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Forensic Toxicology
Published in: Forensic Toxicology 2/2011

01-07-2011 | Original Article

Imaging of methamphetamine incorporated into hair by MALDI-TOF mass spectrometry

Authors: Akihiro Miki, Munehiro Katagi, Noriaki Shima, Hiroe Kamata, Michiaki Tatsuno, Toyofumi Nakanishi, Hitoshi Tsuchihashi, Takayuki Takubo, Koichi Suzuki

Published in: Forensic Toxicology | Issue 2/2011

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Abstract

Matrix-assisted laser desorption ionization (MALDI)–time-of-flight (TOF) mass spectrometry (MS) was used for visual demonstration of methamphetamine (MA) incorporation into human hair. Longitudinal sections of human scalp hair shafts from chronic MA users were directly subjected to imaging MS. Numerous MA-positive spots with various intensities were observed in the specimens, which probably reflect habitual MA abuse and the different MA blood levels upon each administration. This imaging MS method for drugs in hair seems to give much more accurate chronological information on drug use, and clearer discrimination between deliberate drug use and passive exposure, using only a single hair shaft. This is the first report of imaging MS applied to forensic toxicology. This method is expected open a new field in analyses of drugs in hair.
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Metadata
Title
Imaging of methamphetamine incorporated into hair by MALDI-TOF mass spectrometry
Authors
Akihiro Miki
Munehiro Katagi
Noriaki Shima
Hiroe Kamata
Michiaki Tatsuno
Toyofumi Nakanishi
Hitoshi Tsuchihashi
Takayuki Takubo
Koichi Suzuki
Publication date
01-07-2011
Publisher
Springer Japan
Published in
Forensic Toxicology / Issue 2/2011
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-011-0109-2

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