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01-04-2020 | Affective Disorder | Original Article

Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats

Authors: Yong He, Yue Wang, Zhonghao Wu, Tianlan Lan, Yu Tian, Xi Chen, Yan Li, Ruozhi Dang, Mengge Bai, Ke Cheng, Peng Xie

Published in: Metabolic Brain Disease | Issue 4/2020

Abstract

Major depressive disorder (MDD) is a serious mood disorder and leads to a high suicide rate as well as financial burden. The volume and function (the sensitivity and neurogenesis) of the olfactory bulb (OB) were reported to be altered among the MDD patients and rodent models of depression. In addition, the olfactory epithelium was newly reported to decrease its volume and function under chronic unpredictable mild stress (CUMS) treatment. However, the underlying molecular mechanism still remains unclear. Herein, we conducted the non-targeted metabolomics method based on gas chromatography-mass spectrometry (GC-MS) coupled with multivariate statistical analysis to characterize the differential metabolites in OB of CUMS rats. Our results showed that 19 metabolites were categorized into two perturbed pathways: purine metabolism and lipid metabolism, which were regarded as the vital pathways concerned with dysfunction of OB. These findings indicated that the turbulence of metabolic pathways may be partly responsible for the dysfunction of OB in MDD.

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Title: Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats
Authors: Yong He
Yue Wang
Zhonghao Wu
Tianlan Lan
Yu Tian
Xi Chen
Yan Li
Ruozhi Dang
Mengge Bai
Ke Cheng
Peng Xie
Publication date: 01-04-2020
Publisher: Springer US
Keywords: Affective Disorder
Affective Disorder
Published in: Metabolic Brain Disease / Issue 4/2020
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-020-00557-8

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive rats

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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