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Published in: International Journal of Clinical Pharmacy 1/2018

01-02-2018 | Research Article

Drug-related problems identified during geriatric medication review in the community pharmacy

Authors: Mounir Rhalimi, Alain Rauss, Eric Housieaux

Published in: International Journal of Clinical Pharmacy | Issue 1/2018

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Abstract

Background In line with the changing role of community pharmacists, we describe here a standardised procedure for detecting DRPs in elderly patients for use in community pharmacies. Objectives The primary aim was to describe the number and type of DRPs identified by community pharmacists in elderly patients. Secondary aims were to determine the number and type of associated pharmacist interventions (PIs) that were transmitted to the prescribers, and to identify risk factors associated with the occurrence of a PI. Setting Community pharmacies. Methods In this prospective, multicentre study, pharmacists received patients aged 65 and over. During a 30-min interview with patients who agreed to participate, patient characteristics were recorded such as age, weight, height, frailty (using the Short Emergency Geriatric Assessment grid), estimated renal function and compliance with treatment assessed by the Girerd scale. Main outcome measure DRPs characteristics. Results A total of 892 patients agreed to participate in 55 pharmacies. Among them 334 DRPs were identified and were associated with 259 PIs. Eighty-nine PIs of 259 were sent to the prescribing physicians; 70 (78%) were implemented by the general practitioner. Factors associated with the occurrence of a DRP are compliance problems [odds ratio (OR) = 1.8, 95% confidence interval (CI) (1.26–2.58)], frailty [OR = 1.3, 95% CI (1.01–1.66)], number of prescribed drugs per day [OR = 1.46, 95% CI (1.02–2.07)] and GFR < 60 mL/min [OR = 1.49, 95% CI (1.01–2.2)]. Conclusion This is the first standardised pharmaceutical assessment dedicated to the elderly carried out by community pharmacists in France. If implemented, it could help to find drug-related problems, identify frail elderly patients and ultimately decrease their exposure to iatrogenic medication errors.
Literature
1.
go back to reference Kohn LT, Corrigan JM, Donaldson MS. To err is human: building a safer health system. Washington, DC: National Academy Press; 2000. Kohn LT, Corrigan JM, Donaldson MS. To err is human: building a safer health system. Washington, DC: National Academy Press; 2000.
2.
go back to reference Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004;329(7456):15–9.CrossRefPubMedPubMedCentral Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004;329(7456):15–9.CrossRefPubMedPubMedCentral
3.
go back to reference Krska J, Cromarty JA, Arris F, Jamieson D, Hansford D, Duffus PR, et al. Pharmacist-led medication review in patients over 65: a randomized, controlled trial in primary care. Age Ageing. 2001;30(3):205–11.CrossRefPubMed Krska J, Cromarty JA, Arris F, Jamieson D, Hansford D, Duffus PR, et al. Pharmacist-led medication review in patients over 65: a randomized, controlled trial in primary care. Age Ageing. 2001;30(3):205–11.CrossRefPubMed
4.
go back to reference Morice E, Gabriel-Bordenave C, Auclair V, Juste M, Roberge C. Évaluation de la pratique d’analyse d’ordonnance dans les hôpitaux français [Evaluation of prescription checking practices by French hospital Pharmacists]. Le Pharmacien Hospitalier et Clinicien. 2011;46(3):293–5.CrossRef Morice E, Gabriel-Bordenave C, Auclair V, Juste M, Roberge C. Évaluation de la pratique d’analyse d’ordonnance dans les hôpitaux français [Evaluation of prescription checking practices by French hospital Pharmacists]. Le Pharmacien Hospitalier et Clinicien. 2011;46(3):293–5.CrossRef
5.
go back to reference Martin SF, Van Mil JW, Da Costa FA. The organizational framework of community pharmacies in Europe. Int J Clin Pharm. 2015;37(5):896–905.CrossRef Martin SF, Van Mil JW, Da Costa FA. The organizational framework of community pharmacies in Europe. Int J Clin Pharm. 2015;37(5):896–905.CrossRef
6.
go back to reference Harris IM, Phillips B, Boyce E, Griesbach S, Hope C, Sanoski C, et al. Clinical pharmacy should adopt a consistent process of direct patient care. Pharmacotherapy. 2014;34(8):e133–48.CrossRefPubMed Harris IM, Phillips B, Boyce E, Griesbach S, Hope C, Sanoski C, et al. Clinical pharmacy should adopt a consistent process of direct patient care. Pharmacotherapy. 2014;34(8):e133–48.CrossRefPubMed
7.
go back to reference Bates DW, Spell N, Cullen DJ, Burdick E, Laird N, Petersen LA, et al. Adverse drug events prevention group. The costs of adverse drug events in hospitalized patients. JAMA. 1997;277(4):307–11.CrossRefPubMed Bates DW, Spell N, Cullen DJ, Burdick E, Laird N, Petersen LA, et al. Adverse drug events prevention group. The costs of adverse drug events in hospitalized patients. JAMA. 1997;277(4):307–11.CrossRefPubMed
