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01-02-2019 | Original Article

Excessive corticosterone induces excitotoxicity of hippocampal neurons and sensitivity of potassium channels via insulin-signaling pathway

Authors: Qingqing Xia, Hui Wang, Hongqiang Yin, Zhuo Yang

Published in: Metabolic Brain Disease | Issue 1/2019

Abstract

Corticosterone (CORT) is a kind of corticosteroid produced by cortex of adrenal glands. Hypothalamic–pituitary–adrenal (HPA) axis hyperfunction leads to excessive CORT, which is associated with depression. Few studies have investigated the role of CORT in voltage-gated ion channels and its upstream signaling pathway in central nervous system. In this study, we investigated the mechanism of excessive CORT resulting in brain impairment on voltage-gated ion channels, and its upstream signaling effectors in hippocampal CA1 neurons. The action potential (AP) and voltage-gated potassium currents were determined by using whole-cell patch-clamp. Insulin and CORT improved the neuronal excitability. Independent effects existed in transient potassium channel (I_A) and delay rectifier potassium channel (I_K). The inhibition of potassium currents, I_A in our experiment, could increase neuronal excitability. CORT led to the excitotoxicity of hippocampal neurons via phosphatidylinositol 3 kinase (PI3K)-mediated insulin-signaling pathway. Therefore, the stimulation of excessive CORT induces excitotoxicity of hippocampal neurons and sensitivity of potassium channels via PI3K-mediated insulin-signaling pathway, which indicates one possible way of depression treatment.

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Title: Excessive corticosterone induces excitotoxicity of hippocampal neurons and sensitivity of potassium channels via insulin-signaling pathway
Authors: Qingqing Xia
Hui Wang
Hongqiang Yin
Zhuo Yang
Publication date: 01-02-2019
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 1/2019
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-018-0326-z

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Excessive corticosterone induces excitotoxicity of hippocampal neurons and sensitivity of potassium channels via insulin-signaling pathway

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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