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Published in: Journal of Thrombosis and Thrombolysis 3/2009

01-04-2009

Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years

Authors: Vijayalakshmi Kunadian, Caitlin Harrigan, Cafer Zorkun, Alexandra M. Palmer, Katherine J. Ogando, Leah H. Biller, Erin E. Lord, Scott P. Williams, Michelle E. Lew, Lauren N. Ciaglo, Jacqueline L. Buros, Susan J. Marble, William J. Gibson, C. Michael Gibson

Published in: Journal of Thrombosis and Thrombolysis | Issue 3/2009

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Abstract

Since its introduction, the TIMI frame count method has contributed to the understanding of the pathophysiology of coronary artery disease. In this article, the evolution of the TFC method and its applicability in the assessment of various therapeutic modalities are described.
Literature
1.
go back to reference Gibson CM, Cannon CP, Daley WL, Dodge JT Jr, Alexander B Jr, Marble SJ, McCabe CH, Raymond L, Fortin T, Poole WK, Braunwald E (1996) TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 93:879–888PubMed Gibson CM, Cannon CP, Daley WL, Dodge JT Jr, Alexander B Jr, Marble SJ, McCabe CH, Raymond L, Fortin T, Poole WK, Braunwald E (1996) TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 93:879–888PubMed
2.
go back to reference Gibson CM, Safian RD (1991) Measurement of arterial dimensions: review of visual and quantitative angiographic techniques. J Invasive Cardiol 3:66–74PubMed Gibson CM, Safian RD (1991) Measurement of arterial dimensions: review of visual and quantitative angiographic techniques. J Invasive Cardiol 3:66–74PubMed
3.
go back to reference Gibson CM, Sandor T, Stone PH, Pasternak RC, Rosner B, Sacks FM (1992) Quantitative angiographic and statistical methods to assess serial changes in coronary luminal diameter and implications for atherosclerosis regression trials. Am J Cardiol 69:1286–1290PubMedCrossRef Gibson CM, Sandor T, Stone PH, Pasternak RC, Rosner B, Sacks FM (1992) Quantitative angiographic and statistical methods to assess serial changes in coronary luminal diameter and implications for atherosclerosis regression trials. Am J Cardiol 69:1286–1290PubMedCrossRef
4.
go back to reference The TIMI study group (1985) Thrombolysis in Myocardial Infarction (TIMI) trial. New Engl J Med 312:932–936 The TIMI study group (1985) Thrombolysis in Myocardial Infarction (TIMI) trial. New Engl J Med 312:932–936
5.
go back to reference Ross A, Neuhaus K, Ellis S (1995) Frequent lack of correspondence among core laboratories in assessing TIMI flow grade after reperfusion therapy. Circulation 92(suppl 1):I-345 Ross A, Neuhaus K, Ellis S (1995) Frequent lack of correspondence among core laboratories in assessing TIMI flow grade after reperfusion therapy. Circulation 92(suppl 1):I-345
6.
go back to reference Gibson CM, Ryan KA, Murphy SA, Mesley R, Marble SJ, Giugliano RP, Cannon CP, Antman EM, Braunwald E (1999) Impaired coronary blood flow in nonculprit arteries in the setting of acute myocardial infarction. The TIMI study group. Thrombolysis in myocardial infarction. J Am Coll Cardiol 34:974–982PubMedCrossRef Gibson CM, Ryan KA, Murphy SA, Mesley R, Marble SJ, Giugliano RP, Cannon CP, Antman EM, Braunwald E (1999) Impaired coronary blood flow in nonculprit arteries in the setting of acute myocardial infarction. The TIMI study group. Thrombolysis in myocardial infarction. J Am Coll Cardiol 34:974–982PubMedCrossRef
7.
go back to reference Tanedo J, Kelly R, Marquez M, Burns D, Klein L, Costanzo M, Parrillo J, Hollenberg S (2001) Assessing coronary blood flow dynamics with the TIMI frame count method: comparison with simultaneous intracoronary Doppler and ultrasound. Catheter Cardio Inte 53:459–463CrossRef Tanedo J, Kelly R, Marquez M, Burns D, Klein L, Costanzo M, Parrillo J, Hollenberg S (2001) Assessing coronary blood flow dynamics with the TIMI frame count method: comparison with simultaneous intracoronary Doppler and ultrasound. Catheter Cardio Inte 53:459–463CrossRef
9.
go back to reference Vijayalakshmi K, Ashton V, Wright R, Hall J, Stewart M, Davies A, de Belder M (2004) Corrected TIMI frame count: applicability in modern digital catheter laboratories when different frame acquisition rates are used. Catheter Cardio Inte 63:426–432CrossRef Vijayalakshmi K, Ashton V, Wright R, Hall J, Stewart M, Davies A, de Belder M (2004) Corrected TIMI frame count: applicability in modern digital catheter laboratories when different frame acquisition rates are used. Catheter Cardio Inte 63:426–432CrossRef
10.
go back to reference Al-Mousa EN, Dodge JT Jr, Rizzo M, McLean C, Ryan K, Moynihan J, Kelley M, Marble SJ, Goel M, Daley WL, Gibson CM (1998) Thrombolysis in myocardial infarction frame count in saphenous vein grafts. Am Heart J 135:323–328PubMedCrossRef Al-Mousa EN, Dodge JT Jr, Rizzo M, McLean C, Ryan K, Moynihan J, Kelley M, Marble SJ, Goel M, Daley WL, Gibson CM (1998) Thrombolysis in myocardial infarction frame count in saphenous vein grafts. Am Heart J 135:323–328PubMedCrossRef
11.
go back to reference Abaci A, Oguzhan A, Eryol N, Ergin A (1999) Effect of potential confounding factors on the Thrombolysis in Myocardial Infarction (TIMI) trial frame count and its reproducibility. Circulation 100:2219–2223PubMed Abaci A, Oguzhan A, Eryol N, Ergin A (1999) Effect of potential confounding factors on the Thrombolysis in Myocardial Infarction (TIMI) trial frame count and its reproducibility. Circulation 100:2219–2223PubMed
12.
go back to reference Vijayalakshmi K, Kunadian B, Whittaker VJ, Wright RA, Hall JA, Somasundram U, Stewart MJ, Sutton A, Davies A, de Belder MA (2007) Impact of catheter sizes and intracoronary glyceryl trinitrate on the TIMI frame count when digital angiograms are acquired at lower frame rates during elective angiography and PCI. Acute Card Care 9(4):231–238 Vijayalakshmi K, Kunadian B, Whittaker VJ, Wright RA, Hall JA, Somasundram U, Stewart MJ, Sutton A, Davies A, de Belder MA (2007) Impact of catheter sizes and intracoronary glyceryl trinitrate on the TIMI frame count when digital angiograms are acquired at lower frame rates during elective angiography and PCI. Acute Card Care 9(4):231–238
13.
go back to reference Faile B, Guzzo J, Tate D, Nichols T, Smith S, Dehmer G (2000) Effect of sex, hemodynamics, body size, and other clinical variables on the corrected thrombolysis in myocardial infarction frame count used as an assessment of coronary blood flow. Am Heart J 140:308–314PubMedCrossRef Faile B, Guzzo J, Tate D, Nichols T, Smith S, Dehmer G (2000) Effect of sex, hemodynamics, body size, and other clinical variables on the corrected thrombolysis in myocardial infarction frame count used as an assessment of coronary blood flow. Am Heart J 140:308–314PubMedCrossRef
14.
