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Published in: International Journal of Clinical Pharmacy 3/2018

01-06-2018 | Research Article

Herbal medicine use among Type 2 diabetes mellitus patients in Nigeria: understanding the magnitude and predictors of use

Authors: Ogochukwu Ukamaka Amaeze, Roseline Iberi Aderemi-Williams, Modupeola Anuoluwapo Ayo-Vaughan, Deborah Aderoju Ogundemuren, Damilola Segun Ogunmola, Emmanuel Nwanolue Anyika

Published in: International Journal of Clinical Pharmacy | Issue 3/2018

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Abstract

Background Patients with chronic diseases exploit complementary and alternative treatment options to manage their conditions better and improve well-being. Objective To determine the prevalence and predictors of herbal medicine use among Type 2 Diabetes patients in Lagos, Nigeria. Setting Secondary healthcare facilities in Lagos state, Nigeria. Method The study design was a cross sectional survey. A two-stage sampling approach was used to select the health facilities and patients were recruited consecutively to attain the sample size. Data was collected using a structured and standardized interviewer-administered questionnaire. Characteristics, prevalence and predictors of herbal medicine use were assessed using descriptive statistics and multivariate regression analyses. Main outcome measure Herbal medicine use among Type 2 diabetes mellitus patients. Results 453 patients were surveyed, 305 (67.3%) reported herbal medicine use, among whom 108 (35.4%) used herbal and conventional medicines concurrently; 206 (67.5%) did not disclose use to their physician. Herbal medicine use was significantly associated with age (p = 0.045), educational level (p = 0.044), occupation (p = 0.013), duration of diabetes disease (p = 0.007), mode of diabetes management (p = 0.02), a positive history of diabetes (p = 0.011) and presence of diabetes complication (p = 0.033). Formulations or whole herbs of Vernonia amygdalina, Moringa oleifera, Ocimum gratissimum, Picralima nitida, and herbal mixtures were the commonest herbal medicine. Beliefs and perceptions about herbal medicine varied between the users and non-users. Conclusion The use of herbal medicine among Type 2 diabetes mellitus patients in Lagos, Nigeria is high. There is dire need for health care practitioners to frequently probe patients for herbal medicine use and be aware of their health behaviour and choices, with a view to manage the disease better.
Literature
3.
go back to reference Alebiosu OC, Familoni OB, Ogunsemi OO, Raimi TH, Balogun WO, Odusan O, et al. Community based diabetes risk assessment in Ogun state, Nigeria (World Diabetes Foundation Project 08-321). Indian J Endocrinol Metab. 2013;17(4):653–8.CrossRefPubMedPubMedCentral Alebiosu OC, Familoni OB, Ogunsemi OO, Raimi TH, Balogun WO, Odusan O, et al. Community based diabetes risk assessment in Ogun state, Nigeria (World Diabetes Foundation Project 08-321). Indian J Endocrinol Metab. 2013;17(4):653–8.CrossRefPubMedPubMedCentral
5.
go back to reference Mbanya JC, Assah FK, Saji J, Atanga EN. Obesity and Type 2 diabetes mellitus in sub-Sahara Africa. Curr Diab Rep. 2014;14:501.CrossRefPubMed Mbanya JC, Assah FK, Saji J, Atanga EN. Obesity and Type 2 diabetes mellitus in sub-Sahara Africa. Curr Diab Rep. 2014;14:501.CrossRefPubMed
6.
go back to reference Idemyor V. Diabetes in sub-Saharan Africa: health care perspectives, challenges and the economic burden of disease. J Natl Med Assoc. 2010;102(7):650–3.CrossRefPubMed Idemyor V. Diabetes in sub-Saharan Africa: health care perspectives, challenges and the economic burden of disease. J Natl Med Assoc. 2010;102(7):650–3.CrossRefPubMed
7.
go back to reference Algothamy AS, Alruqayb WS, Abdallah MA, Mohamed KM, Albarraq AA. Prevalence of using herbal drugs as anti-diabetic agents in Taif Area, Kingdom of Saudi Arabia. Saudi J Health Sci. 2016;3(3):137–40. Algothamy AS, Alruqayb WS, Abdallah MA, Mohamed KM, Albarraq AA. Prevalence of using herbal drugs as anti-diabetic agents in Taif Area, Kingdom of Saudi Arabia. Saudi J Health Sci. 2016;3(3):137–40.
