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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 12/2016

01-12-2016 | Original Article

Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in ischemia-causing coronary stenosis: a meta-analysis

Authors: Aimin Ding, Guoqing Qiu, Wensheng Lin, Ling Hu, Guangliang Lu, Xiang Long, Xin Hong, Yaohua Chen, Xiaoping Luo, Qinqin Tang, Dongqin Deng

Published in: Japanese Journal of Radiology | Issue 12/2016

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Abstract

Purpose

Fractional flow reserve based on coronary computed tomographic angiography (CCTA; FFRCT) can evaluate functional severity in coronary artery disease (CAD). This study investigated the diagnostic value of FFRCT for determining CAD severity.

Materials and methods

Medline, Cochrane, EMBASE, and Google Scholar databases were searched until June 16, 2016 using the following search terms: fractional flow reserve, coronary computed tomography angiography, myocardial ischemia. Randomized controlled trials, two-arm prospective studies, and retrospective studies were included in the analysis.

Results

Twenty-one studies were included with a total of 2216 subjects and 2798 vessels. FFRCT, sensitivity per-vessel and per-patient were ≥82% and specificity was ≥73% for diagnosis of ischemia. FFRCT had better diagnostic accuracy and discrimination than CCTA.

Conclusion

This study indicates that FFRCT may be a good tool for screening and diagnosing of myocardial ischemia in patients with CAD.
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Metadata
Title
Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in ischemia-causing coronary stenosis: a meta-analysis
Authors
Aimin Ding
Guoqing Qiu
Wensheng Lin
Ling Hu
Guangliang Lu
Xiang Long
Xin Hong
Yaohua Chen
Xiaoping Luo
Qinqin Tang
Dongqin Deng
Publication date
01-12-2016
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 12/2016
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-016-0589-4

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