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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-12-2008

Regulation of Breast Cancer Metastasis by IGF Signaling

Author: Deepali Sachdev

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 4/2008

Abstract

The insulin-like growth factors (IGFs) signaling via the type I insulin-like growth factor receptor (IGF-1R) regulate multiple aspects of malignancy. The importance of IGF-1R in regulating the malignant phenotype is currently being validated in numerous clinical trials for cancer including breast cancer. This review discusses the regulation of breast cancer metastasis by IGF-1R. IGF-1R stimulates invasion and survival in anchorage independent conditions. The regulation of metastasis independently of tumor growth by IGF-1R is also discussed. Finally, the impact of this on clinical trial design and outcomes, and the need for biomarkers, other than reduction in tumor size, are discussed in light of the fact that inhibition of metastasis is not measured in conventional clinical trial design.

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Title: Regulation of Breast Cancer Metastasis by IGF Signaling
Author: Deepali Sachdev
Publication date: 01-12-2008
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 4/2008
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-008-9105-5

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The IGF System in Mammary Development and Breast Cancer

IGF-I, GH, and Sex Steroid Effects in Normal Mammary Gland Development

Crosstalk Between IGF1R and Estrogen Receptor Signaling in Breast Cancer

IGF Binding Proteins (IGFBPs) and Regulation of Breast Cancer Biology

IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons

Cross-Talk Between the ErbB/HER Family and the Type I Insulin-Like Growth Factor Receptor Signaling Pathway in Breast Cancer

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