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Reviews in Endocrine and Metabolic Disorders

Published in:

01-12-2018

Innate immune cells in the adipose tissue

Authors: Kyoung-Jin Chung, Marina Nati, Triantafyllos Chavakis, Antonios Chatzigeorgiou

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 4/2018

Abstract

Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT. In the course of obesity, pro-inflammatory immune cells, such as M1-like macrophages, prevail in the AT. Inflammation in the obese AT is associated with the development of metabolic complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Thus, the immune cell-adipocyte crosstalk in the AT is an important regulator of AT function and systemic metabolism. We discuss herein this crosstalk with a special focus on the role of innate immune cells in AT inflammation and metabolic homeostasis in obesity.

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Title: Innate immune cells in the adipose tissue
Authors: Kyoung-Jin Chung
Marina Nati
Triantafyllos Chavakis
Antonios Chatzigeorgiou
Publication date: 01-12-2018
Publisher: Springer US
Published in: Reviews in Endocrine and Metabolic Disorders / Issue 4/2018
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-018-9451-6

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Innate immune cells in the adipose tissue

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