8.
go back to reference Gallagher J, Byrne S, Woods N, Lynch D, McCarthy S. Cost-outcome description of clinical pharmacist interventions in a university teaching hospital. BMC Health Serv Res. 2014;14:177.CrossRefPubMedPubMedCentral Gallagher J, Byrne S, Woods N, Lynch D, McCarthy S. Cost-outcome description of clinical pharmacist interventions in a university teaching hospital. BMC Health Serv Res. 2014;14:177.CrossRefPubMedPubMedCentral
9.
go back to reference Dooley MJ, Allen KM, Doecke CJ, Galbraith KJ, Taylor GR, Bright J, et al. A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals. Br J Clin Pharmacol. 2004;57(4):513–21.CrossRefPubMedPubMedCentral Dooley MJ, Allen KM, Doecke CJ, Galbraith KJ, Taylor GR, Bright J, et al. A prospective multicentre study of pharmacist initiated changes to drug therapy and patient management in acute care government funded hospitals. Br J Clin Pharmacol. 2004;57(4):513–21.CrossRefPubMedPubMedCentral
12.
go back to reference Linjakumpu T, Hartikainen S, Klaukka T, Veijola J, Kivelä SL, Isoaho R. Use of medications and polypharmacy are increasing among the elderly. J Clin Epidemiol. 2002;55:809–17.CrossRefPubMed Linjakumpu T, Hartikainen S, Klaukka T, Veijola J, Kivelä SL, Isoaho R. Use of medications and polypharmacy are increasing among the elderly. J Clin Epidemiol. 2002;55:809–17.CrossRefPubMed
13.
go back to reference Chan DC, Chen JH, Kuo HK, We CJ, Lu IS, Chiu LS, et al. Drug-related problems (DRPs) identified from geriatric medication safety review clinics. Arch Gerontol Geriatr. 2012;54(1):168–74.CrossRefPubMed Chan DC, Chen JH, Kuo HK, We CJ, Lu IS, Chiu LS, et al. Drug-related problems (DRPs) identified from geriatric medication safety review clinics. Arch Gerontol Geriatr. 2012;54(1):168–74.CrossRefPubMed
14.
go back to reference Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics ans pharmacodynamics: basic principles and pratical applications. Br J Clin Pharmacol. 2004;57:6–14.CrossRefPubMedPubMedCentral Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics ans pharmacodynamics: basic principles and pratical applications. Br J Clin Pharmacol. 2004;57:6–14.CrossRefPubMedPubMedCentral
15.
go back to reference Charpiat B, Conort O, Juste M, Rose FX, Roubille R, Bedouch P, et al. The French Society of clinical pharmacy ACT-IP project: ten years onward, results and prospects. Le Pharmacien Hospitalier et Clinicien. 2015;50:15–24.CrossRef Charpiat B, Conort O, Juste M, Rose FX, Roubille R, Bedouch P, et al. The French Society of clinical pharmacy ACT-IP project: ten years onward, results and prospects. Le Pharmacien Hospitalier et Clinicien. 2015;50:15–24.CrossRef
16.
go back to reference Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (ScreeningTool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83.CrossRefPubMed Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (ScreeningTool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83.CrossRefPubMed
17.
go back to reference Oubaya N, Mahmoudi R, Jolly D, Zulfiqar AA, Quignard E, Cunin C, et al. Screening for frailty in elderly subjects living at home: validation of the modified Short Emergency Geriatric assessment (SEGAm) instrument. J Nutr Health Aging. 2014;18(8):757–64.CrossRefPubMed Oubaya N, Mahmoudi R, Jolly D, Zulfiqar AA, Quignard E, Cunin C, et al. Screening for frailty in elderly subjects living at home: validation of the modified Short Emergency Geriatric assessment (SEGAm) instrument. J Nutr Health Aging. 2014;18(8):757–64.CrossRefPubMed
18.
go back to reference Girerd X, Hanon O, Anagnostopoulos K, Ciupek C, Mourad JJ, Consoli S. Evaluation de l’observance du traitement anti-hypertenseur par un questionnaire: mise au point et utilisation dans un service specialisé [Assessment of antihypertensive compliance using a self-administered questionnaire: development and use in a hypertension clinic]. Presse Med. 2001;30:1044–8.PubMed Girerd X, Hanon O, Anagnostopoulos K, Ciupek C, Mourad JJ, Consoli S. Evaluation de l’observance du traitement anti-hypertenseur par un questionnaire: mise au point et utilisation dans un service specialisé [Assessment of antihypertensive compliance using a self-administered questionnaire: development and use in a hypertension clinic]. Presse Med. 2001;30:1044–8.PubMed
19.
go back to reference Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41.CrossRefPubMed Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41.CrossRefPubMed
20.
go back to reference Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Int Med. 1999;130(6):461–70.CrossRefPubMed Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Int Med. 1999;130(6):461–70.CrossRefPubMed
21.
