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01-08-2020 | Erectile Dysfunction | Urology - Original Paper

The association between gut microbiome and erectile dysfunction: a community-based cross-sectional study in Japan

Authors: Teppei Okamoto, Shingo Hatakeyama, Atsushi Imai, Hayato Yamamoto, Tohru Yoneyama, Kazuyuki Mori, Takahiro Yoneyama, Yasuhiro Hashimoto, Shigeyuki Nakaji, Chikara Ohyama

Published in: International Urology and Nephrology | Issue 8/2020

Abstract

Purpose

We investigated the gut microbiome in subjects with erectile dysfunction (ED) in a community-based population.

Methods

This cross-sectional study surveyed comprehensive health status in 408 men who participated in the Iwaki Health Promotion Project in 2015 in Hirosaki, Japan. The gut microbiome was assessed by tag sequencing of the 16S rRNA gene, which we extracted from fecal samples. Erectile function was evaluated with the five-item International Index of Erectile Function (IIEF-5), and the men were divided into two groups: low-IIEF-5 (≤ 16) and high-IIEF-5 (> 16). Of those, we selected age-adjusted 192 men (96 each) for analysis. We investigated the association of gut microbiome with IIEF-5 between the two groups.

Results

Median age was 50 years. No significant difference was seen in the history of hypertension, DM, CKD, and CVD between the low-IIEF-5 and high-IIEF-5 groups. However, the relative abundance of Alistipes (related with anti-inflammation) and Clostoridium XVIII (related with bowel movement) was significantly different between the two groups. Multivariate logistic analysis demonstrated that the relative abundance of Clostridium XVIII (OR, 2.06; 95% CI, 1.20–3.55, P = 0.009) and Alistipes (OR, 0.81; 95% CI, 0.66–0.99, P = 0.040) and, with an IPSS ≥ 8, were independent factors for low IIEF-5.

Conclusion

We observed significant association between the low-IIEF-5 and high-IIEF-5 groups in Alistipes and Clostoridium XVIII. Further study is necessary to access the causal relationship between the gut microbiome and ED.

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Title: The association between gut microbiome and erectile dysfunction: a community-based cross-sectional study in Japan
Authors: Teppei Okamoto
Shingo Hatakeyama
Atsushi Imai
Hayato Yamamoto
Tohru Yoneyama
Kazuyuki Mori
Takahiro Yoneyama
Yasuhiro Hashimoto
Shigeyuki Nakaji
Chikara Ohyama
Publication date: 01-08-2020
Publisher: Springer Netherlands
Keywords: Erectile Dysfunction
Clostridium
Diabetes
Chronic Kidney Disease
Published in: International Urology and Nephrology / Issue 8/2020
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-020-02443-9

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The association between gut microbiome and erectile dysfunction: a community-based cross-sectional study in Japan

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Purpose

Methods

Results

Conclusion

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