Top

Journal of Clinical Immunology

Published in:

01-02-2022 | Immunodeficiency | Letter to Editor

Dexamethasone Treatment for COVID-19-Related Lung Injury in an Adult with WHIM Syndrome

Authors: Daigo Akahane, Shunsuke Otsuki, Daisuke Hasegwa, Hidehiro Watanabe, Akihiko Gotoh

Published in: Journal of Clinical Immunology | Issue 2/2022

Excerpt

To the editor, …

Available only for authorised users

Hernandez PA, Gorlin RJ, Lukens JN, Taniuchi S, Bohinjec J, Francois F, et al. Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Nat Genet. 2003;34:70–4. https://doi.org/10.1038/ng1149.CrossRefPubMed

Heusinkveld LE, Majumdar S, Gao J-L, McDermott DH, Murphy PM. WHIM syndrome: from pathogenesis towards personalized medicine and cure. J Clin Immunol. 2019;39(6):532–56. https://doi.org/10.1007/s10875-019-00665-w.CrossRefPubMedPubMedCentral

Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, et al. Dexamethasone in hospitalized patients with COVID-19. N Engl J Med. 2021;384:693–704. https://doi.org/10.1056/NEJMoa2021436.CrossRefPubMed

Ricci E, Ronchetti S, Pericolini E, Gabrielli E, Cari L, Gentili M, et al. Role of the glucocorticoid-induced leucine zipper gene in dexamethasone-induced inhibition of mouse neutrophil migration via control of annexin A1 expression. FASEB J. 2017;31:3054–65. https://doi.org/10.1096/fj.201601315R.CrossRefPubMed

Cevik M, Tate M, Lloyd O, Maraolo AE, Schafers J, Ho A. SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis. Lancet Microbe. 2021;2(1):e13–22. https://doi.org/10.1016/S2666-5247(20)30172-5.CrossRefPubMed

Xu J, Mora A, Shim H, Stecenko A, Brigham KL, Rojas M, et al. Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis. Am J Respir Cell Mol Biol. 2007;37:291–9. https://doi.org/10.1165/rcmb.2006-0187OC.CrossRefPubMedPubMedCentral

Ghosh MC, Baatar D, Collins G, Carter A, Indig F, Biragyn A, et al. Dexamethasone augments CXCR4-mediated signaling in resting human T cells via the activation of the Src kinase Lck. Blood. 2009;113:575–84. https://doi.org/10.1182/blood-2008-04-151803.CrossRefPubMedPubMedCentral

Title: Dexamethasone Treatment for COVID-19-Related Lung Injury in an Adult with WHIM Syndrome
Authors: Daigo Akahane
Shunsuke Otsuki
Daisuke Hasegwa
Hidehiro Watanabe
Akihiko Gotoh
Publication date: 01-02-2022
Publisher: Springer US
Keywords: Immunodeficiency
SARS-CoV-2
Neutropenia
COVID-19
Dexamethasone
Published in: Journal of Clinical Immunology / Issue 2/2022
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-021-01185-2

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Dexamethasone Treatment for COVID-19-Related Lung Injury in an Adult with WHIM Syndrome

Excerpt

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 2/2022

Neonatal Manifestations of Chronic Granulomatous Disease: MAS/HLH and Necrotizing Pneumonia as Unusual Phenotypes and Review of the Literature

A Nationwide Study of GATA2 Deficiency in Norway—the Majority of Patients Have Undergone Allo-HSCT

Accelerated Maturation, Exhaustion, and Senescence of T cells in 22q11.2 Deletion Syndrome

CARD9 Expression Pattern, Gene Dosage, and Immunodeficiency Phenotype Revisited

Correction to: Robust Virus‐Specific Adaptive Immunity in COVID‐19 Patients with SARS‐CoV‐2 Δ382 Variant Infection

Prevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page