go back to reference Dodge JT Jr, Rizzo M, Nykiel M, Altmann J, Hobkirk K, Brennan M, Gibson CM (1998) Impact of injection rate on the Thrombolysis in Myocardial Infarction (TIMI) trial frame count. Am J Cardiol 81:1268–1270PubMedCrossRef Dodge JT Jr, Rizzo M, Nykiel M, Altmann J, Hobkirk K, Brennan M, Gibson CM (1998) Impact of injection rate on the Thrombolysis in Myocardial Infarction (TIMI) trial frame count. Am J Cardiol 81:1268–1270PubMedCrossRef
15.
go back to reference Gibson CM, Anshelevich M, Murphy S, Luu L, Hynes C, Kliris J, Kermgard S, Otten MH, Antman EM, Cannon CP, Braunwald E (2000) Impact of injections during diagnostic coronary arteriography on coronary patency in the setting of acute myocardial infarction from the TIMI trials. Thrombolysis in myocardial infarction. Am J Cardiol 86:1378–1379, A5PubMedCrossRef Gibson CM, Anshelevich M, Murphy S, Luu L, Hynes C, Kliris J, Kermgard S, Otten MH, Antman EM, Cannon CP, Braunwald E (2000) Impact of injections during diagnostic coronary arteriography on coronary patency in the setting of acute myocardial infarction from the TIMI trials. Thrombolysis in myocardial infarction. Am J Cardiol 86:1378–1379, A5PubMedCrossRef
16.
go back to reference Gibson CM, Kirtane AJ, Murphy SA, Marble SJ, de Lemos JA, Antman EM, Braunwald E (2001) Impact of contrast agent type (ionic versus nonionic) used for coronary angiography on angiographic, electrocardiographic, and clinical outcomes following thrombolytic administration in acute myocardial infarction. Catheter Cardiovasc Interv 53:6–11PubMedCrossRef Gibson CM, Kirtane AJ, Murphy SA, Marble SJ, de Lemos JA, Antman EM, Braunwald E (2001) Impact of contrast agent type (ionic versus nonionic) used for coronary angiography on angiographic, electrocardiographic, and clinical outcomes following thrombolytic administration in acute myocardial infarction. Catheter Cardiovasc Interv 53:6–11PubMedCrossRef
17.
go back to reference Gould K, Lipscomb K, Hamilton G (1974) Physiologic basis for assessing critical coronary stenosis: instantaneous flow response and regional distribution during coronary hyperaemia as measure of coronary flow reserve. Am J Cardiol 33:87–94PubMedCrossRef Gould K, Lipscomb K, Hamilton G (1974) Physiologic basis for assessing critical coronary stenosis: instantaneous flow response and regional distribution during coronary hyperaemia as measure of coronary flow reserve. Am J Cardiol 33:87–94PubMedCrossRef
18.
go back to reference Doucette J, Corl P, Payne H (1992) Validation of Doppler guide wire for intravascular measurements of coronary artery flow velocity. Circulation 85:1899–1891PubMed Doucette J, Corl P, Payne H (1992) Validation of Doppler guide wire for intravascular measurements of coronary artery flow velocity. Circulation 85:1899–1891PubMed
19.
go back to reference Hartley C (1989) Review of intracoronary Doppler catheters. Int J Cardiac Imag 4:159–168CrossRef Hartley C (1989) Review of intracoronary Doppler catheters. Int J Cardiac Imag 4:159–168CrossRef
20.
go back to reference Manginas AM, Gatzov PM, Chasikidis CM, Voudris VM, Pavlides GM, Cokkinos D (1999) Estimation of coronary flow reserve using the Thrombolysis In Myocardial Infarction (TIMI) frame count method.[report]. Am J Cardiol 83:1562–1565PubMedCrossRef Manginas AM, Gatzov PM, Chasikidis CM, Voudris VM, Pavlides GM, Cokkinos D (1999) Estimation of coronary flow reserve using the Thrombolysis In Myocardial Infarction (TIMI) frame count method.[report]. Am J Cardiol 83:1562–1565PubMedCrossRef
21.
go back to reference Gibson CM, Dodge JT Jr, Goel M, Al-Mousa EN, Rizzo M, McLean C, Ryan K, Sparano A, Marble SJ, Daley WL, Cannon CP, Antman EM (1997) Angioplasty guidewire velocity: a new simple method to calculate absolute coronary blood velocity and flow. Am J Cardiol 80:1536–1539PubMedCrossRef Gibson CM, Dodge JT Jr, Goel M, Al-Mousa EN, Rizzo M, McLean C, Ryan K, Sparano A, Marble SJ, Daley WL, Cannon CP, Antman EM (1997) Angioplasty guidewire velocity: a new simple method to calculate absolute coronary blood velocity and flow. Am J Cardiol 80:1536–1539PubMedCrossRef
22.
go back to reference Wong GC, Frisch D, Murphy SA, Sabatine MS, Pai R, James D, Kraimer N, Katsiyiannis PT, Marble SJ, DiBattiste PM, Demopoulos LA, Gourlay SG, Barron HV, Cannon CP, Gibson CM (2003) Time for contrast material to traverse the epicardial artery and the myocardium in ST-segment elevation acute myocardial infarction versus unstable angina pectoris/non-ST-elevation acute myocardial infarction. Am J Cardiol 91:1163–1167PubMedCrossRef Wong GC, Frisch D, Murphy SA, Sabatine MS, Pai R, James D, Kraimer N, Katsiyiannis PT, Marble SJ, DiBattiste PM, Demopoulos LA, Gourlay SG, Barron HV, Cannon CP, Gibson CM (2003) Time for contrast material to traverse the epicardial artery and the myocardium in ST-segment elevation acute myocardial infarction versus unstable angina pectoris/non-ST-elevation acute myocardial infarction. Am J Cardiol 91:1163–1167PubMedCrossRef
23.
go back to reference Perez de PA, Fernandez-Vazquez F, Cuellas-Ramon JC, Iglesias-Garriz I (2005) Coronary clearance frame count: a new index of microvascular perfusion. J Thromb Thrombolysis 19:97–100CrossRef Perez de PA, Fernandez-Vazquez F, Cuellas-Ramon JC, Iglesias-Garriz I (2005) Coronary clearance frame count: a new index of microvascular perfusion. J Thromb Thrombolysis 19:97–100CrossRef
24.
go back to reference Gibson CM, Murphy SA, Rizzo MJ, Ryan KA, Marble SJ, McCabe CH, Cannon CP, Van de Werf F, Braunwald E (1999) Relationship between TIMI frame count and clinical outcomes after thrombolytic administration. Thrombolysis In Myocardial Infarction (TIMI) study group. Circulation 99:1945–1950PubMed Gibson CM, Murphy SA, Rizzo MJ, Ryan KA, Marble SJ, McCabe CH, Cannon CP, Van de Werf F, Braunwald E (1999) Relationship between TIMI frame count and clinical outcomes after thrombolytic administration. Thrombolysis In Myocardial Infarction (TIMI) study group. Circulation 99:1945–1950PubMed
25.
go back to reference Hamada S, Nishiue T, Nakamura S, Sugiura T, Kamihata H, Miyoshi H, Imuro Y, Iwasaka T (2001) TIMI frame count immediately after primary coronary angioplasty as a predictor of functional recovery in patients with TIMI 3 reperfused acute myocardial infarction. J Am Coll Cardiol 38:666–671PubMedCrossRef Hamada S, Nishiue T, Nakamura S, Sugiura T, Kamihata H, Miyoshi H, Imuro Y, Iwasaka T (2001) TIMI frame count immediately after primary coronary angioplasty as a predictor of functional recovery in patients with TIMI 3 reperfused acute myocardial infarction. J Am Coll Cardiol 38:666–671PubMedCrossRef
26.
