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Reviews in Endocrine and Metabolic Disorders

Published in:

01-09-2017

Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept

Authors: Barbara Altieri, Giovanna Muscogiuri, Luigi Barrea, Chantal Mathieu, Carla V. Vallone, Luca Mascitelli, Giorgia Bizzaro, Vincenzo M. Altieri, Giacomo Tirabassi, Giancarlo Balercia, Silvia Savastano, Nicola Bizzaro, Cristina L. Ronchi, Annamaria Colao, Alfredo Pontecorvi, Silvia Della Casa

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 3/2017

Abstract

In the last few years, more attention has been given to the “non-calcemic” effect of vitamin D. Several observational studies and meta-analyses demonstrated an association between circulating levels of vitamin D and outcome of many common diseases, including endocrine diseases, chronic diseases, cancer progression, and autoimmune diseases. In particular, cells of the immune system (B cells, T cells, and antigen presenting cells), due to the expression of 1α-hydroxylase (CYP27B1), are able to synthesize the active metabolite of vitamin D, which shows immunomodulatory properties. Moreover, the expression of the vitamin D receptor (VDR) in these cells suggests a local action of vitamin D in the immune response. These findings are supported by the correlation between the polymorphisms of the VDR or the CYP27B1 gene and the pathogenesis of several autoimmune diseases. Currently, the optimal plasma 25-hydroxyvitamin D concentration that is necessary to prevent or treat autoimmune diseases is still under debate. However, experimental studies in humans have suggested beneficial effects of vitamin D supplementation in reducing the severity of disease activity. In this review, we summarize the evidence regarding the role of vitamin D in the pathogenesis of autoimmune endocrine diseases, including type 1 diabetes mellitus, Addison’s disease, Hashimoto’s thyroiditis, Graves’ disease and autoimmune polyendocrine syndromes. Furthermore, we discuss the supplementation with vitamin D to prevent or treat autoimmune diseases.

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Title: Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept
Authors: Barbara Altieri
Giovanna Muscogiuri
Luigi Barrea
Chantal Mathieu
Carla V. Vallone
Luca Mascitelli
Giorgia Bizzaro
Vincenzo M. Altieri
Giacomo Tirabassi
Giancarlo Balercia
Silvia Savastano
Nicola Bizzaro
Cristina L. Ronchi
Annamaria Colao
Alfredo Pontecorvi
Silvia Della Casa
Publication date: 01-09-2017
Publisher: Springer US
Published in: Reviews in Endocrine and Metabolic Disorders / Issue 3/2017
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-016-9405-9

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STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

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