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Published in: International Journal of Clinical Pharmacy 3/2014

01-06-2014 | Research Article

Large scale implementation of clinical medication reviews in Dutch community pharmacies: drug-related problems and interventions

Authors: Thomas G. H. Kempen, Caroline H. P. A. van de Steeg-van Gompel, Petra Hoogland, Yuqian Liu, Marcel L. Bouvy

Published in: International Journal of Clinical Pharmacy | Issue 3/2014

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Abstract

Background

Research on the benefits of clinical medication reviews (CMRs) performed by pharmacists has been conducted mostly in controlled settings and has been widely published. Less is known of the effects after large scale implementation in community pharmacies. An online CMR tool enabled the systematic registration of drug-related problems (DRPs) and implemented interventions derived from CMRs in daily practice.

Objective

To describe the effects of CMRs on pharmacy practice after large-scale implementation in the Netherlands.

Setting

268 community pharmacies. Pharmacists were trained on CMRs with a patient centred approach.

Method

Retrospective analyses of DRPs, pharmacists’ proposals and implemented interventions recorded between January 1st and September 1st 2012.

Main outcome measure

Frequencies of DRPs, intervention proposals, implemented interventions, and drugs involved.

Results

4,579 CMRs were analysed. On average 2.9 (SD 2.1) DRPs per review were identified. 4,123 (31 %) of the DRPs led to medication changes. Stopping a drug (16 %) was more frequent than starting a drug (8.1 %). Drugs related to cardiovascular risk management, diabetes and osteoporosis were most frequently involved.