10.
go back to reference Tulunay M, Aypak C, Yikilkan H, Gorpelioglu S. Herbal medicine use among patients with chronic diseases. J Intercult Ethnopharmacol. 2015;4(3):217–20.CrossRefPubMedPubMedCentral Tulunay M, Aypak C, Yikilkan H, Gorpelioglu S. Herbal medicine use among patients with chronic diseases. J Intercult Ethnopharmacol. 2015;4(3):217–20.CrossRefPubMedPubMedCentral
13.
go back to reference Awodele O, Amagon KI, Usman SO, Obasi PC. Safety of herbal medicines use: case study of Ikorodu residents in Lagos, Nigeria. Curr Drug Saf. 2014;9:138–44.CrossRefPubMed Awodele O, Amagon KI, Usman SO, Obasi PC. Safety of herbal medicines use: case study of Ikorodu residents in Lagos, Nigeria. Curr Drug Saf. 2014;9:138–44.CrossRefPubMed
14.
go back to reference Achigbu EO, Achigbu KI. Traditional medication use among out-patients attending the eye clinic of a Secondary health facility in Owerri South-East Nigeria. Orient J Med. 2014;62(3–4):107–13. Achigbu EO, Achigbu KI. Traditional medication use among out-patients attending the eye clinic of a Secondary health facility in Owerri South-East Nigeria. Orient J Med. 2014;62(3–4):107–13.
16.
go back to reference Nwako OS, Fakeye TO. Evaluation of use of herbal medicines among ambulatory hypertensive patients attending a Secondary healthcare facility in Nigeria. Int J Pharm Pract. 2009;17(2):101–5.CrossRef Nwako OS, Fakeye TO. Evaluation of use of herbal medicines among ambulatory hypertensive patients attending a Secondary healthcare facility in Nigeria. Int J Pharm Pract. 2009;17(2):101–5.CrossRef
18.
go back to reference Alami Z, Aynaou H, Alami B, Hdidou Y, Latrech H. Herbal medicines use among diabetic patients in Oriental Morocco. J Pharmacogn Phyther. 2015;7(2):9–17.CrossRef Alami Z, Aynaou H, Alami B, Hdidou Y, Latrech H. Herbal medicines use among diabetic patients in Oriental Morocco. J Pharmacogn Phyther. 2015;7(2):9–17.CrossRef
19.
go back to reference Jegede A, Oladosu P, Ameh S, Kolo I, Izebe K, Builders P, et al. Status of management of diabetes mellitus by traditional medicine practitioners in Nigeria. J Med Plants Res. 2011;5(27):6309–15.CrossRef Jegede A, Oladosu P, Ameh S, Kolo I, Izebe K, Builders P, et al. Status of management of diabetes mellitus by traditional medicine practitioners in Nigeria. J Med Plants Res. 2011;5(27):6309–15.CrossRef
20.
go back to reference Mwangi J, Gitonga L. Perceptions and use of herbal remedies among patients with diabetes mellitus in Murang’a North District, Kenya. Open J Clin Diagn. 2014;4:152–72.CrossRef Mwangi J, Gitonga L. Perceptions and use of herbal remedies among patients with diabetes mellitus in Murang’a North District, Kenya. Open J Clin Diagn. 2014;4:152–72.CrossRef
21.
go back to reference Ogbera A, Dada O, Adeleye F, Jewo P. Complementary and alternative medicine use in diabetes mellitus. West Afr J Med. 2010;29(3):158–61.PubMed Ogbera A, Dada O, Adeleye F, Jewo P. Complementary and alternative medicine use in diabetes mellitus. West Afr J Med. 2010;29(3):158–61.PubMed
22.
