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Journal of Clinical Monitoring and Computing

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01-04-2019 | Letter to the Editor

Blood CO₂ exchange monitoring, Haldane effect and other calculations in sepsis and critical illness

Authors: Carlo Chiarla, Ivo Giovannini

Published in: Journal of Clinical Monitoring and Computing | Issue 2/2019

Excerpt

We would like to congratulate the Authors [1] for their interesting study and their effort to progressively determine the dominant factor (pH), among the many factors affecting P_cvaCO₂ and P_cvaCO₂/C_avO₂. Indeed, this is important also for clinical practice, because a busy ICU physician may be reluctant to deal with too many symbols, variables and equations, while simpler and well defined final messages are better accepted. …

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Saludes P, Proença L, Gruartmoner G, Enseñat L, Pérez-Madrigal A, Espinal C, Mesquida J. Central venous-to-arterial carbon dioxide difference and the effect of venous hyperoxia: a limiting factor, or an additional marker of severity in shock? J Clin Monit Comput. 2017;31:1203–11.CrossRefPubMed

Klocke RA. Carbon dioxide transport. In: Farhi LE, Tenney SM, editors. Handbook of physiology. The respiratory system, vol. 4. Bethesda: American Physiological Society; 1987. pp. 173–97

Teboul JL, Scheeren T. Understanding the Haldane effect. Intensive Care Med. 2017;43:91–3.CrossRefPubMed

Klocke RA. Mechanism and kinetics of the Haldane effect in human erythrocytes. J Appl Physiol. 1973;35:673–81.CrossRefPubMed

Giovannini I, Chiarla C, Boldrini G, Castagneto M. Calculation of venoarterial CO₂ concentration difference. J Appl Physiol. 1993;74:959–64.CrossRefPubMed

Douglas AR, Jones NL, Reed JW. Calculation of whole blood CO₂ content. J Appl Physiol. 1988;65:473–7.CrossRefPubMed

Lang W, Zander R. The accuracy of calculated base excess in blood. Clin Chem Lab Med. 2002;40:404–10.CrossRefPubMed

Singer RB, Hastings AB. An improved clinical method for the estimation of disturbances of the acid-base balance of human blood. Medicine (Baltimore) 1948;27:223–42.CrossRef

Title: Blood CO2 exchange monitoring, Haldane effect and other calculations in sepsis and critical illness
Authors: Carlo Chiarla
Ivo Giovannini
Publication date: 01-04-2019
Publisher: Springer Netherlands
Published in: Journal of Clinical Monitoring and Computing / Issue 2/2019
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-018-0160-1

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Blood CO₂ exchange monitoring, Haldane effect and other calculations in sepsis and critical illness

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