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01-02-2016 | Clinical Study

Pseudoprogression in glioblastoma patients: the impact of extent of resection

Authors: Hun Ho Park, Tae Hoon Roh, Seok Gu Kang, Eui Hyun Kim, Chang-Ki Hong, Se Hoon Kim, Sung Soo Ahn, Seung Koo Lee, Hye Jin Choi, Jaeho Cho, Sun Ho Kim, Kyu-Sung Lee, Chang-Ok Suh, Jong Hee Chang

Published in: Journal of Neuro-Oncology | Issue 3/2016

Abstract

Pseudoprogression (psPD) is a radiation-induced toxicity that has substantial neurological consequence in glioblastoma (GBM) patients. MGMT promoter methylation has been shown to be an important prognostic factor of psPD, but the significance of extent of resection (EOR) remains unclear. We performed a retrospective analysis on newly diagnosed GBM patients with assessable MGMT promoter status who underwent the Stupp protocol. EOR was grouped into gross total resection (GTR), subtotal resection (STR), partial resection (PR) and stereotactic biopsy. Contrast enhancing lesion enlargement was classified as psPD or non-psPD. Among a total of 101 patients, GTR, STR, PR and stereotactic biopsy was performed in 57 (56.4 %), 34 (33.7 %), 9 (8.9 %) and 1 patient (1 %), respectively. Follow-up imaging at the end of Stupp protocol classified 45 patients (44.6 %) as psPD and 56 (55.4 %) as non-psPD. psPD was observed in 24 (61.5 %) of 39 patients with methylated MGMT promoter and 21 (33.9 %) of 62 patients with unmethylated MGMT promoter (p < 0.01). psPD was documented in 17 (29.8 %), 19 (55.9 %), 8 (88.9 %) and 1 (100 %) patient with GTR, STR, PR and stereotactic biopsy (p < 0.01), respectively. On multivariate analysis MGMT promoter status (OR 3.36, 95 % CI 1.36–8.34) and EOR (OR 4.12, 95 % CI 1.71–9.91) were independent predictors of psPD. A Cox proportional hazards model showed that MGMT status (HR 2.51, p < 0.01) and EOR (HR 2.99, p < 0.01) significantly influenced survival. MGMT status and EOR have a significant impact on psPD. GTR can reduce the side effects of psPD and prolong survival.

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Title: Pseudoprogression in glioblastoma patients: the impact of extent of resection
Authors: Hun Ho Park
Tae Hoon Roh
Seok Gu Kang
Eui Hyun Kim
Chang-Ki Hong
Se Hoon Kim
Sung Soo Ahn
Seung Koo Lee
Hye Jin Choi
Jaeho Cho
Sun Ho Kim
Kyu-Sung Lee
Chang-Ok Suh
Jong Hee Chang
Publication date: 01-02-2016
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2016
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-015-2001-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Pseudoprogression in glioblastoma patients: the impact of extent of resection

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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