Top

International Urology and Nephrology

Published in:

01-12-2014 | Urology - Original Paper

Associations of carotid artery plaque with lower urinary tract symptoms and erectile dysfunction

Authors: Jun Ho Lee, Soon Ki Kim, Dong-Gi Lee

Published in: International Urology and Nephrology | Issue 12/2014

Abstract

Purpose

To evaluate the relationship of carotid artery plaque with international prostate symptom score (IPSS) and international index of erectile function-5 (IIEF).

Methods

We enrolled 799 men who had participated in a health examination. They received an IPSS, IIEF, a carotid duplex ultrasound, and a full metabolic work-up. Data were analyzed using Spearman’s correlation test, the Mantel–Haenszel Extension test, and logistic regression analyses.

Results

The median age of the study population was 57 years, and the median IPSS and IIEF were 11 and 15, respectively. The IPSS voiding sub-score was significantly correlated with maximum intima-media thickness (max IMT) (P = 0.002). We observed a significant increase in the severity of the voiding sub-score with increasing severity of plaque size (P = 0.003). Additionally, there was an increased likelihood of having a higher IPSS voiding sub-score as severity of plaque size increased after adjusting for age and components of metabolic syndrome. The IIEF showed a significant negative correlation with max IMT (P < 0.001). Additionally, there was a significant increase in the severity of erectile dysfunction (ED) with increased plaque size (P < 0.001). There was a greater likelihood of having moderate ED in the moderate and severe plaque size groups than in the group with an absence of plaque, after adjusting for age and components of metabolic syndrome (odds ratio = 1.672, P = 0.021).

Conclusion

Our data suggest that atherosclerosis may play a role in the development of lower urinary tract symptoms (LUTS) and ED and indicate a potential role of ED and LUTS in the prediction of carotid artery plaque.

Kamycheva E, Johnsen SH, Wilsgaard T, Jorde R, Mathiesen EB (2013) Evaluation of serum 25-hydroxyvitamin d as a predictor of carotid intima-media thickness and carotid total plaque area in nonsmokers: the tromso study. Int J Endocrinol 2013:305141. doi:10.1155/2013/305141 PubMedCentralPubMedCrossRef

Zhao H, Zhao X, Liu X, Cao Y, Hippe DS, Sun J, Li F, Xu J, Yuan C (2013) Association of carotid atherosclerotic plaque features with acute ischemic stroke: a magnetic resonance imaging study. Eur J Radiol 82(9):e465–e470. doi:10.1016/j.ejrad.2013.04.014 PubMedCentralPubMedCrossRef

Mathiesen EB, Johnsen SH, Wilsgaard T, Bonaa KH, Lochen ML, Njolstad I (2011) Carotid plaque area and intima-media thickness in prediction of first-ever ischemic stroke: a 10-year follow-up of 6584 men and women: the Tromso study. Stroke J Cereb Circ 42(4):972–978. doi:10.1161/STROKEAHA.110.589754 CrossRef

Hunt KJ, Evans GW, Folsom AR, Sharrett AR, Chambless LE, Tegeler CH, Heiss G (2001) Acoustic shadowing on B-mode ultrasound of the carotid artery predicts ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. Stroke J Cereb Circ 32(5):1120–1126CrossRef

Krause KJ (2004) Screening potential elderly preferred markers: exploratory analysis of Cardiovascular Health Study (CHS) data. J Insur Med 36(3):194–199PubMed

van der Meer IM, Bots ML, Hofman A, del Sol AI, van der Kuip DA, Witteman JC (2004) Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study. Circulation 109(9):1089–1094. doi:10.1161/01.CIR.0000120708.59903.1B PubMedCrossRef

Engstrom G, Melander O, Hedblad B (2009) Carotid intima-media thickness, systemic inflammation, and incidence of heart failure hospitalizations. Arterioscler Thromb Vasc Biol 29(10):1691–1695. doi:10.1161/ATVBAHA.109.193490 PubMedCrossRef

Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M (2006) Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke J Cereb Circul 37(1):87–92. doi:10.1161/01.STR.0000196964.24024.ea CrossRef

Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, van Kerrebroeck P, Wein A, Wein A, Standardisation Sub-committee of the International Continence S (2002) The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21(2):167–178PubMedCrossRef

10.

