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01-07-2018 | How I Manage

The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies

Authors: Dror S. Shouval, Matthew Kowalik, Scott B. Snapper

Published in: Journal of Clinical Immunology | Issue 5/2018

Abstract

The gastrointestinal tract is heavily populated with innate and adaptive immune cells that have an active role in preservation of mucosal homeostasis and prevention of inflammation. Inflammatory bowel diseases are thought to result from dysregulated immune function that is influenced by genetic background, environmental triggers, and microbiome changes. While most inflammatory bowel disease patients present in adolescent years or adulthood, in a minority of cases, the disease develops early in life, and in some of these young patients, a monogenic disease causing intestinal inflammation can be identified. Many of these conditions result from mutations in immune-mediated genes and can present with or without concomitant recurrent infections. In this review, we will discuss the treatment of patients with selected primary immunodeficiencies and inflammatory bowel diseases. We will focus on five conditions resulting from mutations in IL10/IL10 receptor, NADPH oxidase complex, XIAP, LRBA, and CTLA-4.

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Title: The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies
Authors: Dror S. Shouval
Matthew Kowalik
Scott B. Snapper
Publication date: 01-07-2018
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 5/2018
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-018-0524-9

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The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies

Abstract

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Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

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Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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