go back to reference Quandt SA, Verhoef MJ, Arcury TA, Lewith GT, Steinsbekk A, Kristoffersen AE, et al. Development of an international questionnaire to measure use of complementary and alternative medicine (I-CAM-Q). J Altern Complement Med. 2009;15(4):331–9.CrossRefPubMedPubMedCentral Quandt SA, Verhoef MJ, Arcury TA, Lewith GT, Steinsbekk A, Kristoffersen AE, et al. Development of an international questionnaire to measure use of complementary and alternative medicine (I-CAM-Q). J Altern Complement Med. 2009;15(4):331–9.CrossRefPubMedPubMedCentral
23.
go back to reference Ali BAM, Mohamed MS. Herbal medicine use among patients with Type 2 diabetes in North Sudan. Annu Res Rev Biol. 2014;4(11):1827–38.CrossRef Ali BAM, Mohamed MS. Herbal medicine use among patients with Type 2 diabetes in North Sudan. Annu Res Rev Biol. 2014;4(11):1827–38.CrossRef
24.
go back to reference Al-garni AM, Al-Raddadi RM, Al-Amri TA. Patterns and determinants of complementary and alternative medicine use among Type 2 diabetic patients in a diabetic center in Saudi Arabia. J Fundam Appl Sci. 2017;19(1S):1738–48. Al-garni AM, Al-Raddadi RM, Al-Amri TA. Patterns and determinants of complementary and alternative medicine use among Type 2 diabetic patients in a diabetic center in Saudi Arabia. J Fundam Appl Sci. 2017;19(1S):1738–48.
25.
go back to reference Baldé NM, Youla A, Baldé MD, Kaké A, Diallo MM, Baldé MA, Maugendre D. Herbal medicine and treatment of diabetes in Africa: an example from Guinea. Diabetes Metab. 2006;32(2):171–5.CrossRefPubMed Baldé NM, Youla A, Baldé MD, Kaké A, Diallo MM, Baldé MA, Maugendre D. Herbal medicine and treatment of diabetes in Africa: an example from Guinea. Diabetes Metab. 2006;32(2):171–5.CrossRefPubMed
29.
go back to reference Bell RA, Suerken CK, Grzwacz JG, Lang W, Quandt SA, Arcury TA. Complementary and alternative medicine use among adults with diabetes in the United States. Altern Ther Health Med. 2006;12(5):16–22.PubMed Bell RA, Suerken CK, Grzwacz JG, Lang W, Quandt SA, Arcury TA. Complementary and alternative medicine use among adults with diabetes in the United States. Altern Ther Health Med. 2006;12(5):16–22.PubMed
31.
go back to reference Singh J, Singh R, Gautam CS. Self-medication with herbal remedies amongst patients of type 2 diabetes mellitus: a preliminary study. Indian J Endocrinol Metab. 2012;16(4):662–3.CrossRefPubMedPubMedCentral Singh J, Singh R, Gautam CS. Self-medication with herbal remedies amongst patients of type 2 diabetes mellitus: a preliminary study. Indian J Endocrinol Metab. 2012;16(4):662–3.CrossRefPubMedPubMedCentral
32.
go back to reference Tarirai C, Viljoen AM, Hamman JH. Herb–drug interactions reviewed. Expert Opin Drug Metab Toxicol. 2010;6(12):1515–38.CrossRefPubMed Tarirai C, Viljoen AM, Hamman JH. Herb–drug interactions reviewed. Expert Opin Drug Metab Toxicol. 2010;6(12):1515–38.CrossRefPubMed
33.
go back to reference Izzo AA. Interactions between herbs and conventional drugs: overview of the clinical data. Med Princ Pract. 2012;21(5):404–28.CrossRefPubMed Izzo AA. Interactions between herbs and conventional drugs: overview of the clinical data. Med Princ Pract. 2012;21(5):404–28.CrossRefPubMed
34.
go back to reference Ezuruike UF, Prieto JM. The use of plants in the traditional management of diabetes in Nigeria: pharmacological and toxicological considerations. J Ethnopharmacol. 2014;155(2):857–924.CrossRefPubMed Ezuruike UF, Prieto JM. The use of plants in the traditional management of diabetes in Nigeria: pharmacological and toxicological considerations. J Ethnopharmacol. 2014;155(2):857–924.CrossRefPubMed
35.
