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01-10-2017 | ORIGINAL ARTICLE

Resveratrol Attenuates Aβ-Induced Early Hippocampal Neuron Excitability Impairment via Recovery of Function of Potassium Channels

Authors: Hongqiang Yin, Hui Wang, Hui Zhang, Na Gao, Tao Zhang, Zhuo Yang

Published in: Neurotoxicity Research | Issue 3/2017

Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disease. Amyloid-β (Aβ) is not only the morphological hallmark but also the initiator of the pathology process of AD. As a natural compound found in grapes, resveratrol shows a protective effect on the pathophysiology of AD, but the underlying mechanism is not very clear. This study was to investigate whether resveratrol could attenuate Aβ-induced early impairment in hippocampal neuron excitability and the underlying mechanism. The excitability and voltage-gated potassium currents were examined in rat hippocampal CA1 pyramidal neurons by using whole-cell patch-clamp technique. It was found that Aβ_25–35 increased the excitability of neurons. Resveratrol could reverse the Aβ_25–35-induced increase in the frequency of repetitive firing and the spike half-width of action potential (AP). Moreover, resveratrol can attenuate Aβ_25–35-induced decreases in transient potassium channel (I _A) and delay rectifier potassium channel (I _K(DR)) of neurons. It was also found that resveratrol could decline the increase of protein kinase A (PKA) and inhibit the activation of PI3K/Akt signaling pathway induced by Aβ_25–35. The results suggest that resveratrol alleviates Aβ_25–35-induced dysfunction in hippocampal CA1 pyramidal neurons via recovery of the function of I _A and I _K(DR) by inhibiting the increase of PKA and the activation of PI3K/Akt signaling pathway.

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Title: Resveratrol Attenuates Aβ-Induced Early Hippocampal Neuron Excitability Impairment via Recovery of Function of Potassium Channels
Authors: Hongqiang Yin
Hui Wang
Hui Zhang
Na Gao
Tao Zhang
Zhuo Yang
Publication date: 01-10-2017
Publisher: Springer US
Published in: Neurotoxicity Research / Issue 3/2017
Print ISSN: 1029-8428
Electronic ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-017-9726-9

At a glance: The STEP trials

Springer Medicine

Resveratrol Attenuates Aβ-Induced Early Hippocampal Neuron Excitability Impairment via Recovery of Function of Potassium Channels

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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