go back to reference Gibson CM, Dotani MI, Murphy SA, Marble SJ, Dauterman KW, Michaels AD, Dodge JT Jr (2002) Correlates of coronary blood flow before and after percutaneous coronary intervention and their relationship to angiographic and clinical outcomes in the RESTORE trial. Randomized Efficacy Study of Tirofiban for Outcomes and REstenosis. Am Heart J 144:130–135PubMedCrossRef Gibson CM, Dotani MI, Murphy SA, Marble SJ, Dauterman KW, Michaels AD, Dodge JT Jr (2002) Correlates of coronary blood flow before and after percutaneous coronary intervention and their relationship to angiographic and clinical outcomes in the RESTORE trial. Randomized Efficacy Study of Tirofiban for Outcomes and REstenosis. Am Heart J 144:130–135PubMedCrossRef
27.
go back to reference Vijayalakshmi K, Kunadian B, Whittaker VJ, Williams D, Wright RA, Sutton AG, Hall JA, de Belder MA (2007) The impact of chronically diseased coronary arteries and stenting on the corrected TIMI frame count in elective coronary angiography and percutaneous coronary intervention procedures. Catheter Cardiovasc Interv 70:691–700PubMedCrossRef Vijayalakshmi K, Kunadian B, Whittaker VJ, Williams D, Wright RA, Sutton AG, Hall JA, de Belder MA (2007) The impact of chronically diseased coronary arteries and stenting on the corrected TIMI frame count in elective coronary angiography and percutaneous coronary intervention procedures. Catheter Cardiovasc Interv 70:691–700PubMedCrossRef
28.
go back to reference Stankovic G, Manginas A, Voudris V, Pavlides G, Athanassopoulos G, Ostojic M, Cokkinos D (2000) Prediction of restenosis after coronary angioplasty by use of a new index: TIMI frame count/minimal luminal diameter ratio. Circulation 101:962–968PubMed Stankovic G, Manginas A, Voudris V, Pavlides G, Athanassopoulos G, Ostojic M, Cokkinos D (2000) Prediction of restenosis after coronary angioplasty by use of a new index: TIMI frame count/minimal luminal diameter ratio. Circulation 101:962–968PubMed
29.
go back to reference Sahin M, Basoglu T, Canbaz F, Elcik M, Kosus A (2002) The value of the TIMI frame count method in the diagnosis of coronary no-reflow: a comparison with myocardial perfusion SPECT in patients with acute myocardial infarction. Nucl Med Commun 23:1205–1210PubMedCrossRef Sahin M, Basoglu T, Canbaz F, Elcik M, Kosus A (2002) The value of the TIMI frame count method in the diagnosis of coronary no-reflow: a comparison with myocardial perfusion SPECT in patients with acute myocardial infarction. Nucl Med Commun 23:1205–1210PubMedCrossRef
30.
go back to reference Umman B, Nisanci Y, Sezer M, Umman S, Yilmaz E, Oflaz H, Ozsaruhan O (2002) The relationship between corrected TIMI frame count and myocardial fractional flow reserve. J Invasive Cardiol 14:125–128PubMed Umman B, Nisanci Y, Sezer M, Umman S, Yilmaz E, Oflaz H, Ozsaruhan O (2002) The relationship between corrected TIMI frame count and myocardial fractional flow reserve. J Invasive Cardiol 14:125–128PubMed
31.
go back to reference Lee S, Otsuji Y, Minagoe S, Hamasaki S, Toyonaga K, Obata H, Takumi T, Arimura H, Miyata M, Biro S, Toda H, Tei C (2005) Correlation between distal left anterior descending artery flow velocity by transthoracic Doppler echocardiography and corrected TIMI frame count before mechanical reperfusion in patients with anterior acute myocardial infarction. Circ J 69:1022–1028PubMedCrossRef Lee S, Otsuji Y, Minagoe S, Hamasaki S, Toyonaga K, Obata H, Takumi T, Arimura H, Miyata M, Biro S, Toda H, Tei C (2005) Correlation between distal left anterior descending artery flow velocity by transthoracic Doppler echocardiography and corrected TIMI frame count before mechanical reperfusion in patients with anterior acute myocardial infarction. Circ J 69:1022–1028PubMedCrossRef
32.
go back to reference Mavrogeni SI, Manginas A, Papadakis E, Douskou M, Cokkinos D, Katsiva V, Foussas S, Voudris V, Giakoumelos A, Seimenis I, Baras P, Cokkinos DV (2005) Coronary flow evaluation by TIMI frame count and magnetic resonance flow velocity in patients with coronary artery ectasia. J Cardiovasc Magn Reson 7:545–550PubMedCrossRef Mavrogeni SI, Manginas A, Papadakis E, Douskou M, Cokkinos D, Katsiva V, Foussas S, Voudris V, Giakoumelos A, Seimenis I, Baras P, Cokkinos DV (2005) Coronary flow evaluation by TIMI frame count and magnetic resonance flow velocity in patients with coronary artery ectasia. J Cardiovasc Magn Reson 7:545–550PubMedCrossRef
33.
go back to reference Ozdemir N, Kaymaz C, Kirma C, Akcay M, Yuce M, Turan F, Ozkan M (2003) Intravascular ultrasound correlates of corrected TIMI framecount. Jpn Heart J 44:213–224PubMedCrossRef Ozdemir N, Kaymaz C, Kirma C, Akcay M, Yuce M, Turan F, Ozkan M (2003) Intravascular ultrasound correlates of corrected TIMI framecount. Jpn Heart J 44:213–224PubMedCrossRef
34.
go back to reference Yilmaz R, Demirbag R (2005) P-wave dispersion in patients with stable coronary artery disease and its relationship with severity of the disease. J Electrocardiol 38:279–284PubMedCrossRef Yilmaz R, Demirbag R (2005) P-wave dispersion in patients with stable coronary artery disease and its relationship with severity of the disease. J Electrocardiol 38:279–284PubMedCrossRef
35.
go back to reference Dilaveris PE, Andrikopoulos GK, Metaxas G, Richter DJ, Avgeropoulou CK, Androulakis AM, Gialafos EJ, Michaelides AP, Toutouzas PK, Gialafos JE (1999) Effects of ischemia on P wave dispersion and maximum P wave duration during spontaneous anginal episodes. Pacing Clin Electrophysiol 22:1640–1647PubMedCrossRef Dilaveris PE, Andrikopoulos GK, Metaxas G, Richter DJ, Avgeropoulou CK, Androulakis AM, Gialafos EJ, Michaelides AP, Toutouzas PK, Gialafos JE (1999) Effects of ischemia on P wave dispersion and maximum P wave duration during spontaneous anginal episodes. Pacing Clin Electrophysiol 22:1640–1647PubMedCrossRef
36.
go back to reference Dogan SM, Yildirim N, Gursurer M, Aydin M, Kalaycioglu E, Cam F (2006) P-wave duration and dispersion in patients with coronary slow flow and its relationship with thrombolysis in myocardial infarction frame count. J Electrocardiol 41(1):55–59 Dogan SM, Yildirim N, Gursurer M, Aydin M, Kalaycioglu E, Cam F (2006) P-wave duration and dispersion in patients with coronary slow flow and its relationship with thrombolysis in myocardial infarction frame count. J Electrocardiol 41(1):55–59
37.
