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Sleep and Breathing
Published in: Sleep and Breathing 4/2020

01-12-2020 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Review

Obstructive sleep apnea and cardiovascular disease, a story of confounders!

Authors: Jacob Collen, Christopher Lettieri, Emerson Wickwire, Aaron Holley

Published in: Sleep and Breathing | Issue 4/2020

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Abstract

Obstructive sleep apnea (OSA) syndrome is increasingly common among middle aged and older adults and is frequently linked to most cardiovascular diseases (CVD). Sleep-disordered breathing and CVD share a number of common risk factors and comorbid conditions including obesity, male gender, advancing age, metabolic syndrome, and hypertension. OSA appears to be associated with worsened CVD outcomes, sleep-related symptoms, quality of life, and risk of motor vehicle accidents. Demonstrating a cause-and-effect relationship between CVD and OSA has been challenging due to shared comorbidities. Strong evidence demonstrating clinically significant benefit for OSA treatments on OSA-related CVD outcomes are limited. In this review, we evaluate potential pathophysiologic mechanisms that link OSA to CVD and focus on specific treatments for OSA, including positive airway pressure (PAP), dental devices, and surgeries with regard to OSA-related CVD outcomes.
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Metadata
Title
Obstructive sleep apnea and cardiovascular disease, a story of confounders!
Authors
Jacob Collen
Christopher Lettieri
Emerson Wickwire
Aaron Holley
Publication date
01-12-2020
Publisher
Springer International Publishing
Published in
Sleep and Breathing / Issue 4/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-019-01945-w

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