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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-12-2008

IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons

Authors: S. John Weroha, Paul Haluska

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 4/2008

Abstract

The insulin-like growth factor pathway plays a major role in cancer cell proliferation, survival and resistance to anti-cancer therapies in many human malignancies, including breast cancer. As a key signaling component of IGF system, the IGF-1 receptor is the target of several investigational agents in clinical and pre-clinical development. This review will focus on the rationale for targeting the IGF-1 receptor and other components of the IGF-1 system. In addition, we will examine the role of IGF-1 signaling in resistance to clinically important breast cancer therapies, including cytotoxic chemotherapy, hormonal therapy and erbB targeted agents. We will also review the completed and ongoing clinical investigations with IGF-1 receptors inhibitors to date and the utility of these early data in designing future breast cancer studies with IGF-1 signaling inhibition strategies.

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Title: IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons
Authors: S. John Weroha
Paul Haluska
Publication date: 01-12-2008
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 4/2008
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-008-9104-6

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