go back to reference Lee SG, Cheong JP, Shin JK, Kim JW, Park JH (2002) Persistent ST-segment elevation after primary stenting for acute myocardial infarction: its relation to left ventricular recovery. Clin Cardiol 25:372–377PubMedCrossRef Lee SG, Cheong JP, Shin JK, Kim JW, Park JH (2002) Persistent ST-segment elevation after primary stenting for acute myocardial infarction: its relation to left ventricular recovery. Clin Cardiol 25:372–377PubMedCrossRef
38.
go back to reference Gardner GS, Frisch DR, Murphy SA, Kirtane AJ, Giugliano RP, Antman EM, Braunwald E, Gibson CM (2004) Effect of rescue or adjunctive percutaneous coronary intervention of the culprit artery after fibrinolytic administration on epicardial flow in nonculprit arteries. Am J Cardiol 94:178–181PubMedCrossRef Gardner GS, Frisch DR, Murphy SA, Kirtane AJ, Giugliano RP, Antman EM, Braunwald E, Gibson CM (2004) Effect of rescue or adjunctive percutaneous coronary intervention of the culprit artery after fibrinolytic administration on epicardial flow in nonculprit arteries. Am J Cardiol 94:178–181PubMedCrossRef
39.
go back to reference Gibson CM, Goel M, Murphy SA, Dotani I, Marble SJ, Deckelbaum LI, Dodge JT, King SB III (2000) Global impairment of coronary blood flow in the setting of acute coronary syndromes (a RESTORE substudy). Randomized Efficacy Study of Tirofiban for Outcomes and REstenosis. Am J Cardiol 86:1375–1377, A5PubMedCrossRef Gibson CM, Goel M, Murphy SA, Dotani I, Marble SJ, Deckelbaum LI, Dodge JT, King SB III (2000) Global impairment of coronary blood flow in the setting of acute coronary syndromes (a RESTORE substudy). Randomized Efficacy Study of Tirofiban for Outcomes and REstenosis. Am J Cardiol 86:1375–1377, A5PubMedCrossRef
40.
go back to reference Gibson CM, Chen M, Angeja BG, Murphy SA, Marble SJ, Barron HV, Cannon CP (2002) Precordial ST-segment depression in inferior myocardial infarction is associated with slow flow in the non-culprit left anterior descending artery. J Thromb Thrombolysis 13:9–12PubMedCrossRef Gibson CM, Chen M, Angeja BG, Murphy SA, Marble SJ, Barron HV, Cannon CP (2002) Precordial ST-segment depression in inferior myocardial infarction is associated with slow flow in the non-culprit left anterior descending artery. J Thromb Thrombolysis 13:9–12PubMedCrossRef
41.
go back to reference Murphy SA, Chen C, Gourlay SG, Gibbons RJ, Barron HV, Gibson CM (2003) Impairment of myocardial perfusion in both culprit and nonculprit arteries in acute myocardial infarction: a LIMIT AMI substudy. Am J Cardiol 91:325–328PubMedCrossRef Murphy SA, Chen C, Gourlay SG, Gibbons RJ, Barron HV, Gibson CM (2003) Impairment of myocardial perfusion in both culprit and nonculprit arteries in acute myocardial infarction: a LIMIT AMI substudy. Am J Cardiol 91:325–328PubMedCrossRef
42.
go back to reference Heusch G (1990) Alpha-adrenergic mechanisms in myocardial ischemia. Circulation 81:1–13PubMed Heusch G (1990) Alpha-adrenergic mechanisms in myocardial ischemia. Circulation 81:1–13PubMed
43.
go back to reference Gregorini LM, Marco JM, Kozakova MM, Palombo CM, Anguissola GBM, Marco IM, Bernies MM, Cassagneau BM, Distante AM, Bossi I (1999) Alpha-adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction.[article]. Circulation 99:482–490PubMed Gregorini LM, Marco JM, Kozakova MM, Palombo CM, Anguissola GBM, Marco IM, Bernies MM, Cassagneau BM, Distante AM, Bossi I (1999) Alpha-adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction.[article]. Circulation 99:482–490PubMed
44.
go back to reference Gregorini L, Marco J, Farah B, Bernies M, Palombo C, Kozakova M, Bossi IM, Cassagneau B, Fajadet J, Di MC, Albiero R, Cugno M, Grossi A, Heusch G (2002) Effects of selective alpha1- and alpha2-adrenergic blockade on coronary flow reserve after coronary stenting. Circulation 106:2901–2907PubMedCrossRef Gregorini L, Marco J, Farah B, Bernies M, Palombo C, Kozakova M, Bossi IM, Cassagneau B, Fajadet J, Di MC, Albiero R, Cugno M, Grossi A, Heusch G (2002) Effects of selective alpha1- and alpha2-adrenergic blockade on coronary flow reserve after coronary stenting. Circulation 106:2901–2907PubMedCrossRef
45.
go back to reference Yetkin E, Turhan H, Erbay AR, Aksoy Y, Senen K (2005) Increased thrombolysis in myocardial infarction frame count in patients with myocardial infarction and normal coronary arteriogram: a possible link between slow coronary flow and myocardial infarction. Atherosclerosis 181:193–199PubMedCrossRef Yetkin E, Turhan H, Erbay AR, Aksoy Y, Senen K (2005) Increased thrombolysis in myocardial infarction frame count in patients with myocardial infarction and normal coronary arteriogram: a possible link between slow coronary flow and myocardial infarction. Atherosclerosis 181:193–199PubMedCrossRef
46.
go back to reference Barutcu I, Turkmen M, Sezgin AT, Gullu H, Esen AM, Karakaya O, Saglam M, Basaran Y (2005) Increased thrombolysis in myocardial infarction (TIMI) frame count in patients with aortic stenosis but normal coronary arteries. Heart Vessels 20:108–111PubMedCrossRef Barutcu I, Turkmen M, Sezgin AT, Gullu H, Esen AM, Karakaya O, Saglam M, Basaran Y (2005) Increased thrombolysis in myocardial infarction (TIMI) frame count in patients with aortic stenosis but normal coronary arteries. Heart Vessels 20:108–111PubMedCrossRef
47.
go back to reference Turhan H, Erbay AR, Yasar AS, Bicer A, Sasmaz H, Yetkin E (2004) Impaired coronary blood flow in patients with metabolic syndrome: documented by Thrombolysis in Myocardial Infarction (TIMI) frame count method. Am Heart J 148:789–794PubMedCrossRef Turhan H, Erbay AR, Yasar AS, Bicer A, Sasmaz H, Yetkin E (2004) Impaired coronary blood flow in patients with metabolic syndrome: documented by Thrombolysis in Myocardial Infarction (TIMI) frame count method. Am Heart J 148:789–794PubMedCrossRef
48.
go back to reference Papadakis MC, Manginas A, Cotileas P, Demopoulos V, Voudris V, Pavlides G, Foussas SG, Cokkinos DV (2001) Documentation of slow coronary flow by the TIMI frame count in patients with coronary ectasia. Am J Cardiol 88:1030–1032PubMedCrossRef Papadakis MC, Manginas A, Cotileas P, Demopoulos V, Voudris V, Pavlides G, Foussas SG, Cokkinos DV (2001) Documentation of slow coronary flow by the TIMI frame count in patients with coronary ectasia. Am J Cardiol 88:1030–1032PubMedCrossRef
49.