Conclusion

This study is the largest analysis of pharmacists-initiated CMRs in the Netherlands to date. The findings demonstrate the potential to reduce medication-related errors through pharmacist involvements in complex pharmacotherapy and the positive impact on the quality of drug therapy through making necessary medication changes. The data also support the need for large-scale implementation of pharmacists-initiated CMRs in the presence of proper training programmes.
Literature
3.
go back to reference Patterson S, Hughes C, Kerse N, Cardwell C, Bradley M. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2012;5:CD008165.PubMed Patterson S, Hughes C, Kerse N, Cardwell C, Bradley M. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2012;5:CD008165.PubMed
4.
go back to reference Task Force on Medicines Partnership and The National Collaborative Medicines Management Services Programme. Room for review. A guide to medication review: the agenda for patients, practitioners and managers. 1st ed. London: Medicines Partnership; 2002. ISBN 0-9544028-0-4. Task Force on Medicines Partnership and The National Collaborative Medicines Management Services Programme. Room for review. A guide to medication review: the agenda for patients, practitioners and managers. 1st ed. London: Medicines Partnership; 2002. ISBN 0-9544028-0-4.
5.
go back to reference Sorensen L, Stokes J, Purdie D, Woodward M, Elliott R, Roberts M. Medication reviews in the community: results of a randomized, controlled effectiveness trial. Br J Clin Pharmacol. 2004;58(6):648–64.PubMedCentralPubMedCrossRef Sorensen L, Stokes J, Purdie D, Woodward M, Elliott R, Roberts M. Medication reviews in the community: results of a randomized, controlled effectiveness trial. Br J Clin Pharmacol. 2004;58(6):648–64.PubMedCentralPubMedCrossRef
6.
go back to reference Zermansky AG, Petty DR, Raynor DK, Freemantle N, Vail A, Lowe CJ. Randomised controlled trial of clinical medication review by a pharmacist of elderly patients receiving repeat prescriptions in general practice. BMJ. 2001;323(7325):1340–3.PubMedCentralPubMedCrossRef Zermansky AG, Petty DR, Raynor DK, Freemantle N, Vail A, Lowe CJ. Randomised controlled trial of clinical medication review by a pharmacist of elderly patients receiving repeat prescriptions in general practice. BMJ. 2001;323(7325):1340–3.PubMedCentralPubMedCrossRef
7.
go back to reference Holland R, Lenaghan E, Harvey I, Smith R, Shepstone L, Lipp A, et al. Does home based medication review keep older people out of hospital? The HOMER randomised controlled trial. BMJ. 2005;330(7486):293.PubMedCentralPubMedCrossRef Holland R, Lenaghan E, Harvey I, Smith R, Shepstone L, Lipp A, et al. Does home based medication review keep older people out of hospital? The HOMER randomised controlled trial. BMJ. 2005;330(7486):293.PubMedCentralPubMedCrossRef
8.
go back to reference Geurts MME, Talsma J, Brouwers JRBJ, de Gier J. Medication review and reconciliation with cooperation between pharmacist and general practitioner and the benefit for the patient: a systematic review. Br J Clin Pharmacol. 2012;74(1):16–33.PubMedCentralPubMedCrossRef Geurts MME, Talsma J, Brouwers JRBJ, de Gier J. Medication review and reconciliation with cooperation between pharmacist and general practitioner and the benefit for the patient: a systematic review. Br J Clin Pharmacol. 2012;74(1):16–33.PubMedCentralPubMedCrossRef
9.
go back to reference Fiß T, Meinke-Franze C, van den Berg N, Hoffmann W. Effects of a three party healthcare network on the incidence levels of drug related problems. Int J Clin Pharm. 2013;35(5):763–71.PubMedCrossRef Fiß T, Meinke-Franze C, van den Berg N, Hoffmann W. Effects of a three party healthcare network on the incidence levels of drug related problems. Int J Clin Pharm. 2013;35(5):763–71.PubMedCrossRef
10.
go back to reference Milos V, Rekman E, Bondesson Å, Eriksson T, Jakobsson U, Westerlund T, et al. Improving the quality of pharmacotherapy in elderly primary care patients through medication reviews: a randomised controlled study. Drugs Aging. 2013;30(4):235–46.PubMedCrossRef Milos V, Rekman E, Bondesson Å, Eriksson T, Jakobsson U, Westerlund T, et al. Improving the quality of pharmacotherapy in elderly primary care patients through medication reviews: a randomised controlled study. Drugs Aging. 2013;30(4):235–46.PubMedCrossRef
12.
go back to reference Denneboom W, Dautzenberg MGH, Grol R, De Smet PAGM. Treatment reviews of older people on polypharmacy in primary care: cluster controlled trial comparing two approaches. Br J Gen Pract. 2007;57(542):723–31.PubMedCentralPubMed Denneboom W, Dautzenberg MGH, Grol R, De Smet PAGM. Treatment reviews of older people on polypharmacy in primary care: cluster controlled trial comparing two approaches. Br J Gen Pract. 2007;57(542):723–31.PubMedCentralPubMed
13.
