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01-12-2020 | Multiple Sleep Latency Test | Neurology • Original Article

The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study

Authors: Mona S. Aldosari, Awad H. Olaish, Samar Z. Nashwan, Mahmoud M. A. Abulmeaty, Ahmed S. BaHammam

Published in: Sleep and Breathing | Issue 4/2020

Abstract

Purpose

The effects of caffeine on drowsiness and reaction time in patients with narcolepsy are unclear. We aimed to assess the effects of caffeine as add-on therapy in narcolepsy patients.

Methods

A randomized, double-blind, placebo-control clinical pilot trial was conducted with a parallel, two-arm trial allocation ratio of 1:1. Participants attended two study visits 7 days apart. The drug was administered orally in a single opaque capsule containing 200 mg caffeine/placebo daily in the morning for 1 week. Sleepiness was assessed objectively using infrared reflectance oculography to measure the percentage of long eye closure (LEC%) and subjectively using two sleepiness scales, the Stanford Sleepiness Scale (SSS) and Karolinska Sleepiness Scale (KSS). Parameters were measured at baseline (BL) prior to taking the drug, after taking the first dose (FD), and after 1 week (WD) of daily caffeine.

Results

Sixteen participants with narcolepsy were included. No significant differences between groups in baseline measurements were observed. LEC% was significantly decreased after the FD and WD compared with baseline levels (BL 1.4 ± 2.1 vs. FD 0.06 ± 0.0.6 and WD 0.03 ± 0.04). Significant improvements in alertness were observed using the KSS when comparing BL with FD and WD (6.3 ± 1.6, 4.9 ± 1.7, and 4.7 ± 1.7, respectively; p = 0.01). No changes in reaction time or SSS scores were noted.

Conclusion

Our findings suggest that a small dose of caffeine has positive effects on alertness in patients with narcolepsy. However, larger trials are required to confirm these findings.

Trial registration no.

ClinicalTrial.gov NCT02832336

Available only for authorised users

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Title: The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study
Authors: Mona S. Aldosari
Awad H. Olaish
Samar Z. Nashwan
Mahmoud M. A. Abulmeaty
Ahmed S. BaHammam
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Multiple Sleep Latency Test
Narcolepsy
Published in: Sleep and Breathing / Issue 4/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-020-02065-6

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The effects of caffeine on drowsiness in patients with narcolepsy: a double-blind randomized controlled pilot study

Abstract

Purpose

Methods

Results

Conclusion

Trial registration no.

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Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Trial registration no.

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