go back to reference Baris N, Sipahi I, Kapadia SR, Nicholls SJ, Erinc K, Gulel O, Crowe TD, Hobbs R, Yamani MH, Taylor DO, Smedira N, Starling RC, Nissen SE, Tuzcu EM (2007) Coronary angiography for follow-up of heart transplant recipients: insights from TIMI frame count and TIMI myocardial perfusion grade. J Heart Lung Transplant 26:593–597PubMedCrossRef Baris N, Sipahi I, Kapadia SR, Nicholls SJ, Erinc K, Gulel O, Crowe TD, Hobbs R, Yamani MH, Taylor DO, Smedira N, Starling RC, Nissen SE, Tuzcu EM (2007) Coronary angiography for follow-up of heart transplant recipients: insights from TIMI frame count and TIMI myocardial perfusion grade. J Heart Lung Transplant 26:593–597PubMedCrossRef
50.
go back to reference Fang JC, Kinlay S, Wexberg P, Amirzadeh A, Gibson CM, Selwyn AP, Ganz P (2000) Use of the thrombolysis in myocardial infarction frame count for the quantitative assessment of transplant-associated arteriosclerosis. Am J Cardiol 86:890–892PubMedCrossRef Fang JC, Kinlay S, Wexberg P, Amirzadeh A, Gibson CM, Selwyn AP, Ganz P (2000) Use of the thrombolysis in myocardial infarction frame count for the quantitative assessment of transplant-associated arteriosclerosis. Am J Cardiol 86:890–892PubMedCrossRef
51.
go back to reference Kelly RF, Sompalli V, Sattar P, Khankari K (2003) Increased TIMI frame counts in cocaine users: a case for increased microvascular resistance in the absence of epicardial coronary disease or spasm. Clin Cardiol 26:319–322PubMedCrossRef Kelly RF, Sompalli V, Sattar P, Khankari K (2003) Increased TIMI frame counts in cocaine users: a case for increased microvascular resistance in the absence of epicardial coronary disease or spasm. Clin Cardiol 26:319–322PubMedCrossRef
52.
go back to reference Weber JE, Hollander JE, Murphy SA, Braunwald E, Gibson CM (2002) Quantitative comparison of coronary artery flow and myocardial perfusion in patients with acute myocardial infarction in the presence and absence of recent cocaine use. J Thromb Thrombolysis 14:239–245PubMedCrossRef Weber JE, Hollander JE, Murphy SA, Braunwald E, Gibson CM (2002) Quantitative comparison of coronary artery flow and myocardial perfusion in patients with acute myocardial infarction in the presence and absence of recent cocaine use. J Thromb Thrombolysis 14:239–245PubMedCrossRef
53.
go back to reference Erbay AR, Turhan H, Senen K, Yetkin O, Yasar AS, Sezgin AT, Atak R, Cehreli S, Yetkin E (2004) Documentation of slow coronary flow by the thrombolysis in myocardial infarction frame count in habitual smokers with angiographically normal coronary arteries. Heart Vessels 19:271–274PubMedCrossRef Erbay AR, Turhan H, Senen K, Yetkin O, Yasar AS, Sezgin AT, Atak R, Cehreli S, Yetkin E (2004) Documentation of slow coronary flow by the thrombolysis in myocardial infarction frame count in habitual smokers with angiographically normal coronary arteries. Heart Vessels 19:271–274PubMedCrossRef
54.
go back to reference Barutcu I, Sezgin AT, Gullu H, Turkmen M, Esen AM (2007) Assessing coronary blood flow with TIMI frame count method in isolated myocardial bridging. Angiology 58:283–288PubMedCrossRef Barutcu I, Sezgin AT, Gullu H, Turkmen M, Esen AM (2007) Assessing coronary blood flow with TIMI frame count method in isolated myocardial bridging. Angiology 58:283–288PubMedCrossRef
55.
go back to reference Yasar AS, Turhan H, Erbay AR, Karabal O, Bicer A, Sasmaz H, Yetkin E (2005) Assessment of coronary blood flow in hypertrophic cardiomyopathy using thrombolysis in myocardial infarction frame count method. J Invasive Cardiol 17:73–76PubMed Yasar AS, Turhan H, Erbay AR, Karabal O, Bicer A, Sasmaz H, Yetkin E (2005) Assessment of coronary blood flow in hypertrophic cardiomyopathy using thrombolysis in myocardial infarction frame count method. J Invasive Cardiol 17:73–76PubMed
56.
go back to reference Zalewski J, Zmudka K, Musialek P, Zajdel W, Pieniazek P, Kadzielski A, Przewlocki T (2004) Detection of microvascular injury by evaluating epicardial blood flow in early reperfusion following primary angioplasty. Int J Cardiol 96:389–396PubMedCrossRef Zalewski J, Zmudka K, Musialek P, Zajdel W, Pieniazek P, Kadzielski A, Przewlocki T (2004) Detection of microvascular injury by evaluating epicardial blood flow in early reperfusion following primary angioplasty. Int J Cardiol 96:389–396PubMedCrossRef
57.
go back to reference Sun H, Fukumoto Y, Ito A, Shimokawa H, Sunagawa K (2005) Coronary microvascular dysfunction in patients with microvascular angina: analysis by TIMI frame count. J Cardiovasc Pharmacol 46:622–626PubMedCrossRef Sun H, Fukumoto Y, Ito A, Shimokawa H, Sunagawa K (2005) Coronary microvascular dysfunction in patients with microvascular angina: analysis by TIMI frame count. J Cardiovasc Pharmacol 46:622–626PubMedCrossRef
58.
go back to reference Sezgin AT, Sigirci A, Barutcu I, Topal E, Sezgin N, Ozdemir R, Yetkin E, Tandogan I, Kosar F, Ermis N, Yologlu S, Bariskaner E, Cehreli S (2003) Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis 14:155–161PubMedCrossRef Sezgin AT, Sigirci A, Barutcu I, Topal E, Sezgin N, Ozdemir R, Yetkin E, Tandogan I, Kosar F, Ermis N, Yologlu S, Bariskaner E, Cehreli S (2003) Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis 14:155–161PubMedCrossRef
59.
go back to reference Pekdemir H, Cicek D, Camsari A, Akkus MN, Cin VG, Doven O, Parmaksiz HT, Katircibasi MT, Ozcan IT (2004) The relationship between plasma endothelin-1, nitric oxide levels, and heart rate variability in patients with coronary slow flow. Ann Noninvasive Electrocardiol 9:24–33PubMedCrossRef Pekdemir H, Cicek D, Camsari A, Akkus MN, Cin VG, Doven O, Parmaksiz HT, Katircibasi MT, Ozcan IT (2004) The relationship between plasma endothelin-1, nitric oxide levels, and heart rate variability in patients with coronary slow flow. Ann Noninvasive Electrocardiol 9:24–33PubMedCrossRef
60.
go back to reference Turhan H, Saydam GS, Erbay AR, Ayaz S, Yasar AS, Aksoy Y, Basar N, Yetkin E (2006) Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. Int J Cardiol 108:224–230PubMedCrossRef Turhan H, Saydam GS, Erbay AR, Ayaz S, Yasar AS, Aksoy Y, Basar N, Yetkin E (2006) Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. Int J Cardiol 108:224–230PubMedCrossRef
61.
go back to reference Barutcu I, Sezgin AT, Sezgin N, Gullu H, Esen AM, Topal E, Ozdemir R (2005) Elevated plasma homocysteine level in slow coronary flow. Int J Cardiol 101:143–145PubMedCrossRef Barutcu I, Sezgin AT, Sezgin N, Gullu H, Esen AM, Topal E, Ozdemir R (2005) Elevated plasma homocysteine level in slow coronary flow. Int J Cardiol 101:143–145PubMedCrossRef
62.
