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01-01-2019 | Original Paper

Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii

Authors: Dongsheng Fan, Ting Li, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Zhi-Hong Jiang, Li-Ping Bai

Published in: Journal of Natural Medicines | Issue 1/2019

Abstract

Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A–I (1–9), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7.5, 18.0, 9.0, and 18.2 %, respectively.

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Title: Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii
Authors: Dongsheng Fan
Ting Li
Zhiyuan Zheng
Guo-Yuan Zhu
Xiaojun Yao
Zhi-Hong Jiang
Li-Ping Bai
Publication date: 01-01-2019
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1232-8

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Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii

Abstract

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Abstract

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