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Journal of Clinical Immunology
Published in: Journal of Clinical Immunology 1/2013

01-01-2013

The Immunologic Functions of the Neonatal Fc Receptor for IgG

Authors: Timo Rath, Timothy T. Kuo, Kristi Baker, Shuo-Wang Qiao, Kanna Kobayashi, Masaru Yoshida, Derry Roopenian, Edda Fiebiger, Wayne I. Lencer, Richard S. Blumberg

Published in: Journal of Clinical Immunology | Special Issue 1/2013

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Abstract

Careful regulation of the body’s immunoglobulin G (IgG) and albumin concentrations is necessitated by the importance of their respective functions. As such, the neonatal Fc receptor (FcRn), as a single receptor, is capable of regulating both of these molecules and has become an important focus of investigation. In addition to these essential protection functions, FcRn possesses a number of other functions that are equally as critical and are increasingly coming to attention. During the very first stages of life, FcRn mediates the passive transfer of IgG from mother to offspring both before and after birth. In the adult, FcRn regulates the persistence of both IgG and albumin in the serum as well as the movement of IgG, and any bound cargo, between different compartments of the body via transcytosis across polarized cells. FcRn is also expressed by hematopoietic cells; consistent with this, FcRn regulates MHC class II presentation and MHC class I cross-presentation by dendritic cells. As such, FcRn plays an important role in immune surveillance throughout adult life. The increasing appreciation for FcRn in both homeostatic and pathological conditions is generating an intense interest in the potential for therapeutic modulation of FcRn binding to IgG and albumin.
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Metadata
Title
The Immunologic Functions of the Neonatal Fc Receptor for IgG
Authors
Timo Rath
Timothy T. Kuo
Kristi Baker
Shuo-Wang Qiao
Kanna Kobayashi
Masaru Yoshida
Derry Roopenian
Edda Fiebiger
Wayne I. Lencer
Richard S. Blumberg
Publication date
01-01-2013
Publisher
Springer US
Published in
Journal of Clinical Immunology / Issue Special Issue 1/2013
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI
https://doi.org/10.1007/s10875-012-9768-y

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