go back to reference Selcuk MT, Selcuk H, Temizhan A, Maden O, Ulupinar H, Baysal E, Ozeke O, Sasmaz A (2007) Asymmetric dimethylarginine plasma concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary flow. Coron Artery Dis 18:545–551PubMedCrossRef Selcuk MT, Selcuk H, Temizhan A, Maden O, Ulupinar H, Baysal E, Ozeke O, Sasmaz A (2007) Asymmetric dimethylarginine plasma concentrations and L-arginine/asymmetric dimethylarginine ratio in patients with slow coronary flow. Coron Artery Dis 18:545–551PubMedCrossRef
63.
go back to reference Li JJ, Qin XW, Li ZC, Zeng HS, Gao Z, Xu B, Zhang CY, Li J (2007) Increased plasma C-reactive protein and interleukin-6 concentrations in patients with slow coronary flow. Clin Chim Acta 385:43–47PubMedCrossRef Li JJ, Qin XW, Li ZC, Zeng HS, Gao Z, Xu B, Zhang CY, Li J (2007) Increased plasma C-reactive protein and interleukin-6 concentrations in patients with slow coronary flow. Clin Chim Acta 385:43–47PubMedCrossRef
64.
go back to reference Schafer U, Kurz T, Jain D, Hartmann F, Dendorfer A, Tolg R, Raasch W, Dominiak P, Katus H, Richardt G (2002) Impaired coronary flow and left ventricular dysfunction after mechanical recanalization in acute myocardial infarction: role of neurohumoral activation? Basic Res Cardiol 97:399–408PubMedCrossRef Schafer U, Kurz T, Jain D, Hartmann F, Dendorfer A, Tolg R, Raasch W, Dominiak P, Katus H, Richardt G (2002) Impaired coronary flow and left ventricular dysfunction after mechanical recanalization in acute myocardial infarction: role of neurohumoral activation? Basic Res Cardiol 97:399–408PubMedCrossRef
65.
go back to reference Yazici M, Demircan S, Durna K, Sahin M (2007) The role of adrenergic activity in slow coronary flow and its relationship to TIMI frame count. Angiology 58:393–400PubMedCrossRef Yazici M, Demircan S, Durna K, Sahin M (2007) The role of adrenergic activity in slow coronary flow and its relationship to TIMI frame count. Angiology 58:393–400PubMedCrossRef
66.
go back to reference Edep M, Guarneri E, Teirstein P, Brown D (1999) Differences in TIMI frame count following successful reperfusion with stenting or percutaneous transluminal coronary angioplasty for acute myocardial infarction. Am J Cardiol 83:1326–1329PubMedCrossRef Edep M, Guarneri E, Teirstein P, Brown D (1999) Differences in TIMI frame count following successful reperfusion with stenting or percutaneous transluminal coronary angioplasty for acute myocardial infarction. Am J Cardiol 83:1326–1329PubMedCrossRef
67.
go back to reference Ozdemir R, Sezgin AT, Barutcu I, Topal E, Gullu H, Acikgoz N (2006) Comparison of direct stenting versus conventional stent implantation on blood flow in patients with ST-segment elevation myocardial infarction. Angiology 57:453–458PubMedCrossRef Ozdemir R, Sezgin AT, Barutcu I, Topal E, Gullu H, Acikgoz N (2006) Comparison of direct stenting versus conventional stent implantation on blood flow in patients with ST-segment elevation myocardial infarction. Angiology 57:453–458PubMedCrossRef
68.
go back to reference Capozzolo C, Piscione F, De Luca G, Cioppa A, Mazzarotto P, Leosco D, Golino P, Indolfi C, Chiariello M (2001) Direct coronary stenting: effect on coronary blood flow, immediate and late clinical results. Catheter Cardiovasc Interv 53:464–473PubMedCrossRef Capozzolo C, Piscione F, De Luca G, Cioppa A, Mazzarotto P, Leosco D, Golino P, Indolfi C, Chiariello M (2001) Direct coronary stenting: effect on coronary blood flow, immediate and late clinical results. Catheter Cardiovasc Interv 53:464–473PubMedCrossRef
69.
go back to reference Loubeyre C, Morice MC, Lefevre T, Piechaud JF, Louvard Y, Dumas P (2002) A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction. J Am Coll Cardiol 39:15–21PubMedCrossRef Loubeyre C, Morice MC, Lefevre T, Piechaud JF, Louvard Y, Dumas P (2002) A randomized comparison of direct stenting with conventional stent implantation in selected patients with acute myocardial infarction. J Am Coll Cardiol 39:15–21PubMedCrossRef
70.
go back to reference Beran GM, Lang IM, Schreiber WM, Denk SM, Stefenelli TM, Syeda BM, Maurer GM, Glogar DMF, Siostrzonek PM (2002) Intracoronary thrombectomy with the X-Sizer catheter system improves epicardial flow and accelerates ST-segment resolution in patients with acute coronary syndrome: a prospective, randomized, controlled study.[report]. Circulation 105:2355–2360PubMedCrossRef Beran GM, Lang IM, Schreiber WM, Denk SM, Stefenelli TM, Syeda BM, Maurer GM, Glogar DMF, Siostrzonek PM (2002) Intracoronary thrombectomy with the X-Sizer catheter system improves epicardial flow and accelerates ST-segment resolution in patients with acute coronary syndrome: a prospective, randomized, controlled study.[report]. Circulation 105:2355–2360PubMedCrossRef
71.
go back to reference Margheri M, Vittori G, Chechi T, Falchetti E, Cosgrave J, Spaziani G, Ricceri I, Giglioli C, Valente S, Gensini GF (2007) Thrombus aspiration with export catheter in ST elevation myocardial infarction. J Interv Cardiol 20:38–43PubMedCrossRef Margheri M, Vittori G, Chechi T, Falchetti E, Cosgrave J, Spaziani G, Ricceri I, Giglioli C, Valente S, Gensini GF (2007) Thrombus aspiration with export catheter in ST elevation myocardial infarction. J Interv Cardiol 20:38–43PubMedCrossRef
72.
go back to reference Bartorelli AL, Koh TH, Di Pede F, Reimers B, Thuesen L, Amann FW, Fabbiocchi F, Suryapranata H (2006) Distal embolic protection during percutaneous coronary intervention in patients with acute coronary syndromes: the RUBY study. Acute Card Care 8:148–154PubMed Bartorelli AL, Koh TH, Di Pede F, Reimers B, Thuesen L, Amann FW, Fabbiocchi F, Suryapranata H (2006) Distal embolic protection during percutaneous coronary intervention in patients with acute coronary syndromes: the RUBY study. Acute Card Care 8:148–154PubMed
73.
go back to reference Stone G, Webb J, Cox D, Brodie B, Quereshi M, Lalynych A, Turco M, Schultheiss H, Dulas D, Rutherford B, Antoniucci D, Krucoff M, Gibbons R, Jones D, Lansky A, Mehran R, for the Enhanced Myocardial Efficacy, Recovery by Aspiration of Liberated Debris (EMERALD) Investigators (2005) Distal Microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction. JAMA 293:1063–1072 Stone G, Webb J, Cox D, Brodie B, Quereshi M, Lalynych A, Turco M, Schultheiss H, Dulas D, Rutherford B, Antoniucci D, Krucoff M, Gibbons R, Jones D, Lansky A, Mehran R, for the Enhanced Myocardial Efficacy, Recovery by Aspiration of Liberated Debris (EMERALD) Investigators (2005) Distal Microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction. JAMA 293:1063–1072
74.
