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Sleep and Breathing

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29-06-2021 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Breathing irregularities before sleep onset on polysomnography in patients with heart diseases

Authors: Soshi Okamoto, Masaki Ishii, Shinichiro Hibi, Masahiro Akishita, Yasuhiro Yamaguchi

Published in: Sleep and Breathing | Issue 2/2022

Abstract

Purpose

Severe cardiac dysfunction can manifest with diurnal breathing irregularity. However, it remains to be clarified whether or not diurnal breathing irregularity is observed in patients with heart diseases, including relatively mild chronic heart failure (CHF), compared to those without heart diseases.

Methods

In this cross-sectional study, consecutive inpatients who were admitted for evaluation of sleep-disordered breathing were enrolled. We extracted 3.5 min of stable respiratory signals before sleep onset using polysomnography, analyzed the airflow data using fast Fourier transform, and quantified breathing irregularities using Shannon entropy S.

Results

A total of 162 subjects were evaluated. Among these, 39 subjects had heart diseases, including ischemic heart disease (IHD), atrial fibrillation (Af), CHF, and a history of aortic dissection. The values of Shannon entropy S of airflow signals in subjects with heart diseases were significantly higher than in those without heart diseases (p < 0.001). After excluding CHF, the Shannon entropy S was also significantly higher in subjects with heart diseases than in those without heart diseases (p < 0.001). The values of Shannon entropy S were significantly correlated with plasma brain natriuretic peptide levels (r = 0.443, p < 0.001). Although the values were also significantly correlated with body mass index, the presence of heart diseases was independently associated with breathing irregularity in the multiple logistic analysis. Matching analysis revealed consistent differences between subjects with heart diseases and without heart diseases.

Conclusion

Breathing irregularity was observed before sleep onset in subjects with heart diseases who underwent polysomnography to diagnose sleep-disordered breathing.

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Title: Breathing irregularities before sleep onset on polysomnography in patients with heart diseases
Authors: Soshi Okamoto
Masaki Ishii
Shinichiro Hibi
Masahiro Akishita
Yasuhiro Yamaguchi
Publication date: 29-06-2021
Publisher: Springer International Publishing
Keywords: Sleep Apnea
Atrial Fibrillation
Polysomnography
Chronic Heart Failure
Published in: Sleep and Breathing / Issue 2/2022
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02403-2

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