go back to reference Leikola SNS, Virolainen J, Tuomainen L, Tuominen R, Airaksinen MSA. Comprehensive medication reviews for elderly patients: findings and recommendations to physicians. J Am Pharm Assoc. 2012;52(5):630–3.CrossRef Leikola SNS, Virolainen J, Tuomainen L, Tuominen R, Airaksinen MSA. Comprehensive medication reviews for elderly patients: findings and recommendations to physicians. J Am Pharm Assoc. 2012;52(5):630–3.CrossRef
14.
go back to reference Vinks THAM, Egberts TCG, de Lange T, de Koning FHP. Pharmacist-based medication review reduces potential drug-related problems in the elderly: the SMOG controlled trial. Drugs Aging. 2009;26(2):123–33.PubMedCrossRef Vinks THAM, Egberts TCG, de Lange T, de Koning FHP. Pharmacist-based medication review reduces potential drug-related problems in the elderly: the SMOG controlled trial. Drugs Aging. 2009;26(2):123–33.PubMedCrossRef
15.
go back to reference Brulhart M, Wermeille J. Multidisciplinary medication review: evaluation of a pharmaceutical care model for nursing homes. Int J Clin Pharm. 2011;33(3):549–57.PubMedCrossRef Brulhart M, Wermeille J. Multidisciplinary medication review: evaluation of a pharmaceutical care model for nursing homes. Int J Clin Pharm. 2011;33(3):549–57.PubMedCrossRef
16.
go back to reference Stafford A, Tenni P, Peterson G, Jackson S, Hejlesen A, Villesen C, et al. Drug-related problems identified in medication reviews by Australian pharmacists. Pharm World Sci. 2009;31(2):216–23.PubMedCrossRef Stafford A, Tenni P, Peterson G, Jackson S, Hejlesen A, Villesen C, et al. Drug-related problems identified in medication reviews by Australian pharmacists. Pharm World Sci. 2009;31(2):216–23.PubMedCrossRef
17.
go back to reference Shimp L, Kucukarslan S, Elder J, Remington T, Wells T, Choe H, et al. Employer-based patient-centered medication therapy management program: evidence and recommendations for future programs. J Am Pharm Assoc. 2012;52(6):768–76.CrossRef Shimp L, Kucukarslan S, Elder J, Remington T, Wells T, Choe H, et al. Employer-based patient-centered medication therapy management program: evidence and recommendations for future programs. J Am Pharm Assoc. 2012;52(6):768–76.CrossRef
18.
go back to reference Nishtala P, McLachlan A, Bell JS, Chen T. A retrospective study of drug-related problems in Australian aged care homes: medication reviews involving pharmacists and general practitioners. J Eval Clin Pract. 2011;17(1):97–103.PubMedCrossRef Nishtala P, McLachlan A, Bell JS, Chen T. A retrospective study of drug-related problems in Australian aged care homes: medication reviews involving pharmacists and general practitioners. J Eval Clin Pract. 2011;17(1):97–103.PubMedCrossRef
19.
go back to reference Freeman C, Cottrell WN, Kyle G, Williams I, Nissen L. An evaluation of medication review reports across different settings. Int J Clin Pharm. 2013;35(1):5–13.PubMedCrossRef Freeman C, Cottrell WN, Kyle G, Williams I, Nissen L. An evaluation of medication review reports across different settings. Int J Clin Pharm. 2013;35(1):5–13.PubMedCrossRef
20.
go back to reference Kwint HF, Faber A, Gussekloo J, Bouvy ML. The contribution of patient interviews to the identification of drug-related problems in home medication review. J Clin Pharm Ther. 2012;37(6):674–80.PubMedCrossRef Kwint HF, Faber A, Gussekloo J, Bouvy ML. The contribution of patient interviews to the identification of drug-related problems in home medication review. J Clin Pharm Ther. 2012;37(6):674–80.PubMedCrossRef
21.
go back to reference Stichting Farmaceutische Kengetallen [Foundation for Pharmaceutical Statistics]. Data en feiten 2013 [Data and facts 2013]. Den Haag: SFK; 2012. ISBN 978-90-817780-1-5. Stichting Farmaceutische Kengetallen [Foundation for Pharmaceutical Statistics]. Data en feiten 2013 [Data and facts 2013]. Den Haag: SFK; 2012. ISBN 978-90-817780-1-5.
22.
go back to reference Gezondheidsraad [Health Council of the Netherlands]. Evaluatie van de voedingsnormen voor vitamine D [Evaluation of the dietary reference values for vitamin D]. Den Haag: Gezondheidsraad; 2012. 150 p. Report No.: 2012/15. ISBN 978-90-5549-931-1. Gezondheidsraad [Health Council of the Netherlands]. Evaluatie van de voedingsnormen voor vitamine D [Evaluation of the dietary reference values for vitamin D]. Den Haag: Gezondheidsraad; 2012. 150 p. Report No.: 2012/15. ISBN 978-90-5549-931-1.
23.
go back to reference Lau HS, de Boer A, Beuning KS, Porsius A. Validation of pharmacy records in drug exposure assessment. J Clin Epidemiol. 1997;50(5):619–25.PubMedCrossRef Lau HS, de Boer A, Beuning KS, Porsius A. Validation of pharmacy records in drug exposure assessment. J Clin Epidemiol. 1997;50(5):619–25.PubMedCrossRef
Metadata
Title
Large scale implementation of clinical medication reviews in Dutch community pharmacies: drug-related problems and interventions
Authors
Thomas G. H. Kempen
Caroline H. P. A. van de Steeg-van Gompel
Petra Hoogland
Yuqian Liu
Marcel L. Bouvy
Publication date
01-06-2014
Publisher
Springer Netherlands
Published in
International Journal of Clinical Pharmacy / Issue 3/2014
Print ISSN: 2210-7703
Electronic ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-014-9947-4

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