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Published in:

01-04-2019 | Cytokines | CME Review

CAPS and NLRP3

Authors: Laela M. Booshehri, Hal M. Hoffman

Published in: Journal of Clinical Immunology | Issue 3/2019

Abstract

Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 in CAPS patients lead to activation of the cryopyrin inflammasome, resulting in the inappropriate release of inflammatory cytokines including IL-1β and CAPS-related inflammatory symptoms. Several mechanisms have been identified that are important for the normal regulation of the cryopyrin inflammasome in order to prevent uncontrolled inflammation. Investigators have taken advantage of some of these pathways to develop and apply novel targeted therapies, which have resulted in improved quality of life for patients with this orphan disease.

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Title: CAPS and NLRP3
Authors: Laela M. Booshehri
Hal M. Hoffman
Publication date: 01-04-2019
Publisher: Springer US
Keyword: Cytokines
Published in: Journal of Clinical Immunology / Issue 3/2019
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-019-00638-z

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CAPS and NLRP3

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