeru Komatsu, Daisuke Utsunomiya, Takashi Ogura

Published in: Japanese Journal of Radiology | Issue 5/2020

Abstract

Purpose

To review the chest computed tomography (CT) findings on the ultra-high-resolution CT (U-HRCT) in patients with the Novel coronavirus disease 2019 (COVID-19).

Materials and Methods

In February 2020, six consecutive patients with COVID-19 pneumonia (median age, 69 years) underwent U-HR CT imaging. U-HR-CT has a larger matrix size of 1024 × 1024 thinner slice thickness of 0.25 mm and can demonstrate terminal bronchioles in the normal lungs; as a result, Reid’s secondary lobules and their abnormalities can be identified. The distribution and hallmarks (ground-glass opacity, consolidation with or without architectural distortion, linear opacity, crazy paving) of the lung opacities on U-HRCT were visually evaluated on a 1 K monitor by two experienced reviewers. The CT lung volume was measured, and the ratio of the measured lung volume to the predicted total lung capacity (predTLC) based on sex, age and height was calculated.

Results

All cases showed crazy paving pattern in U-HRCT. In these lesions, the secondary lobules were smaller than those in the un-affected lungs. CT lung volume decreased in two cases comparing predTLC.

Conclusion

U-HRCT can evaluate not only the distribution and hallmarks of COVID-19 pneumonia but also visualize local lung volume loss.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet. 2020;395:497–506. https://doi.org/10.1016/s0140-6736(20)30183-5.CrossRefPubMed

Coronavirus disease 2019 (COVID-19) Situation Report—37 Data as reported by 10 AM CET 3 March 2020. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200303-sitrep-43-covid-19.pdf?sfvrsn=2c21c09c_2. Accessed 3 Mar 2020.

Lei J, Li J, Li X, Qi X. CT imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia. Radiology. 2020;295(1):18. https://doi.org/10.1148/radiol.2020200236.CrossRefPubMed

Chung M, Bernheim A, Mei X, Zhang N, Huang M, Zeng X, et al. CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology. 2020;295(1):202–7. https://doi.org/10.1148/radiol.2020200230.CrossRefPubMed

Pan F, Ye T, Sun P, Gui S, Liang B, Li L, et al. Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia. Radiology. 2020; https://doi.org/10.1148/radiol.2020200370.CrossRefPubMedPubMedCentral

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan China. JAMA. 2020. https://doi.org/10.1001/jama.2020.1585.CrossRefPubMedPubMedCentral

Wu J, Wu X, Zeng W, Guo D, Fang Z, Chen L, et al. Chest CT findings in patients with corona virus disease 2019 and its relationship with clinical features. Invest Radiol. 2020. https://doi.org/10.1097/RLI.0000000000000670.CrossRefPubMedPubMedCentral

Yanagawa M, Hata A, Honda O, Kikuchi N, Miyata T, Uranish A, et al. Subjective and objective comparisons of image quality between ultra-high-resolution CT and conventional area detector CT in phantoms and cadaveric human lungs. Eur Radiol. 2018;28:5060–8. https://doi.org/10.1007/s00330-018-5491-2.CrossRefPubMedPubMedCentral

Albarello F, Pianura E, Di Stefano F, Cristofaro M, Petrone A, Marchioni L, et al. 2019-novel coronavirus severe adult respiratory distress syndrome in two cases in Italy: an uncommon radiological presentation. Int J Infect Dis. 2020. https://doi.org/10.1016/j.ijid.2020.02.043.CrossRefPubMedPubMedCentral

10.

Sahetya SK, Goligher EC, Brower RG. Fifty Years of research in ARDS. Setting positive end-expiratory pressure in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2017;195(11):1429–38. https://doi.org/10.1164/rccm.201610-2035CI.CrossRefPubMedPubMedCentral

11.

Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, et al. Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009;302(17):1872–9. https://doi.org/10.1001/jama.2009.1496.CrossRefPubMed

12.

Luyt CE, Combes A, Trouillet JL, Nieszkowska A, Chastre J. Virus-induced acute respiratory distress syndrome: epidemiology, management and outcome. Presse Med. 2011;40:e561–e568568. https://doi.org/10.1016/j.lpm.2011.05.027.CrossRefPubMedPubMedCentral

13.

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020. https://doi.org/10.1016/S2213-2600(20)30076-X.CrossRefPubMedPubMedCentral

14.

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020. https://doi.org/10.1056/NEJMoa2002032.CrossRefPubMedPubMedCentral

15.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13. https://doi.org/10.1016/s0140-6736(20)30211-7.CrossRefPubMedPubMedCentral

16.

Robbie H, Wells AU, Jacob J, Walsh SLF, Nair A, Srikanthan A, et al. Visual and automated CT measurements of lung volume loss in idiopathic pulmonary fibrosis. AJR Am J Roentgenol. 2019;213(2):318–24. https://doi.org/10.2214/AJR.18.20884.CrossRefPubMed

Title: Ultra-high-resolution computed tomography can demonstrate alveolar collapse in novel coronavirus (COVID-19) pneumonia
Authors: Tae Iwasawa
Midori Sato
Takafumi Yamaya
Yozo Sato
Yoshinori Uchida
Hideya Kitamura
Eri Hagiwara
Shigeru Komatsu
Daisuke Utsunomiya
Takashi Ogura
Publication date: 01-05-2020
Publisher: Springer Singapore
Keywords: Coronavirus
Computed Tomography
Computed Tomography
Pneumonia
COVID-19
Acute Respiratory Distress-Syndrome
Published in: Japanese Journal of Radiology / Issue 5/2020
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-020-00956-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Ultra-high-resolution computed tomography can demonstrate alveolar collapse in novel coronavirus (COVID-19) pneumonia

Abstract

Purpose

Materials and Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Materials and Methods

Results

Conclusion

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