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01-06-2021 | Sickle Cell Anemia | Neurology • Original Article

Evaluation of sleep quality and restless legs syndrome in adult patients with sickle cell anemia

Authors: Nazan Şimşek Erdem, Ramazan Erdem, Gönül Oktay, Erdal Kurtoğlu

Published in: Sleep and Breathing | Issue 2/2021

Abstract

Purpose

To determine the prevalence of poor sleep quality and RLS in adult patients with sickle cell anemia (SCA). The second aim was to identify the risk factors for RLS and impairment of sleep quality in SCA patients.

Materials and methods

Patients at least 18 years old, with hemoglobin electrophoresis confirmation of sickle cell disease, were included. Restless legs syndrome was diagnosed according to the International Restless Legs Syndrome Study Group criteria. The sleep quality of the patients was determined using the Pittsburgh Sleep Quality Index (PSQI) scale. The Epworth Sleepiness Scale (ESS) was used to assess excessive daytime sleepiness.

Results

Of 72 patients enrolled in the study, the median total PSQI score was 5 (R 1–17). The total PSQI score was significantly associated with increased age and number of acute severe or extremely severe painful crises during the previous year (p < 0.001, r = 0.45; p = 0.013, r = 0.291 respectively). Of 72 patients, 13 (18%) had RLS and 11 (15%) had excessive daytime sleepiness. The presence of RLS was significantly associated with increased age (p = 0.004). The presence of RLS was not associated with fetal hemoglobin, hemoglobin, hematocrit, or ferritin levels (p > 0.05 for all).

Conclusion

The prevalence of RLS among this sample of adult patients with sickle cell anemia was much higher than that previously reported for the general Turkish population. The presence of RLS was an important cause of sleep disturbance in these adult patients with SCA.

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Title: Evaluation of sleep quality and restless legs syndrome in adult patients with sickle cell anemia
Authors: Nazan Şimşek Erdem
Ramazan Erdem
Gönül Oktay
Erdal Kurtoğlu
Publication date: 01-06-2021
Publisher: Springer International Publishing
Keywords: Sickle Cell Anemia
Restless Legs Syndrome
Published in: Sleep and Breathing / Issue 2/2021
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-020-02185-z

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Evaluation of sleep quality and restless legs syndrome in adult patients with sickle cell anemia

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