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01-02-2021 | Folic Acid | Original Article

Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose

Authors: Michelle Lima Garcez, Ricardo Chiengo Sapalo Cassoma, Francielle Mina, Tatiani Bellettini-Santos, Aline Pereira da Luz, Gustavo Luis Schiavo, Eduarda Behenck Medeiros, Ana Carolina Brunatto Falchetti Campos, Sabrina da Silva, Lisienny Campoli Tono Rempel, Amanda Valnier Steckert, Tatiana Barichello, Josiane Budni

Published in: Metabolic Brain Disease | Issue 2/2021

Abstract

The present study aimed to evaluate the effect of folic acid treatment in an animal model of aging induced by D-galactose (D-gal). For this propose, adult male Wistar rats received D-gal intraperitoneally (100 mg/kg) and/or folic acid orally (5 mg/kg, 10 mg/kg or 50 mg/kg) for 8 weeks. D-gal caused habituation memory impairment, and folic acid (10 mg/kg and 50 mg/kg) reversed this effect. However, folic acid 50 mg/kg per se caused habituation memory impairment. D-gal increased the lipid peroxidation and oxidative damage to proteins in the prefrontal cortex and hippocampus from rats. Folic acid (5 mg/kg, 10 mg/kg, or 50 mg/kg) partially reversed the oxidative damage to lipids in the hippocampus, but not in the prefrontal cortex, and reversed protein oxidative damage in the prefrontal cortex and hippocampus. D-gal induced synaptophysin and BCL-2 decrease in the hippocampus and phosphorylated tau increase in the prefrontal cortex. Folic acid was able to reverse these D-gal-related alterations in the protein content. The present study shows folic acid supplementation as an alternative during the aging to prevent cognitive impairment and brain alterations that can cause neurodegenerative diseases. However, additional studies are necessary to elucidate the effect of folic acid in aging.

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Title: Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose
Authors: Michelle Lima Garcez
Ricardo Chiengo Sapalo Cassoma
Francielle Mina
Tatiani Bellettini-Santos
Aline Pereira da Luz
Gustavo Luis Schiavo
Eduarda Behenck Medeiros
Ana Carolina Brunatto Falchetti Campos
Sabrina da Silva
Lisienny Campoli Tono Rempel
Amanda Valnier Steckert
Tatiana Barichello
Josiane Budni
Publication date: 01-02-2021
Publisher: Springer US
Keywords: Folic Acid
Alzheimer's Disease
Alzheimer's Disease
Published in: Metabolic Brain Disease / Issue 2/2021
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-020-00647-7

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Folic acid prevents habituation memory impairment and oxidative stress in an aging model induced by D-galactose

Abstract

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Abstract

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