go back to reference Allenet B, Bedouch P, Rose FX, Escofier L, Roubille R, Juste M, et al. Validation of an instrument for the documentation of clinical pharmacists interventions. Pharm World Sci. 2006;28:181–8.CrossRefPubMed Allenet B, Bedouch P, Rose FX, Escofier L, Roubille R, Juste M, et al. Validation of an instrument for the documentation of clinical pharmacists interventions. Pharm World Sci. 2006;28:181–8.CrossRefPubMed
22.
go back to reference Helou R. Should we continue to use the Cockcroft–Gault formula? Nephron Clin Pract. 2010;116:c172–85.CrossRefPubMed Helou R. Should we continue to use the Cockcroft–Gault formula? Nephron Clin Pract. 2010;116:c172–85.CrossRefPubMed
23.
go back to reference Bell JS, Blacker N, Leblanc VT, Alderman PC, Phillips A, Rowett D, et al. Prescribing for older people with chronic renal impairment. Aust Fam Phys. 2013;42(1–2):24–8. Bell JS, Blacker N, Leblanc VT, Alderman PC, Phillips A, Rowett D, et al. Prescribing for older people with chronic renal impairment. Aust Fam Phys. 2013;42(1–2):24–8.
24.
go back to reference Basger BJ, Moles RJ, Chen TF. Application of drug-related problem (DRP) classification systems: a review of the literature. Eur J Clin Pharmacol. 2014;70(7):799–815.CrossRefPubMed Basger BJ, Moles RJ, Chen TF. Application of drug-related problem (DRP) classification systems: a review of the literature. Eur J Clin Pharmacol. 2014;70(7):799–815.CrossRefPubMed
25.
go back to reference Krähenbühl JM, Kremer B, Guignard B, Bugnon O. Practical evaluation of the drug-related problem management process in Swiss community pharmacies. Pharm World Sci. 2008;30(6):777–86.CrossRefPubMed Krähenbühl JM, Kremer B, Guignard B, Bugnon O. Practical evaluation of the drug-related problem management process in Swiss community pharmacies. Pharm World Sci. 2008;30(6):777–86.CrossRefPubMed
26.
go back to reference Nicolas A, Eickhoff C, Griese N, Schulz M. Drug-related problems in prescribed medicines in Germany at the time of dispensing. Int J Clin Pharm. 2013;35(3):476–82.CrossRefPubMed Nicolas A, Eickhoff C, Griese N, Schulz M. Drug-related problems in prescribed medicines in Germany at the time of dispensing. Int J Clin Pharm. 2013;35(3):476–82.CrossRefPubMed
27.
go back to reference Bedouch P, Sylvoz N, Charpiat B, Juste M, Roubille R, Rose FX, et al. Trends in pharmacists’ medication order review in French hospitals from 2006 to 2009: analysis of pharmacists’ interventions from the Act-IP© website observatory. J Clin Pharm Ther. 2015;40(1):32–40.CrossRefPubMed Bedouch P, Sylvoz N, Charpiat B, Juste M, Roubille R, Rose FX, et al. Trends in pharmacists’ medication order review in French hospitals from 2006 to 2009: analysis of pharmacists’ interventions from the Act-IP© website observatory. J Clin Pharm Ther. 2015;40(1):32–40.CrossRefPubMed
28.
go back to reference Bardet JD, Vo T-H, Bedouch P, Allenet B. Physicians and community pharmacists collaboration in primary care: a review of specific models. Res Soc Adm Pharm. 2015;11(5):602–22.CrossRef Bardet JD, Vo T-H, Bedouch P, Allenet B. Physicians and community pharmacists collaboration in primary care: a review of specific models. Res Soc Adm Pharm. 2015;11(5):602–22.CrossRef
29.
go back to reference Tan E, Stewart K, Elliott R. Pharmacist services provided in general practice clinics: a systematic review and meta-analysis. Res Soc Adm Pharm. 2014;10(4):608–22.CrossRef Tan E, Stewart K, Elliott R. Pharmacist services provided in general practice clinics: a systematic review and meta-analysis. Res Soc Adm Pharm. 2014;10(4):608–22.CrossRef
30.
go back to reference Hirsch JD, Steers N, Adler DS. Primary care-based, pharmacist-physician collaborative medication-therapy management of hypertension: a randomized, pragmatic trial. Clin Ther. 2014;36(9):1244–54.CrossRefPubMedPubMedCentral Hirsch JD, Steers N, Adler DS. Primary care-based, pharmacist-physician collaborative medication-therapy management of hypertension: a randomized, pragmatic trial. Clin Ther. 2014;36(9):1244–54.CrossRefPubMedPubMedCentral
31.
go back to reference Taylor DG, Garfield S, Hawkins J, Newbould J, Rennie T. Greater expectations. Pharmacy based health care: the future for Europe? Policy Paper. 2007;5:1–19. Taylor DG, Garfield S, Hawkins J, Newbould J, Rennie T. Greater expectations. Pharmacy based health care: the future for Europe? Policy Paper. 2007;5:1–19.
Metadata
Title
Drug-related problems identified during geriatric medication review in the community pharmacy
Authors
Mounir Rhalimi
Alain Rauss
Eric Housieaux
Publication date
01-02-2018
Publisher
Springer International Publishing
Published in
International Journal of Clinical Pharmacy / Issue 1/2018
Print ISSN: 2210-7703
Electronic ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-017-0571-y

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