go back to reference Dudek D, Mielecki W, Legutko J, Chyrchel M, Sorysz D, Bartus S, Rzeszutko L, Dubiel JS (2004) Percutaneous thrombectomy with the RESCUE system in acute myocardial infarction. Kardiol Pol 61:523–533PubMed Dudek D, Mielecki W, Legutko J, Chyrchel M, Sorysz D, Bartus S, Rzeszutko L, Dubiel JS (2004) Percutaneous thrombectomy with the RESCUE system in acute myocardial infarction. Kardiol Pol 61:523–533PubMed
75.
go back to reference Vijayalakshmi K, Kunadian B, Wright RA, Sutton AG, Hall JA, de Belder MA (2006) Successful thrombus extraction with the rescue thrombus management system during acute percutaneous coronary intervention improves flow but does not necessarily restore optimal myocardial tissue perfusion. Catheter Cardiovasc Interv 67:879–886PubMedCrossRef Vijayalakshmi K, Kunadian B, Wright RA, Sutton AG, Hall JA, de Belder MA (2006) Successful thrombus extraction with the rescue thrombus management system during acute percutaneous coronary intervention improves flow but does not necessarily restore optimal myocardial tissue perfusion. Catheter Cardiovasc Interv 67:879–886PubMedCrossRef
76.
go back to reference Limbruno U, Micheli A, De Carlo M, Amoroso G, Rossini R, Palagi C, Di Bello V, Petronio AS, Fontanini G, Mariani M (2003) Mechanical prevention of distal embolization during primary angioplasty: safety, feasibility, and impact on myocardial reperfusion. Circulation 108:171–176PubMedCrossRef Limbruno U, Micheli A, De Carlo M, Amoroso G, Rossini R, Palagi C, Di Bello V, Petronio AS, Fontanini G, Mariani M (2003) Mechanical prevention of distal embolization during primary angioplasty: safety, feasibility, and impact on myocardial reperfusion. Circulation 108:171–176PubMedCrossRef
77.
go back to reference Silva-Orrego P, Colombo P, Bigi R, Gregori D, Delgado A, Salvade P, Oreglia J, Orrico P, de Biase A, Piccalo G, Bossi I, Klugmann S (2006) Thrombus aspiration before primary angioplasty improves myocardial reperfusion in acute myocardial infarction: the DEAR-MI (Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarction) study. J Am Coll Cardiol 48:1552–1559PubMedCrossRef Silva-Orrego P, Colombo P, Bigi R, Gregori D, Delgado A, Salvade P, Oreglia J, Orrico P, de Biase A, Piccalo G, Bossi I, Klugmann S (2006) Thrombus aspiration before primary angioplasty improves myocardial reperfusion in acute myocardial infarction: the DEAR-MI (Dethrombosis to Enhance Acute Reperfusion in Myocardial Infarction) study. J Am Coll Cardiol 48:1552–1559PubMedCrossRef
78.
go back to reference Dorr M, Vogelgesang D, Hummel A, Staudt A, Robinson DM, Felix SB, Dahm JB (2007) Excimer laser thrombus elimination for prevention of distal embolization and no-reflow in patients with acute ST elevation myocardial infarction: results from the randomized LaserAMI study. Int J Cardiol 116:20–26PubMedCrossRef Dorr M, Vogelgesang D, Hummel A, Staudt A, Robinson DM, Felix SB, Dahm JB (2007) Excimer laser thrombus elimination for prevention of distal embolization and no-reflow in patients with acute ST elevation myocardial infarction: results from the randomized LaserAMI study. Int J Cardiol 116:20–26PubMedCrossRef
79.
go back to reference Vijayalakshmi K, Kunadian B, Whittaker VJ, Wright RA, Hall JA, Sutton A, Muir D, de Belder MA (2007) Intra-aortic counterpulsation does not improve coronary flow early after PCI in a high-risk group of patients: observations from a randomized trial to explore its mode of action. J Invasive Cardiol 19:339–346PubMed Vijayalakshmi K, Kunadian B, Whittaker VJ, Wright RA, Hall JA, Sutton A, Muir D, de Belder MA (2007) Intra-aortic counterpulsation does not improve coronary flow early after PCI in a high-risk group of patients: observations from a randomized trial to explore its mode of action. J Invasive Cardiol 19:339–346PubMed
80.
go back to reference Petronio AS, Rovai D, Musumeci G, Baglini R, Nardi C, Limbruno U, Palagi C, Volterrani D, Mariani M (2003) Effects of abciximab on microvascular integrity and left ventricular functional recovery in patients with acute infarction treated by primary coronary angioplasty. Eur Heart J 24:67–76PubMedCrossRef Petronio AS, Rovai D, Musumeci G, Baglini R, Nardi C, Limbruno U, Palagi C, Volterrani D, Mariani M (2003) Effects of abciximab on microvascular integrity and left ventricular functional recovery in patients with acute infarction treated by primary coronary angioplasty. Eur Heart J 24:67–76PubMedCrossRef
81.
go back to reference Gabriel HM, Oliveira JA, da Silva PC, da Costa JM, da Cunha JA (2006) Early administration of abciximab bolus in the emergency department improves angiographic outcome after primary PCI as assessed by TIMI frame count: results of the early ReoPro administration in myocardial infarction (ERAMI) trial. Catheter Cardiovasc Interv 68:218–224PubMedCrossRef Gabriel HM, Oliveira JA, da Silva PC, da Costa JM, da Cunha JA (2006) Early administration of abciximab bolus in the emergency department improves angiographic outcome after primary PCI as assessed by TIMI frame count: results of the early ReoPro administration in myocardial infarction (ERAMI) trial. Catheter Cardiovasc Interv 68:218–224PubMedCrossRef
82.
go back to reference Gibson CM, Morrow DA, Murphy SA, Palabrica TM, Jennings LK, Stone PH, Lui HH, Bulle T, Lakkis N, Kovach R, Cohen DJ, Fish P, McCabe CH, Braunwald E (2006) A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial. J Am Coll Cardiol 47:2364–2373PubMedCrossRef Gibson CM, Morrow DA, Murphy SA, Palabrica TM, Jennings LK, Stone PH, Lui HH, Bulle T, Lakkis N, Kovach R, Cohen DJ, Fish P, McCabe CH, Braunwald E (2006) A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial. J Am Coll Cardiol 47:2364–2373PubMedCrossRef
83.
go back to reference Gibson CM, Cohen DJ, Cohen EA, Lui HK, Murphy SA, Marble SJ, Kitt M, Lorenz T, Tcheng JE (2001) Effect of eptifibatide on coronary flow reserve following coronary stent implantation (an ESPRIT substudy). Enhanced suppression of the platelet IIb/IIIa receptor with integrilin therapy. Am J Cardiol 87:1293–1295PubMedCrossRef Gibson CM, Cohen DJ, Cohen EA, Lui HK, Murphy SA, Marble SJ, Kitt M, Lorenz T, Tcheng JE (2001) Effect of eptifibatide on coronary flow reserve following coronary stent implantation (an ESPRIT substudy). Enhanced suppression of the platelet IIb/IIIa receptor with integrilin therapy. Am J Cardiol 87:1293–1295PubMedCrossRef
84.