go back to reference Borokini TI, Ighere DA, Clement M, Ajiboye TO, Alowonle AA. Ethnobiological survey of traditional medicine practice for the treatment of piles and diabetes mellitus in Oyo State. J Med Plants Stud. 2013;1:30–40. Borokini TI, Ighere DA, Clement M, Ajiboye TO, Alowonle AA. Ethnobiological survey of traditional medicine practice for the treatment of piles and diabetes mellitus in Oyo State. J Med Plants Stud. 2013;1:30–40.
36.
go back to reference Arowosegbe S, Olanipekun MK, Kayode J. Ethnobotanical survey of medicinal plants used for the treatment of diabetes mellitus in Ekiti Souh Senatorial District, Nigeria. Eur J Bot Plant Sci Phytol. 2015;2(4):1–8. Arowosegbe S, Olanipekun MK, Kayode J. Ethnobotanical survey of medicinal plants used for the treatment of diabetes mellitus in Ekiti Souh Senatorial District, Nigeria. Eur J Bot Plant Sci Phytol. 2015;2(4):1–8.
37.
go back to reference Kadiri M, Ojewumi AW, Agboola DAAM. Research article ethnobotanical survey of plants used in the management of diabetes mellitus in Abeokuta, Nigeria. J drug Deliv Ther. 2015;5(3):13–23. Kadiri M, Ojewumi AW, Agboola DAAM. Research article ethnobotanical survey of plants used in the management of diabetes mellitus in Abeokuta, Nigeria. J drug Deliv Ther. 2015;5(3):13–23.
38.
go back to reference Ofuegbe SO, Adedapo AA. Ethnomedicinal survey of some plants used for the treatment of diabetes in Ibadan, Nigeria. Asian J Med Sci. 2015;6(5):36–40.CrossRef Ofuegbe SO, Adedapo AA. Ethnomedicinal survey of some plants used for the treatment of diabetes in Ibadan, Nigeria. Asian J Med Sci. 2015;6(5):36–40.CrossRef
40.
go back to reference Okolie UV, Okeke CE, Oli JM, Ehiemere IO. Hypoglycaemic indices of Vernonia amygdalina on postprandial blood glucose concentration of healthy humans. Afr J Biotechnol. 2008;7(24):4581–5. Okolie UV, Okeke CE, Oli JM, Ehiemere IO. Hypoglycaemic indices of Vernonia amygdalina on postprandial blood glucose concentration of healthy humans. Afr J Biotechnol. 2008;7(24):4581–5.
41.
go back to reference Oguanobi NI, Paschal Chijioke C, Ghasi S. Anti-diabetic effect of crude leaf extracts of ocimum gratissimum in neonatal streptozotocin-induced type-2 model diabetic rats. Int J Pharm Pharm Sci. 2012;4(Suppl 5):77–83. Oguanobi NI, Paschal Chijioke C, Ghasi S. Anti-diabetic effect of crude leaf extracts of ocimum gratissimum in neonatal streptozotocin-induced type-2 model diabetic rats. Int J Pharm Pharm Sci. 2012;4(Suppl 5):77–83.
42.
go back to reference Ezeigbo OR, Barrah CS, Ezeigbo IC. Phytochemical Analysis and antidiabetic effect of aqueous and ethanolic extracts of Moringa oleifera leaves in alloxan-induced diabetic wistar albino rats using insulin as reference drug. Int J Diabetes Res. 2016;5(3):48–53. Ezeigbo OR, Barrah CS, Ezeigbo IC. Phytochemical Analysis and antidiabetic effect of aqueous and ethanolic extracts of Moringa oleifera leaves in alloxan-induced diabetic wistar albino rats using insulin as reference drug. Int J Diabetes Res. 2016;5(3):48–53.
