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01-03-2007 | Clinical-Patient Studies

Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma

Authors: Marc C. Chamberlain, Michael J. Glantz, Lisa Chalmers, Alixis Van Horn, Andrew E. Sloan

Published in: Journal of Neuro-Oncology | Issue 1/2007

Abstract

Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this regimen, 7 patients (14%) manifested surgically confirmed early necrosis without evidence of recurrent tumor. This observation suggests that daily TMZ may represent a potent radiosensitizing regimen.

Stupp R, Dietrich P-Y, Ostermann Kraljevic S et al (2002) Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 20:1375–1382PubMedCrossRef

Stupp R, Mason WP, van den Bent M et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Eng J Med 352:987–996CrossRef

Glantz M, Chamberlain M, Liu Q, Litofsky NS, Recht LD (2003) Temozolomide as an alternative to irradiation for elderly patients with newly diagnosed malignant gliomas. Cancer 97:2262–2266PubMedCrossRef

Curran WJ Jr, Scott CB, Horton J et al (1993) Recursive partitioning analysis of prognostic factors in three radiation therapy oncology group malignant glioma trials. J Natl Cancer Inst 85:704–710PubMedCrossRef

DeAngelis LM (2001) Brain tumors. N Eng J Med 344:114–123CrossRef

Stewart LA (2002) Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual data from 12 randomized trials. Lancet 359:1011–1018PubMedCrossRef

de Wit MCY, de Bruin HG, Eijkenboom W, Sillevis-Smitt PAE, van den Bent MJ (2004) Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression. Neurology 63:535–537PubMed

Cross NE, Glantz MJ (2003) Neurologic complications of radiation therapy. In Wen PY, Glantz MJ (eds) Complications of Systemic Cancer. W.B. Saunders Co., Philadelphia, pp 249–277

Title: Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma
Authors: Marc C. Chamberlain
Michael J. Glantz
Lisa Chalmers
Alixis Van Horn
Andrew E. Sloan
Publication date: 01-03-2007
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Journal of Neuro-Oncology / Issue 1/2007
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-006-9241-y

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Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma

Abstract

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Abstract

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