Skip to main content
Top
Published in: Endocrine 2/2013

01-04-2013 | Meta-Analysis

Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis

Authors: Ming Feng, Hua Li, Su-Fang Chen, Wei-Fang Li, Fang-Bin Zhang

Published in: Endocrine | Issue 2/2013

Login to get access

Abstract

Environmental and genetic factors are thought to be involved in the pathogenesis of autoimmune thyroid diseases (AITD), which include Graves’ disease, Hashimoto’s thyroiditis. Polymorphisms of vitamin D receptor (VDR) were implicated in AITDs risk. To date, many studies have evaluated the association between a functional polymorphism in the VDR gene and AITDs risk; however, the result is still ambiguous and inconclusive. To address the association of VDR gene FokI (rs10735810), TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232) polymorphisms with AITD risk by meta-analysis. By searching the relevant literature, a total of eight studies were identified and meta-analyzed. HWE for each study are checked. Crude odds ratios (OR) with 95 % confidence intervals (CIs) were used to assess the strength of association in the allele polymorphism, codominant model, dominant model, and recessive model. The result indicates that the BsmI or TaqI polymorphisms is significantly associated with AITD risk (OR = 0.801 95 % CI 0.705, 0.910, Pz = 0.001 for B vs. b; OR = 0.854, 95 % CI 0.757, 0.963, Pz = 0.010 for t vs. T), while the ApaI or FokI polymorphism do not. In the subgroup analysis in Europeans, the decreased risk of AITD remained for the B or t variant. This gene-based analysis indicates that, based on current evidence from published studies, the cumulative effect of BsmI or TaqI polymorphisms in VDR is significantly associated with AITD.
Literature
1.
go back to reference L.J. DeGroot, J. Quintans, The causes of autoimmune thyroid disease. Endocr. Rev. 10(4), 537–562 (1989)PubMedCrossRef L.J. DeGroot, J. Quintans, The causes of autoimmune thyroid disease. Endocr. Rev. 10(4), 537–562 (1989)PubMedCrossRef
2.
go back to reference Y. Tomer, T.F. Davies, Infection, thyroid disease, and autoimmunity. Endocr. Rev. 14(1), 107–120 (1993)PubMed Y. Tomer, T.F. Davies, Infection, thyroid disease, and autoimmunity. Endocr. Rev. 14(1), 107–120 (1993)PubMed
3.
go back to reference F. Guarneri, S. Benvenga, Environmental factors and genetic background that interact to cause autoimmune thyroid disease. Curr. Opin. Endocrinol. Diabetes Obes. 14(5), 398–409 (2007)PubMedCrossRef F. Guarneri, S. Benvenga, Environmental factors and genetic background that interact to cause autoimmune thyroid disease. Curr. Opin. Endocrinol. Diabetes Obes. 14(5), 398–409 (2007)PubMedCrossRef
4.
go back to reference J.M. Valdivielso, E. Fernandez, Vitamin D receptor polymorphisms and diseases. Clin. Chim. Acta 371(1), 1–12 (2006)PubMedCrossRef J.M. Valdivielso, E. Fernandez, Vitamin D receptor polymorphisms and diseases. Clin. Chim. Acta 371(1), 1–12 (2006)PubMedCrossRef
5.
go back to reference J.D. Simmons, C. Mullighan, K.I. Welsh, D.P. Jewell, Vitamin D receptor gene polymorphism: association with Crohn’s disease susceptibility. Gut 47(2), 211–214 (2000)PubMedCrossRef J.D. Simmons, C. Mullighan, K.I. Welsh, D.P. Jewell, Vitamin D receptor gene polymorphism: association with Crohn’s disease susceptibility. Gut 47(2), 211–214 (2000)PubMedCrossRef
6.
go back to reference A. Vogel, C.P. Strassburg, M.P. Manns, Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis. Hepatology 35(1), 126–131 (2002)PubMedCrossRef A. Vogel, C.P. Strassburg, M.P. Manns, Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis. Hepatology 35(1), 126–131 (2002)PubMedCrossRef
7.
go back to reference Y.H. Lee, S.C. Bae, S.J. Choi, J.D. Ji, G.G. Song, Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol. Biol. Rep. 38(6), 3643–3651 (2011)PubMedCrossRef Y.H. Lee, S.C. Bae, S.J. Choi, J.D. Ji, G.G. Song, Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol. Biol. Rep. 38(6), 3643–3651 (2011)PubMedCrossRef
8.
