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01-12-2021 | Epilepsy | Basic Science • Original Article

Automatic wavelet-based assessment of behavioral sleep using multichannel electrocorticography in rats

Authors: Anastasiya Runnova, Maksim Zhuravlev, Anton Kiselev, Rodion Ukolov, Kirill Smirnov, Anatoly Karavaev, Evgenia Sitnikova

Published in: Sleep and Breathing | Issue 4/2021

Abstract

Purpose

During the last decade, the reported prevalence of sleep-disordered breathing in adults has been rapidly increasing. Therefore, automatic methods of sleep assessment are of particular interest. In a framework of translational neuroscience, this study introduces a reliable automatic detection system of behavioral sleep in laboratory rats based on the signal recorded at the cortical surface without requiring electromyography.

Methods

Experimental data were obtained in 16 adult male WAG/Rij rats at the age of 9 months. Electrocorticographic signals (ECoG) were recorded in freely moving rats during the entire day (22.5 ± 2.2 h). Automatic wavelet-based assessment of behavioral sleep (BS) was proposed. The performance of this wavelet-based method was validated in a group of rats with genetic predisposition to absence epilepsy (n=16) based on visual analysis of their behavior in simultaneously recorded video.

Results

The accuracy of automatic sleep detection was 98% over a 24-h period. An automatic BS assessment method can be adjusted for detecting short arousals during sleep (microarousals) with various duration.

Conclusions

These findings suggest that automatic wavelet-based assessment of behavioral sleep can be used for assessment of sleep quality. Current analysis indicates a temporal relationship between microarousals, sleep, and epileptic discharges in genetically prone subjects.

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Title: Automatic wavelet-based assessment of behavioral sleep using multichannel electrocorticography in rats
Authors: Anastasiya Runnova
Maksim Zhuravlev
Anton Kiselev
Rodion Ukolov
Kirill Smirnov
Anatoly Karavaev
Evgenia Sitnikova
Publication date: 01-12-2021
Publisher: Springer International Publishing
Keyword: Epilepsy
Published in: Sleep and Breathing / Issue 4/2021
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02357-5

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Automatic wavelet-based assessment of behavioral sleep using multichannel electrocorticography in rats

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

Methods

Results

Conclusions

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