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Published in:

01-06-2009

Transitioning of children with GH deficiency to adult dosing: changes in body composition

Authors: Vi Thuy Nguyen, Madhusmita Misra

Published in: Pituitary | Issue 2/2009

Abstract

As more evidence gathers regarding the beneficial effect of growth hormone replacement therapy (GHRT) on body composition and other parameters in adults with childhood-onset growth hormone deficiency (GHD), questions emerge regarding whether or not GHRT should be discontinued following cessation of statural growth, and the effect of GHRT during the transition period on body composition and related parameters. This review discusses the effect of discontinuation of GHRT following attainment of adult stature, and the treatment and dose effect when GHRT is reinstated. We also review data regarding who should receive GHRT, the criteria for diagnosing persistent GHD, dosing of GHRT and the possibility of a GH ‘holiday’.

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Title: Transitioning of children with GH deficiency to adult dosing: changes in body composition
Authors: Vi Thuy Nguyen
Madhusmita Misra
Publication date: 01-06-2009
Publisher: Springer US
Published in: Pituitary / Issue 2/2009
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-008-0101-y

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