go back to reference C.A. Hitchon, Y. Sun, D.B. Robinson, C.A. Peschken, C.N. Bernstein, K.A. Siminovitch, H.S. El-Gabalawy, Vitamin D receptor polymorphism rs2228570 (Fok1) is associated with rheumatoid arthritis in North American natives. J. Rheumatol. 39(9), 1792–1797 (2012)PubMedCrossRef C.A. Hitchon, Y. Sun, D.B. Robinson, C.A. Peschken, C.N. Bernstein, K.A. Siminovitch, H.S. El-Gabalawy, Vitamin D receptor polymorphism rs2228570 (Fok1) is associated with rheumatoid arthritis in North American natives. J. Rheumatol. 39(9), 1792–1797 (2012)PubMedCrossRef
9.
go back to reference A.G. Uitterlinden, Y. Fang, J.B.J. van Meurs, H.A.P. Pols, J.P.T.M. van Leeuwen, Genetics and biology of vitamin D receptor polymorphisms. Gene 338(2), 143–156 (2004)PubMedCrossRef A.G. Uitterlinden, Y. Fang, J.B.J. van Meurs, H.A.P. Pols, J.P.T.M. van Leeuwen, Genetics and biology of vitamin D receptor polymorphisms. Gene 338(2), 143–156 (2004)PubMedCrossRef
10.
go back to reference M. Stefanic, I. Karner, L. Glavas-Obrovac, S. Papic, D. Vrdoljak, G. Levak, B. Krstonosic, Association of vitamin D receptor gene polymorphism with susceptibility to Graves’ disease in Eastern Croatian population: case–control study. Croat. Med. J. 46(4), 639–646 (2005)PubMed M. Stefanic, I. Karner, L. Glavas-Obrovac, S. Papic, D. Vrdoljak, G. Levak, B. Krstonosic, Association of vitamin D receptor gene polymorphism with susceptibility to Graves’ disease in Eastern Croatian population: case–control study. Croat. Med. J. 46(4), 639–646 (2005)PubMed
11.
go back to reference E. Ramos-Lopez, A. Kurylowicz, T. Bednarczuk, J. Paunkovic, C. Seidl, K. Badenhoop, Vitamin D receptor polymorphisms are associated with Graves’ disease in German and Polish but not in Serbian patients. Thyroid 15(10), 1125–1130 (2005)PubMedCrossRef E. Ramos-Lopez, A. Kurylowicz, T. Bednarczuk, J. Paunkovic, C. Seidl, K. Badenhoop, Vitamin D receptor polymorphisms are associated with Graves’ disease in German and Polish but not in Serbian patients. Thyroid 15(10), 1125–1130 (2005)PubMedCrossRef
12.
go back to reference W. Horst-Sikorska, M. Ignaszak-Szczepaniak, M. Marcinkowska, M. Kaczmarek, M. Stajgis, R. Slomski, Association analysis of vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves’ disease. Acta Biochim. Pol. 55(2), 371–380 (2008)PubMed W. Horst-Sikorska, M. Ignaszak-Szczepaniak, M. Marcinkowska, M. Kaczmarek, M. Stajgis, R. Slomski, Association analysis of vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves’ disease. Acta Biochim. Pol. 55(2), 371–380 (2008)PubMed
13.
go back to reference X.J. Huo, F. Wei, J.X. Huo, R.N. Su, Y.X. Xue, J.H. Wei, Association of vitamin D receptor gene BsmI polymorphism with autoimmune thyroid disease in Innermongolia People of the Han Nationality. J. Radioimmunol. 23(1), 72–74 (2010) X.J. Huo, F. Wei, J.X. Huo, R.N. Su, Y.X. Xue, J.H. Wei, Association of vitamin D receptor gene BsmI polymorphism with autoimmune thyroid disease in Innermongolia People of the Han Nationality. J. Radioimmunol. 23(1), 72–74 (2010)
14.
go back to reference A. Maalej, E. Petit-Teixeira, G. Chabchoub, M.B. Hamad, A. Rebai, N.R. Farid, F. Cornelis, H. Ayadi, Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: familial and case/control studies. J. Clin. Immunol. 28(1), 21–25 (2008)PubMedCrossRef A. Maalej, E. Petit-Teixeira, G. Chabchoub, M.B. Hamad, A. Rebai, N.R. Farid, F. Cornelis, H. Ayadi, Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: familial and case/control studies. J. Clin. Immunol. 28(1), 21–25 (2008)PubMedCrossRef
15.
go back to reference M. Stefanic, S. Papic, M. Suver, L. Glavas-Obrovac, I. Karner, Association of vitamin D receptor gene 3′-variants with Hashimoto’s thyroiditis in the Croatian population. Int. J. Immunogenet. 35(2), 125–131 (2008)PubMedCrossRef M. Stefanic, S. Papic, M. Suver, L. Glavas-Obrovac, I. Karner, Association of vitamin D receptor gene 3′-variants with Hashimoto’s thyroiditis in the Croatian population. Int. J. Immunogenet. 35(2), 125–131 (2008)PubMedCrossRef
16.
go back to reference Y. Ban, Y. Ban, M. Taniyama, T. Katagiri, Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves’ disease. Thyroid 10(6), 475–480 (2000)PubMed Y. Ban, Y. Ban, M. Taniyama, T. Katagiri, Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves’ disease. Thyroid 10(6), 475–480 (2000)PubMed
17.
