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Journal of Mammary Gland Biology and Neoplasia

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Open Access 01-06-2009

Macrophages in Breast Cancer: Do Involution Macrophages Account for the Poor Prognosis of Pregnancy-Associated Breast Cancer?

Authors: Jenean O’Brien, Pepper Schedin

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 2/2009

Abstract

Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention.

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Title: Macrophages in Breast Cancer: Do Involution Macrophages Account for the Poor Prognosis of Pregnancy-Associated Breast Cancer?
Authors: Jenean O’Brien
Pepper Schedin
Publication date: 01-06-2009
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 2/2009
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-009-9118-8

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Other articles of this Issue 2/2009

Differentiation of the Mammary Epithelial Cell during Involution: Implications for Breast Cancer

Mammary Involution and Breast Cancer Risk: Transgenic Models and Clinical Studies

Stat3 and the Inflammation/Acute Phase Response in Involution and Breast Cancer

The Role of Cathepsins in Involution and Breast Cancer

Pregnancy and Breast Cancer: when They Collide

A Mouse Mammary Gland Involution mRNA Signature Identifies Biological Pathways Potentially Associated with Breast Cancer Metastasis

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