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Reviews in Endocrine and Metabolic Disorders
Published in: Reviews in Endocrine and Metabolic Disorders 4/2020

01-12-2020 | Bisphosphonate

Clinical features, diagnosis and treatment of Paget’s disease of bone in mainland China: A systematic review

Authors: Qin-Yi Wang, Shan-Jiang Fu, Na Ding, Shu-Ying Liu, Rong Chen, Zhang-Xin Wen, Sang Fu, Zhi-Feng Sheng, Yang-Na Ou

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 4/2020

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Abstract

Paget’s disease of bone (PDB) is a metabolic bone disease with distinct geographical and ethnic differences in its pathogenesis. In this study, we aimed to retrospectively analyze the clinical features and the status of diagnosis and treatment of PDB in mainland China to improve the clinician’s understanding of this disease. For this purpose, we conducted a systematic review of 118 articles, including a total of 332 patients with PDB. The results showed that the onset age of PDB in mainland China was 46–60 years. The number of male patients in most age groups was slightly higher than that of female patients, but there was no statistical difference (p > 0.05). The gender ratio (male to female) of PDB in mainland China was significantly different from that in Japan (p < 0.05), but not from that in the USA (p > 0.05). The clinical manifestations of PDB patients in mainland China mainly included ostealgia, bone malformation, hearing loss, and fracture, and bisphosphonate was used as the main treatment drug. These findings were similar to those in Japan, UK, and USA. Total alkaline phosphatase (TALP) level was elevated in about 89.7% of patients, and no correlation between TALP level and ostealgia was observed (p > 0.05). In addition, no difference in TALP level between males and females in each group was observed (p > 0.05).
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Metadata
Title
Clinical features, diagnosis and treatment of Paget’s disease of bone in mainland China: A systematic review
Authors
Qin-Yi Wang
Shan-Jiang Fu
Na Ding
Shu-Ying Liu
Rong Chen
Zhang-Xin Wen
Sang Fu
Zhi-Feng Sheng
Yang-Na Ou
Publication date
01-12-2020
Publisher
Springer US
Published in
Reviews in Endocrine and Metabolic Disorders / Issue 4/2020
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-020-09544-x

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