go back to reference Romagnoli E, Burzotta F, Trani C, Mazzari MA, Biondi-Zoccai GG, De VM, Giannico F, Niccoli G, Prati F, Rebuzzi AG, Mongiardo R, Crea F (2005) Angiographic evaluation of the effect of intracoronary abciximab administration in patients undergoing urgent PCI. Int J Cardiol 105:250–255PubMedCrossRef Romagnoli E, Burzotta F, Trani C, Mazzari MA, Biondi-Zoccai GG, De VM, Giannico F, Niccoli G, Prati F, Rebuzzi AG, Mongiardo R, Crea F (2005) Angiographic evaluation of the effect of intracoronary abciximab administration in patients undergoing urgent PCI. Int J Cardiol 105:250–255PubMedCrossRef
85.
go back to reference Vijayalakshmi K, Whittaker VJ, Kunadian B, Graham J, Wright RA, Hall JA, Sutton A, de Belder MA (2006) Prospective, randomised, controlled trial to study the effect of intracoronary injection of verapamil and adenosine on coronary blood flow during percutaneous coronary intervention in patients with acute coronary syndromes. Heart 92:1278–1284PubMedCrossRef Vijayalakshmi K, Whittaker VJ, Kunadian B, Graham J, Wright RA, Hall JA, Sutton A, de Belder MA (2006) Prospective, randomised, controlled trial to study the effect of intracoronary injection of verapamil and adenosine on coronary blood flow during percutaneous coronary intervention in patients with acute coronary syndromes. Heart 92:1278–1284PubMedCrossRef
86.
go back to reference Marzilli M, Orsini E, Marraccini P, Testa R (2000) Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation 101:2154–2159PubMed Marzilli M, Orsini E, Marraccini P, Testa R (2000) Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation 101:2154–2159PubMed
87.
go back to reference Michaels AD, Appleby M, Otten MH, Dauterman K, Ports TA, Chou TM, Gibson CM (2002) Pretreatment with intragraft verapamil prior to percutaneous coronary intervention of saphenous vein graft lesions: results of the randomized, controlled vasodilator prevention on no-reflow (VAPOR) trial. J Invasive Cardiol 14:299–302PubMed Michaels AD, Appleby M, Otten MH, Dauterman K, Ports TA, Chou TM, Gibson CM (2002) Pretreatment with intragraft verapamil prior to percutaneous coronary intervention of saphenous vein graft lesions: results of the randomized, controlled vasodilator prevention on no-reflow (VAPOR) trial. J Invasive Cardiol 14:299–302PubMed
88.
go back to reference Beltrame JF, Turner SP, Leslie SL, Solomon P, Freedman SB, Horowitz JD (2004) The angiographic and clinical benefits of mibefradil in the coronary slow flow phenomenon. J Am Coll Cardiol 44:57–62PubMedCrossRef Beltrame JF, Turner SP, Leslie SL, Solomon P, Freedman SB, Horowitz JD (2004) The angiographic and clinical benefits of mibefradil in the coronary slow flow phenomenon. J Am Coll Cardiol 44:57–62PubMedCrossRef
89.
go back to reference Huang RI, Patel P, Walinsky P, Fischman DL, Ogilby JD, Awar M, Frankil C, Savage MP (2006) Efficacy of intracoronary nicardipine in the treatment of no-reflow during percutaneous coronary intervention. Catheter Cardiovasc Interv 68:671–676PubMedCrossRef Huang RI, Patel P, Walinsky P, Fischman DL, Ogilby JD, Awar M, Frankil C, Savage MP (2006) Efficacy of intracoronary nicardipine in the treatment of no-reflow during percutaneous coronary intervention. Catheter Cardiovasc Interv 68:671–676PubMedCrossRef
90.
go back to reference Ishii H, Ichimiya S, Kanashiro M, Amano T, Imai K, Murohara T, Matsubara T (2005) Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction. Circulation 112:1284–1288PubMedCrossRef Ishii H, Ichimiya S, Kanashiro M, Amano T, Imai K, Murohara T, Matsubara T (2005) Impact of a single intravenous administration of nicorandil before reperfusion in patients with ST-segment-elevation myocardial infarction. Circulation 112:1284–1288PubMedCrossRef
91.
go back to reference Lim SY, Bae EH, Jeong MH, Kang DG, Lee YS, Kim KH, Lee SH, Yoon KH, Hong SN, Park HW, Hong YJ, Kim JH, Kim W, Ahn YK, Cho JG, Park JC, Kang JC (2004) Effect of combined intracoronary adenosine and nicorandil on no-reflow phenomenon during percutaneous coronary intervention. Circ J 68:928–932PubMedCrossRef Lim SY, Bae EH, Jeong MH, Kang DG, Lee YS, Kim KH, Lee SH, Yoon KH, Hong SN, Park HW, Hong YJ, Kim JH, Kim W, Ahn YK, Cho JG, Park JC, Kang JC (2004) Effect of combined intracoronary adenosine and nicorandil on no-reflow phenomenon during percutaneous coronary intervention. Circ J 68:928–932PubMedCrossRef
92.
go back to reference Cakmak M, Tanriverdi H, Cakmak N, Evrengul H, Cetemen S, Kuru O (2007) Simvastatin may improve myocardial perfusion abnormality in slow coronary flow. Cardiology 110:39–44PubMedCrossRef Cakmak M, Tanriverdi H, Cakmak N, Evrengul H, Cetemen S, Kuru O (2007) Simvastatin may improve myocardial perfusion abnormality in slow coronary flow. Cardiology 110:39–44PubMedCrossRef
93.
go back to reference Fearon WF, Balsam LB, Farouque HM, Caffarelli AD, Robbins RC, Fitzgerald PJ, Yock PG, Yeung AC (2003) Novel index for invasively assessing the coronary microcirculation. Circulation 107:3129–3132PubMedCrossRef Fearon WF, Balsam LB, Farouque HM, Caffarelli AD, Robbins RC, Fitzgerald PJ, Yock PG, Yeung AC (2003) Novel index for invasively assessing the coronary microcirculation. Circulation 107:3129–3132PubMedCrossRef
94.
go back to reference Aarnoudse W, van den Berg P, van de Vosse F, Geven M, Rutten M, Van Turnhout M, Fearon W, de Bruyne B, Pijls N (2004) Myocardial resistance assessed by guidewire-based pressure-temperature measurement: in vitro validation. Catheter Cardiovasc Interv 62(1):56–63PubMedCrossRef Aarnoudse W, van den Berg P, van de Vosse F, Geven M, Rutten M, Van Turnhout M, Fearon W, de Bruyne B, Pijls N (2004) Myocardial resistance assessed by guidewire-based pressure-temperature measurement: in vitro validation. Catheter Cardiovasc Interv 62(1):56–63PubMedCrossRef
95.
go back to reference Siebes M, Verhoeff BJ, Meuwissen M, de Winter RJ, Spaan JA, Piek JJ (2004) Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions. Circulation 109:756–762PubMedCrossRef Siebes M, Verhoeff BJ, Meuwissen M, de Winter RJ, Spaan JA, Piek JJ (2004) Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions. Circulation 109:756–762PubMedCrossRef
Metadata
Title
Use of the TIMI frame count in the assessment of coronary artery blood flow and microvascular function over the past 15 years
Authors
Vijayalakshmi Kunadian
Caitlin Harrigan
Cafer Zorkun
Alexandra M. Palmer
Katherine J. Ogando
Leah H. Biller
Erin E. Lord
Scott P. Williams
Michelle E. Lew
Lauren N. Ciaglo
Jacqueline L. Buros
Susan J. Marble
William J. Gibson
C. Michael Gibson
Publication date
01-04-2009
Publisher
Springer US
Published in
Journal of Thrombosis and Thrombolysis / Issue 3/2009
Print ISSN: 0929-5305
Electronic ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-008-0220-3

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