NIH Consensus Conference (1993) Impotence. NIH consensus development panel on impotence. JAMA 270(1):83–90

11.

Madersbacher S, Alivizatos G, Nordling J, Sanz CR, Emberton M, de la Rosette JJ (2004) EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines). Eur Urol 46(5):547–554. doi:10.1016/j.eururo.2004.07.016 PubMedCrossRef

12.

Barry MJ (2001) Evaluation of symptoms and quality of life in men with benign prostatic hyperplasia. Urology 58(6 Suppl 1):25–32 (discussion 32) PubMedCrossRef

13.

Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 151(1):54–61PubMed

14.

Lee JH, Kwon H, Park YW (2013) Association of lower urinary tract symptom/benign prostatic hyperplasia measures with international index of erectile function 5 in middle-aged policemen of Korea and the role of metabolic syndrome and testosterone in their relationship. Urology 82(5):1008–1012. doi:10.1016/j.urology.2013.07.003 PubMedCrossRef

15.

Hirano M, Nakamura T, Kitta Y, Sano K, Kodama Y, Kobayashi T, Fujioka D, Saito Y, Yano T, Watanabe K, Watanabe Y, Kawabata K, Obata JE, Kugiyama K (2010) Assessment of carotid plaque echolucency in addition to plaque size increases the predictive value of carotid ultrasound for coronary events in patients with coronary artery disease and mild carotid atherosclerosis. Atherosclerosis 211(2):451–455. doi:10.1016/j.atherosclerosis.2010.03.003 PubMedCrossRef

16.

Togay-Isikay C, Kim J, Betterman K, Andrews C, Meads D, Tesh P, Tegeler C, Oztuna D (2005) Carotid artery tortuosity, kinking, coiling: stroke risk factor, marker, or curiosity? Acta Neurol Belg 105(2):68–72PubMed

17.

Bradley WG (2004) Neurology in clinical practice: principles of diagnosis and management, vol 1. Butterworth-Heinemann Medical, Philadelphia

18.

Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112(17):2735–2752. doi:10.1161/CIRCULATIONAHA.105.169404 PubMedCrossRef

19.

Lee H, Jeong SJ (2014) Epidemiology of lower urinary tract symptoms: emphasis on the status in Korea. Korean J Urol 55(5):300–308. doi:10.4111/kju.2014.55.5.300 PubMedCentralPubMedCrossRef

20.

Coyne KS, Sexton CC, Thompson CL, Milsom I, Irwin D, Kopp ZS, Chapple CR, Kaplan S, Tubaro A, Aiyer LP, Wein AJ (2009) The prevalence of lower urinary tract symptoms (LUTS) in the USA, the UK and Sweden: results from the Epidemiology of LUTS (EpiLUTS) study. BJU Int 104(3):352–360. doi:10.1111/j.1464-410X.2009.08427.x PubMedCrossRef

21.

Lindau ST, Schumm LP, Laumann EO, Levinson W, O’Muircheartaigh CA, Waite LJ (2007) A study of sexuality and health among older adults in the United States. N Engl J Med 357(8):762–774. doi:10.1056/NEJMoa067423 PubMedCentralPubMedCrossRef

22.

Azab S (2013) The impact of atherosclerosis on lower urinary tract function. Aging Male Off J Int Soc Study Aging Male 16(3):108–111. doi:10.3109/13685538.2013.795532 CrossRef

23.

Takahashi N, Shishido K, Sato Y, Ogawa S, Oguro T, Kataoka M, Shiomi H, Uchida H, Haga N, Hosoi T (2012) The association between severity of atherosclerosis and lower urinary tract function in male patients with lower urinary tract symptoms. LUTS 4(1):9–13

24.

Freitas SR, Pereira AC, Floriano MS, Mill JG, Krieger JE (2008) Association of alpha1a-adrenergic receptor polymorphism and blood pressure phenotypes in the Brazilian population. BMC Cardiovasc Disord 8:40. doi:10.1186/1471-2261-8-40 PubMedCentralPubMedCrossRef

25.