43.
go back to reference Hussain SS, Khalid HE, Ahmed SM, Technologies A. Anti-diabetic activity of the leaves of Moringa oleifera Lam. growing in Sudan on streptozotocin-induced diabetic rats. Br J Med Heal Res. 2016;3(4):48–57. Hussain SS, Khalid HE, Ahmed SM, Technologies A. Anti-diabetic activity of the leaves of Moringa oleifera Lam. growing in Sudan on streptozotocin-induced diabetic rats. Br J Med Heal Res. 2016;3(4):48–57.
44.
go back to reference Aguwa CN, Ukwe CV, Inya-Agha SI, Okonta JM. Antidiabetic effect of picralima nitida aqueous seed extract in experimental rabbit model. J Nat Remedies. 2001;1(2):135–9. Aguwa CN, Ukwe CV, Inya-Agha SI, Okonta JM. Antidiabetic effect of picralima nitida aqueous seed extract in experimental rabbit model. J Nat Remedies. 2001;1(2):135–9.
45.
go back to reference Suleiman KA. Attitudes and beliefs of consumers of herbal medicines in Riyadh, Saudi Arabia. J Community Med Health Educ. 2013;4(2):2–7.CrossRef Suleiman KA. Attitudes and beliefs of consumers of herbal medicines in Riyadh, Saudi Arabia. J Community Med Health Educ. 2013;4(2):2–7.CrossRef
46.
go back to reference Al-Rowais NA. Herbal medicine in the treatment of diabetes mellitus. Saudi Med J. 2002;23:1237–41. Al-Rowais NA. Herbal medicine in the treatment of diabetes mellitus. Saudi Med J. 2002;23:1237–41.
47.
go back to reference Wazaify M, Afifi FU, El-Khateeb M, Ajlouni K. Complementary and alternative medicine use among Jordanian patients with diabetes. Complement Ther Clin Pract. 2011;17(2):71–5.CrossRefPubMed Wazaify M, Afifi FU, El-Khateeb M, Ajlouni K. Complementary and alternative medicine use among Jordanian patients with diabetes. Complement Ther Clin Pract. 2011;17(2):71–5.CrossRefPubMed
48.
go back to reference Egede LE, Ye X, Zheng D, Silverstein MD. The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes. Diabetes Care. 2002;25(2):324–9.CrossRefPubMed Egede LE, Ye X, Zheng D, Silverstein MD. The prevalence and pattern of complementary and alternative medicine use in individuals with diabetes. Diabetes Care. 2002;25(2):324–9.CrossRefPubMed
49.
go back to reference Huri HZ, Lian GTP, Hussain S, Pendek S, Widodo RT. A survey amongst complementary and alternative medicine users with Type 2 diabetes. Int J Diabetes Metab. 2009;17:9–15. Huri HZ, Lian GTP, Hussain S, Pendek S, Widodo RT. A survey amongst complementary and alternative medicine users with Type 2 diabetes. Int J Diabetes Metab. 2009;17:9–15.
50.
go back to reference Arcury TA, Bell RA, Snively BM, Smith SL, Skelly AH, Wetmore LK, Quandt SA. Complementary and alternative medicine use as health self-management: rural older adults with diabetes. J Gerontol B Psychol Sci Soc Sci. 2006;61:S62–70.CrossRefPubMedPubMedCentral Arcury TA, Bell RA, Snively BM, Smith SL, Skelly AH, Wetmore LK, Quandt SA. Complementary and alternative medicine use as health self-management: rural older adults with diabetes. J Gerontol B Psychol Sci Soc Sci. 2006;61:S62–70.CrossRefPubMedPubMedCentral
Metadata
Title
Herbal medicine use among Type 2 diabetes mellitus patients in Nigeria: understanding the magnitude and predictors of use
Authors
Ogochukwu Ukamaka Amaeze
Roseline Iberi Aderemi-Williams
Modupeola Anuoluwapo Ayo-Vaughan
Deborah Aderoju Ogundemuren
Damilola Segun Ogunmola
Emmanuel Nwanolue Anyika
Publication date
01-06-2018
Publisher
Springer International Publishing
Published in
International Journal of Clinical Pharmacy / Issue 3/2018
Print ISSN: 2210-7703
Electronic ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-018-0648-2

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