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Reviews in Endocrine and Metabolic Disorders

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Open Access 01-09-2017

Sunshine vitamin and thyroid

Authors: Immacolata Cristina Nettore, Luigi Albano, Paola Ungaro, Annamaria Colao, Paolo Emidio Macchia

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 3/2017

Abstract

Vitamin D exerts its canonical roles on the musculoskeletal system and in the calcium/phosphorus homeostasis. In the last years, increasing evidences suggested several extra-skeletal actions of this hormone, indicating that vitamin D may produce effects in almost all the body tissues. These are mediated by the presence of vitamin D receptor (VDR) and thanks to the presence of the 1-α-hydroxylase, the protein that converts the 25-hydroxyvitamin (calcidiol) to the active form 1,25-dihydroxyvitamin (calcitriol). Several studies evaluated the possible role of vitamin D in the pathogenesis of thyroid diseases, and this review will focus on the available data of the literature evaluating the association between vitamin D and thyroid function, vitamin D and autoimmune thyroid diseases, including Hashimoto’s thyroiditis, Graves’ disease and post-partum thyroiditis, and vitamin D and thyroid cancer.

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Title: Sunshine vitamin and thyroid
Authors: Immacolata Cristina Nettore
Luigi Albano
Paola Ungaro
Annamaria Colao
Paolo Emidio Macchia
Publication date: 01-09-2017
Publisher: Springer US
Published in: Reviews in Endocrine and Metabolic Disorders / Issue 3/2017
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-017-9406-3

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