Rudner XL, Berkowitz DE, Booth JV, Funk BL, Cozart KL, D’Amico EB, El-Moalem H, Page SO, Richardson CD, Winters B, Marucci L, Schwinn DA (1999) Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age. Circulation 100(23):2336–2343PubMedCrossRef

26.

Finn AV, Kolodgie FD, Virmani R (2010) Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathology. Arterioscler Thromb Vasc Biol 30(2):177–181. doi:10.1161/ATVBAHA.108.173609 PubMedCrossRef

27.

Cetinel B, Onal B (2013) Rationale for the use of anticholinergic agents in overactive bladder with regard to central nervous system and cardiovascular system side effects. Korean J Urol 54(12):806–815. doi:10.4111/kju.2013.54.12.806 PubMedCentralPubMedCrossRef

28.

Shimizu S, Tsounapi P, Shimizu T, Honda M, Inoue K, Dimitriadis F, Saito M (2014) Lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction: Are these conditions related to vascular dysfunction? Int J Urol Off J Jpn Urol Assoc. doi:10.1111/iju.12501

29.

Gokkaya CS, Aktas BK, Toprak U, Yahsi S, Bulut S, Ozden C, Memis A (2012) Is there a concordance between carotid and penile cavernosal artery intima-media thickness in patients with erectile dysfunction? Int J Impot Res 24(1):44–48. doi:10.1038/ijir.2011.46 PubMedCrossRef

30.

Javaroni V, Queiroz-Miguez M, Abreu-Casanova M, Oigman W, Neves MF (2011) Brachial flow-mediated dilation correlates with vardenafil response in hypertensive men with vasculogenic erectile dysfunction. Urology 78(2):368–374. doi:10.1016/j.urology.2011.02.070 PubMedCrossRef

31.

Javaroni V, Queiroz Miguez M, Burla A, Oigman W, Neves MF (2012) Response to on-demand vardenafil was improved by its daily usage in hypertensive men. Urology 80(4):858–864. doi:10.1016/j.urology.2012.06.042 PubMedCrossRef

32.

Irie Y, Katakami N, Kaneto H, Kasami R, Sumitsuji S, Yamasaki K, Tachibana K, Kuroda T, Sakamoto K, Umayahara Y, Ueda Y, Kosugi K, Shimomura I (2012) Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without history of coronary artery disease. Atherosclerosis 221(2):438–444. doi:10.1016/j.atherosclerosis.2012.01.022 PubMedCrossRef

33.

Fujihara K, Suzuki H, Sato A, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yamada N, Sone H, Shimano H (2013) Carotid artery plaque and LDL-to-HDL cholesterol ratio predict atherosclerotic status in coronary arteries in asymptomatic patients with type 2 diabetes mellitus. J Atheroscler and thrombosis 20(5):452–464CrossRef

34.

Polak JF, Pencina MJ, Pencina KM, O’Donnell CJ, Wolf PA, D’Agostino RB Sr (2011) Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med 365(3):213–221. doi:10.1056/NEJMoa1012592 PubMedCentralPubMedCrossRef

35.

Tarcan T, Azadzoi K, Siroky M, Goldstein I, Krane R (1998) Age-related erectile and voiding dysfunction: the role of arterial insufficiency. Br J Urol 82:26–33PubMedCrossRef

Title: Associations of carotid artery plaque with lower urinary tract symptoms and erectile dysfunction
Authors: Jun Ho Lee
Soon Ki Kim
Dong-Gi Lee
Publication date: 01-12-2014
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 12/2014
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-014-0830-y

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Associations of carotid artery plaque with lower urinary tract symptoms and erectile dysfunction

Abstract

Purpose

Methods

Results

Conclusion

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 12/2014

Septic complications and hospital admissions after transrectal ultrasound-guided prostate biopsy: incidence rates and outcomes in 913 consecutive biopsies

Cytomegalovirus disease in patients with glomerular diseases treated by immunosuppressive treatment

Efficacy of tamsulosin hydrochloride in relieving “double-J ureteral stent-related morbidity”: a randomized placebo controlled clinical study

Will metformin postpone high-fat diet promotion of TRAMP mouse prostate cancer development and progression?

IL2-IL21 gene cluster polymorphism is not associated with allograft function after kidney transplantation

Stress urinary incontinence and visceral adipose index: a new risk parameter

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page