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Open Access 01-02-2021 | Primary Immunodeficiency | Original Article

Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency

Authors: Samaneh Delavari, Hassan Abolhassani, Farhad Abolnezhadian, Fateme Babaha, Sara Iranparast, Hamid Ahanchian, Nasrin Moazzen, Mohammad Nabavi, Saba Arshi, Morteza Fallahpour, Mohammad Hassan Bemanian, Sima Shokri, Tooba Momen, Mahnaz Sadeghi-Shabestari, Rasol Molatefi, Afshin Shirkani, Ahmad Vosughimotlagh, Molood Safarirad, Meisam Sharifzadeh, Salar Pashangzadeh, Fereshte Salami, Paniz Shirmast, Arezou Rezaei, Tannaz Moeini Shad, Minoo Mohraz, Nima Rezaei, Lennart Hammarström, Reza Yazdani, Asghar Aghamohamamdi

Published in: Journal of Clinical Immunology | Issue 2/2021

Abstract

Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents.

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Title: Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency
Authors: Samaneh Delavari
Hassan Abolhassani
Farhad Abolnezhadian
Fateme Babaha
Sara Iranparast
Hamid Ahanchian
Nasrin Moazzen
Mohammad Nabavi
Saba Arshi
Morteza Fallahpour
Mohammad Hassan Bemanian
Sima Shokri
Tooba Momen
Mahnaz Sadeghi-Shabestari
Rasol Molatefi
Afshin Shirkani
Ahmad Vosughimotlagh
Molood Safarirad
Meisam Sharifzadeh
Salar Pashangzadeh
Fereshte Salami
Paniz Shirmast
Arezou Rezaei
Tannaz Moeini Shad
Minoo Mohraz
Nima Rezaei
Lennart Hammarström
Reza Yazdani
Asghar Aghamohamamdi
Publication date: 01-02-2021
Publisher: Springer US
Keywords: Primary Immunodeficiency
Azithromycin
Immunodeficiency
SARS-CoV-2
COVID-19
Published in: Journal of Clinical Immunology / Issue 2/2021
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-020-00928-x

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