go back to reference W.Y. Lin, L. Wan, C.H. Tsai, R.H. Chen, C.C. Lee, F.J. Tsai, Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto’s thyroiditis in Chinese patients in Taiwan. J. Clin. Lab. Anal. 20(3), 109–112 (2006)PubMedCrossRef W.Y. Lin, L. Wan, C.H. Tsai, R.H. Chen, C.C. Lee, F.J. Tsai, Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto’s thyroiditis in Chinese patients in Taiwan. J. Clin. Lab. Anal. 20(3), 109–112 (2006)PubMedCrossRef
18.
go back to reference D.M. Provvedini, C.D. Tsoukas, L.J. Deftos, S.C. Manolagas, 1, 25-dihydroxyvitamin D3 receptors in human leukocytes. Science 221(4616), 1181–1183 (1983)PubMedCrossRef D.M. Provvedini, C.D. Tsoukas, L.J. Deftos, S.C. Manolagas, 1, 25-dihydroxyvitamin D3 receptors in human leukocytes. Science 221(4616), 1181–1183 (1983)PubMedCrossRef
19.
go back to reference J. Smolders, E. Peelen, M. Thewissen, P. Menheere, J.W. Tervaert, R. Hupperts, J. Damoiseaux, The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmun. Rev. 8(7), 621–626 (2009)PubMedCrossRef J. Smolders, E. Peelen, M. Thewissen, P. Menheere, J.W. Tervaert, R. Hupperts, J. Damoiseaux, The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmun. Rev. 8(7), 621–626 (2009)PubMedCrossRef
20.
go back to reference T. Yasuda, Y. Okamoto, N. Hamada, K. Miyashita, M. Takahara, F. Sakamoto, T. Miyatsuka, T. Kitamura, N. Katakami, D. Kawamori, M. Otsuki, T.A. Matsuoka, H. Kaneto, I. Shimomura, Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves’ disease. Endocrine (2012). doi:10.1007/s12020-012-9679-y T. Yasuda, Y. Okamoto, N. Hamada, K. Miyashita, M. Takahara, F. Sakamoto, T. Miyatsuka, T. Kitamura, N. Katakami, D. Kawamori, M. Otsuki, T.A. Matsuoka, H. Kaneto, I. Shimomura, Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves’ disease. Endocrine (2012). doi:10.​1007/​s12020-012-9679-y
22.
go back to reference T. Yasuda, Y. Okamoto, N. Hamada, K. Miyashita, M. Takahara, F. Sakamoto, T. Miyatsuka, T. Kitamura, N. Katakami, D. Kawamori, M. Otsuki, T.A. Matsuoka, H. Kaneto, I. Shimomura, Serum vitamin D levels are decreased in patients without remission of Graves’ disease. Endocrine (2012). doi:10.1007/s12020-012-9789-6 T. Yasuda, Y. Okamoto, N. Hamada, K. Miyashita, M. Takahara, F. Sakamoto, T. Miyatsuka, T. Kitamura, N. Katakami, D. Kawamori, M. Otsuki, T.A. Matsuoka, H. Kaneto, I. Shimomura, Serum vitamin D levels are decreased in patients without remission of Graves’ disease. Endocrine (2012). doi:10.​1007/​s12020-012-9789-6
23.
go back to reference C.M. Huang, M.C. Wu, J.Y. Wu, F.J. Tsai, Association of vitamin D receptor gene BsmI polymorphisms in Chinese patients with systemic lupus erythematosus. Lupus 11(1), 31–34 (2002)PubMedCrossRef C.M. Huang, M.C. Wu, J.Y. Wu, F.J. Tsai, Association of vitamin D receptor gene BsmI polymorphisms in Chinese patients with systemic lupus erythematosus. Lupus 11(1), 31–34 (2002)PubMedCrossRef
24.
go back to reference V. Skrabic, T. Zemunik, M. Situm, J. Terzic, Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in the Dalmatian population. Diabetes Res. Clin. Pract. 59(1), 31–35 (2003)PubMedCrossRef V. Skrabic, T. Zemunik, M. Situm, J. Terzic, Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in the Dalmatian population. Diabetes Res. Clin. Pract. 59(1), 31–35 (2003)PubMedCrossRef
25.
go back to reference G.K. Whitfield, L.S. Remus, P.W. Jurutka, H. Zitzer, A.K. Oza, H.T. Dang, C.A. Haussler, M.A. Galligan, M.L. Thatcher, C. Encinas Dominguez, M.R. Haussler, Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol. Cell. Endocrinol. 177(1–2), 145–159 (2001)PubMedCrossRef G.K. Whitfield, L.S. Remus, P.W. Jurutka, H. Zitzer, A.K. Oza, H.T. Dang, C.A. Haussler, M.A. Galligan, M.L. Thatcher, C. Encinas Dominguez, M.R. Haussler, Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol. Cell. Endocrinol. 177(1–2), 145–159 (2001)PubMedCrossRef
Metadata
Title
Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis
Authors
Ming Feng
Hua Li
Su-Fang Chen
Wei-Fang Li
Fang-Bin Zhang
Publication date
01-04-2013
Publisher
Springer US
Published in
Endocrine / Issue 2/2013
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-012-9812-y

Other articles of this Issue 2/2013

Endocrine 2/2013 Go to the issue